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    A comparison of adductor canal block before and after thigh tourniquet during knee arthroscopy: A randomized, blinded study
    (Korean Society of Anesthesiologists, 2021) Ekinci, Mürsel; Çiftçi, Bahadır; Demiraran, Yavuz; Çelik, Erkan Cem; Yayık, Murat; Ömür, Burak; Kuyucu, Ersin; Atalay, Yunus Oktay
    Background: Adductor canal block (ACB) provides effective analgesia management after arthroscopic knee surgery. However, there is insufficient data about performing ACB before or after inflation of a thigh tourniquet. We aimed to investigate the efficacy of ACB when it is performed before and after thigh tourniquet and evaluate motor weakness. Methods: ACB was performed before the tourniquet inflation in the PreT group, it was performed after the inflation of the tourniquet in the PostT group. In the PO group, ACB was performed at the end of surgery after disinflation of the tourniquet. Results: There were no statistical differences between the groups in terms of demographic data. Opioid consumption showed no statistically significant differences (for total consumption; p = 0.5). The amount of rescue analgesia administered and patient satisfaction were also not significantly different between groups. There was no significant difference in terms of static and dynamic VAS scores between groups (for 24 hours; p = 0.3, p = 0.2 respectively). The incidence of motor block was higher in the PreT group (eight patients) than in the PostT group (no patients) and in the PO group (only one patient) (p = 0.005). Conclusions: Using a tourniquet before or after ACB may not result in any differences in terms of analgesia; however, applying a tourniquet immediately after ACB may lead to muscle weakness.
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    A comparison the effectiveness of wholebody vibration, progressive resistive exercise and home-based exercise in patients with knee osteoarthritis
    (BMJ Publishing Group, 2017) Pekesen Kurtça, Mine; Baş Aslan, Ümmühan; Kuyucu, Ersin
    [Abstract Not Available]
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    A suture technique for easier reduction and repair of bucket-handle meniscal tears while using the all-inside devices
    (Edp Sciences S A, 2016) Çetinkaya, Engin; Kuyucu, Ersin; Gül, Murat; Lapçin, Osman; Albayrak, Kutalmış; Gürsu, Sarper
    Arthroscopic repair of bucket-handle meniscal tears is difficult due to their complex pathology. Many meniscal repair techniques such as all-inside, inside-out, and outside-in have been described for the treatment of these tears. Loss of reduction is a likely complication with the use of new-generation, all-inside suture instruments, as the tip of the needle is extracted following advancement of the first implant behind the capsule. The complication may be encountered quite often and renders the use of the meniscus repair instrument unusable and causes an irreparable iatrogenic injury in the meniscus. The application of a simpler and more efficient technique is necessary until surgical experience is gained. The aim of this study was to define a new, simpler, and more efficient combination of suturing method in the treatment of bucket-handle meniscal repairs and minimize the rate of complications which may be caused by this technique.
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    Adverse effects of zoledronic acid infusion in patients treated for postmenopausal osteoporosis
    (2017) Kuyucu, Ersin
    Objective: Renal toxicity and hypocalcemia are two commonest adverse effects of zoledronic acid reported in cancer patients with bone metastasis. Similar data are lacking in postmenopausal women with osteoporosis treated with zoledronic acid infusion. We aimed to evaluate the effects of annual treatment of postmenopausal osteoporotic women with intravenous infusion of zoledronic acid on their renal and hepatic functions. The effects of the drug on the biochemical parameters of the patients were also assessed.Methods: We reviewed the electronic medical records (EMRs) of postmenopausal women with osteoporosis treated with 5 mg of zoledronic acid once in a year. Changes in the serum levels of calcium, phosphorus, alkaline phosphatase, creatinine, blood urea nitrogen (BUN) as well as alanine and aspartate transaminases were determined after infusing zoledronic acid relative to the base line results. Information about the documented adverse effects of zoledronic acid were extracted from the EMRs. Results: All the biochemical parameters, except calcium, demonstrated no statistically significant changes in their serum levels when the results, before and after treatment with zoledronic acid, were compared. The serum Ca level slightly and significantly decreased from 9.6±0.6 mg/dl (before treatment) to 9.4±0.9 mg/dl (after treatment) (p=0.018). A few but important adverse effects associated with zoledronic acid infusion in the patients were influenzalike symptoms (6), myalgia (4), arthralgia (4), headache (4), and pyrexia (3). Conclusions: The once in a year use of zoledronic acid infusion for osteoporosis in postmenopausal women was not associated with a statistically significant renal and hepatic adverse effects. Among the biochemical parameters evaluated, only serum calcium level decreased slightly and statistically significantly after using zoledronic acid infusion, despite prophylactic calcium use before treatment.
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    Application of hybrid external fixation by the “joystick method” in bicondylar tibial plateau fractures: Technical note
    (2018) Kuyucu, Ersin; Kara, Adnan; Say, Ferhat; Erdil, Mehmet; Bülbül, Murat; Gülenç, Barış
    BACKGROUND: This study aimed to present clinical outcomes in patients with tibial plateau fractures who were treated with hybrid external fixators and describe the details of our technique. Schanz screws were synchronously applied and used as a joystick for fracture reduction. METHODS: The study population included 72 patients with bicondylar tibial plateau fractures classified as type 41-C2 according to the AO classification. Joint reduction was maintained using Schanz screws transmitted through tibial condyles as a joystick under fluoroscopy. The patients then underwent surgery with these Schanz screws and a hybrid external fixation system. RESULTS: The median age of the patients was 39 (21–67) years, and the median follow-up time was 21 (12–35) months. The mean knee flexion and extension were 105° (80°–125°) and 0° (?5°–7°), respectively. The mean varus laxity and valgus laxity were 4.30° (2°–7°) and 3.10° (2°–5°), respectively. Four patients had leg shortness of 0.4–1.1 cm. The external fixators were removed between 8 and 16 weeks (mean = 11 weeks) postoperatively. The KSS scores at the end of 1 year were “excellent” for 48 patients, “good” for 19 patients, and “inadequate” for 5 patients. CONCLUSION: With the synchronous application of the two Schanz screws of 6.5-mm thickness and the two-drill technique under fluoroscopic guidance, we obtained stable reductions over a short period. No patient experienced major complications, and this enabled early weight bearing and a return to daily living activities.
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    Arthroscopic excision of tendinous giant cell tumors causing locking in the knee joint
    (Galen S.R.O., 2018) Gülenç, Barış; Kuyucu, Ersin; Yalçın, Sercan; Erdoğan Çakır, Aslı; Bülbül, Ahmet Murat
    PURPOSE OF THE STUDY Non-osseous giant cell tumors are locally aggressive tumors arising around joints. They are commonly located around synovial joints such as wrist and knee and occasionally cause mechanical symptoms. MATERIAL AND METHODS This retrospective case series includes 7 patients operated due to intraarticular lesion. The mean age of the patients was 28.7 (range 22-37) years. Mean follow-up period was 12 months. RESULTS All patients underwent arthroscopic debridement. They were followed monthly with clinical examination and magnetic resonance imaging (MRI) was obtained at third month for all patients. Patients were contacted through phone call and evaluated with the WOMAC score retrospectively. No recurrence was detected in any patient. CONCLUSIONS Arthroscopic debridement is a safe surgical technique that may replace open surgery in the treatment of intraarticular tendinous giant cell tumors.
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    Arthroscopic treatment of focal osteochondral lesions of the first metatarsophalangeal joint
    (BioMed Central Ltd., 2017) Kuyucu, Ersin; Mutlu, Harun; Mutlu, Serhat; Gülenç, Barış; Erdil, Mehmet
    Background: Although arthroscopic surgical treatment of the first metatarsophalangeal (MTP) joint involves painful sesamoid excision, synovectomy, debridement, and partial cheilectomy, no gold standard treatment technique has been defined in the literature for hallux rigidus and focal osteochondral lesions. This study aimed to assess the arthroscopic treatment for early-grade focal osteochondral lesions of the first MTP joint and to determine the impact of arthroscopic microhole drill surgery on foot function and activities of daily living in a group of patients who failed conservative treatment. Methods: This prospective study included 14 patients with hallux rigidus and focal osteochondral lesions of the first MTP joint who underwent surgery in 2014 and were followed on a regular basis thereafter. Results: The patients had mean preoperative VPS (visual pain scale) and AOFAS (American Orthopedic Foot and Ankle Society)-Hallux scores of 8.14 ± 0.86 SD and 48.64 ± 4.27, respectively; the corresponding postoperative values of both scores were 1.86 ± 0.66 SD and 87.00 ± 3.70, respectively. Both VPS and AOFAS-Hallux scores changed significantly. Discussion: In this prospective study, we explored the impact of arthroscopic microhole drill surgery on foot function and activities of daily living in patients with focal osteochondral lesions of the first MTP joint. Our results showed significant improvements in VPS and AOFAS scores with this treatment. Conclusions: An arthroscopic microhole drill technique can be used with impressive functional scores and without any complications in patients who failed conservative therapy for hallux rigidus with focal chondral injury.
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    Arthroscopic treatment of focal osteochondral lesions of the first metatarsophalangeal joint
    (BioMed Central Ltd., 2017) Kuyucu, Ersin; Mutlu, Harun; Mutlu, Serhat; Gülenç, Barış; Erdil, Mehmet
    Background: Although arthroscopic surgical treatment of the first metatarsophalangeal (MTP) joint involves painful sesamoid excision, synovectomy, debridement, and partial cheilectomy, no gold standard treatment technique has been defined in the literature for hallux rigidus and focal osteochondral lesions. This study aimed to assess the arthroscopic treatment for early grade focal osteochondral lesions of the first MTP joint and to determine the impact of arthroscopic microhole drill surgery on foot function and activities of daily living in a group of patients who failed conservative treatment.Methods: This prospective study included 14 patients with hallux rigidus and focal osteochondral lesions of the first MTP joint who underwent surgery in 2014 and were followed on a regular basis thereafter.Results: The patients had mean preoperative VPS (visual pain score) and AOFAS (American Orthopedic Foot and ankle Society)-Hallux scores of 8.14 +/- 0.86 SD and 48.64 +/- 4.27, respectively; the corresponding postoperative values of both scores were 1.86 +/- 0.66 SD and 87.00 +/- 3.70. Both VPS and AOFAS-Hallux scores changed significantly.Discussion: In this prospective study, we explored the impact of arthroscopic microhole drill surgery on foot function and activities of daily living in patients with focal osteochondral lesions of the first MTP joint. Our results showed significant improvements in VPS and AOFAS scores with this treatment.Conclusions: An arthroscopic microhole drill technique can be used with impressive functional scores and without any complications in patients who failed conservative therapy for hallux rigidus with focal chondral injury.
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    Arthroscopic treatment of focal osteochondral lesions of the first metatarsophalangeal joint (vol 12, 68, 2017)
    (BMC, 2019) Kuyucu, Ersin; Mutlu, Harun; Mutlu, Serhat; Gülenç, Barış; Erdil, Mehmet
    This article [2] was published twice [1] due to a production error. The original article [1] should be considered the version of record and used for citation purposes. The publisher apologizes to the authors and readers for the error and any inconvenience caused.
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    Assessment of the kinesiotherapy's efficacy in male athletes with calcaneal apophysitis
    (BMC, 2017) Kuyucu, Ersin; Gülenç, Barış; Biçer, Hüseyin; Erdil, Mehmet
    Background: The aim of the present study was to assess the efficacy of kinesiotherapy used for treating various disorders in athletes on pain and pedal functions in patients with calcaneal apophysitis. Methods: This prospective randomized controlled study included 22 patients with calcaneal apophysitis aged 8 to 16 years presenting with heel pain among junior athletes of a professional football club. The patients were randomly grouped into two groups, with one group receiving sham tape only and the other kinesio tape. American Orthopedic Foot & Ankle Society (AOFAS) and visual analog scale (VAS) scores were recorded before and after the treatment. Results: The preoperative VAS score of the kinesio tape was 7, and AOFAS score was 62.4; the corresponding figures of the sham group were 6.81 and 70.5, respectively. The kinesio-tape group had a better AOFAS scores at 1st and 3rd month (p < 0.05). Posttreatment AOFAS score was 99.7 +/- 0.9 for the kinesio-tape group and 97.4 +/- 3.9 for the sham-tape group. Posttreatment VAS score was 0.1 +/- 0.3 for the kinesio-tape group and 0.4 +/- 0.5 for the sham-tape group (p > 0.05). Discussion: Conservative treatment modalities are preferentially used for its treatment. Kinesiotherapy is one of the treatment methods for the apophysitis. In the literature, our study is the first prospective randomized trial on the efficacy of kinesio taping in calcaneal apophysitis. Conclusions: Although kinesio taping can be effectively used for the restoration of ankle functions of athletes with calcaneal apophysitis, its role in pain is limited. Since it lacks serious side effects, it can be used in combination with or as an alternative to pharmacological treatment in this patient group.
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    Association of real-time sonoelastography findings with clinical parameters in lateral epicondylitis
    (Springer Heidelberg, 2016) Koçyiğit, Figen; Kuyucu, Ersin; Koçyiğit, Ali; Herek Tuncer, Duygu; Şavkın, Raziye; Aslan Baş, Ümmühan; Karabulut, Nevzat
    The objective of this study was to investigate the role of real-time sonoelastography (RTSE) in patients with lateral epicondylitis (LE) and whether it is associated with clinical parameters. Seventeen patients with unilateral LE were enrolled in the study. The healthy elbows of the participants constituted the control group. Using B-mode ultrasound, color Doppler ultrasound, and RTSE, we prospectively examined 34 common extensor tendon elbows of 17 patients. Both color scales and strain ratio were used for evaluating RTSE images. Two radiologists evaluated the RTSE images separately. Elbow pain was scored on a 100-mm visual analog scale (VAS). Symptom duration and the presence of nocturnal pain were questioned. Quick disabilities of arm shoulder and hand (DASH) Questionnaire was applied to assess the pain, function, and disability. Nottingham health profile (NHP) was used to determine and quantify perceived health problems. Both color scales and strain ratios of the affected tendon portions were significantly different from that of healthy tendons (p < 0.001). There was no significant association between NHP, VAS, Quick DASH scores, and color scales and strain ratio. Strain ratio of the medial portion of the affected tendon was significantly correlated with symptom duration (rho = -0.61 p = 0.010) and nocturnal pain (rho = 0.522 p = 0.031). Interobserver agreement was substantial for color scales (kappa = 0.74, p = 0.001) and strain ratio (ICC = 0.61, p = 0.031). RTSE may facilitate differentiation between healthy and affected elbows as a feasible and practical supplementary method with substantial interobserver agreement. RTSE was superior to B-mode ultrasound and color Doppler ultrasound in discriminating tendons with LE. Strain ratio of the medial portion of the tendon is associated moderately with nocturnal pain and symptom duration. No other associations were present between RTSE findings and clinical or functional parameters.
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    Can intra-articular 1 alpha, 25-dihydroxyvitamin D3 administration be therapeutical in joint cartilage damage?
    (Galen s.r.o., 2020) Kuyucu, Ersin; Çabuk, Hüseyin; Güler, Yasin; Kuşku Çabuk, Fatmagül; Kılıç, Erdinç; Bülbül, Murat
    INTRODUCTION Vitamin D-deficiency is known to cause nerve conduction impairments, cancer and chronic diseases, as well as the pathogenesis of osteoarthritis. Our goal with this study is to evaluate the cartilage healing by applying intraarticular 1 alpha, 25 (OH) 2D3 at different doses in rats with normal vitamin D levels and metabolism, which we made focal chondral damage model in the knee joint. MATERIAL AND METHODS 35 male Sprague-Dawley rats aged 20-24 weeks were used in our study. Both knees of rats were cartilage defected surgically on day 0. Joint injections performed at 06:00 am on 0th and 2nd days and after second injection others performed on days 9-16 and 23 following a weekly period. RESULTS In the fourth week, hematoxylin eosin staining measurements showed statistically significant difference according to the groups (p < 0.01) Metalloproteinase-13 (MMP-13) in histological staining for evaluating cartilage healing and healing levels showed statistically significant differences between the groups at first week and fourth week (p < 0.05). DISCUSSION Vitamin D, which affects many tissues through its receptors, is believed to be chondroprotective and neuroprotective by decreasing the expression of MMP in cartilage fibroblast, macrophage, lymphocyte through its intracellular receptors. To the best of our knowledge, this is the first study known to be intraarticular use of 1 alpha, 25-dihydroxyvitamin D3. Our study has been found to be safe and successful in terms of weight, systemic PTH and 1 alpha, 25-dihydroxyvitamin D3 levels in rats during treatment as well as better healing of cartilage damage.
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    Compression neuropathy of the common peroneal nerve caused by an intraosseous ganglion cyst of fibula
    (Elsevier Sci Ltd, 2017) Kara, Adnan; Yalçın, Sercan; Çelik, Haluk; Kuyucu, Ersin; Şeker, Ali
    We present a case of a compression neuropathy of the common peroneal nerve caused by an intraosseous Ganglion cyst of fibula.
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    Difference between biomarkers of tibial bone marrow and adipose tissue
    (Edp Sciences S A, 2017) Kuyucu, Ersin; Erdil, Mehmet; Kara, Adnan; Bülbül, Murat
    Background: Stem cells, with their regeneration capacity, long-term viability, and differentiation characteristics, have indispensable biological properties. As described by Hauner and Grigoradis et al., mesenchymal stem cell originating from adipose or bone marrow can be differentiated into many tissues such as adipocyte, chondrocyte, myeloblast, and osteoblast. Our aim with this study is to compare the use of adipose and tibial bone marrow derived stem cells for therapeutic purposes in orthopedic surgery, which has not been clearly evaluated in the literature to our knowledge and to also evaluate their use. Material and method: Our study was performed between May 2014 and December 2016 in our clinic (Istanbul Medipol University, Department of Orthopedics and Traumatology) in 40 patients. Twelve patients were excluded. The ages of the 28 included patients ranged from 19 to 61 years, with a mean of 41.18 +/- 13.39 years. The stem cell samples of these patients were analyzed by flow cytometry. Results: Tibial bone marrow stem cells were used in 15 cases and the mean age was 49.33 +/- 9.15. Adipose-derived stem cells were used in 13 patients and the mean age was 31.77 +/- 11.25. None of the patients had any minor/major complication in the areas where stem cells were collected. Discussion: Tibial-derived bone marrow has better results with regard to the complications, economic burden, and surgery time. Tibial-derived bone marrow harvesting and stem cell preparation time are one-fourth of the stem cell treatment prepared from adipose tissue and the surgical duration is shortened by 45 min. Conclusion: If stem cell use is the preference of the surgeon, we have found that the tibial-derived stem cell system is more advantageous for ease of acquisition, cost analysis, and surgical time.
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    Does pelvic injury trigger erectile dysfunction in men?
    (Elsevier, 2015) Ceylan, Hasan Hüseyin; Kuyucu, Ersin; Erdem, Remzi; Polat, Gökhan; Yılmaz, Ferit; Gümüş, Bilal; Erdil, Mehmet Emin
    Purpose: Pelvic ring fractures constitute 3%-8% of all fractures of the skeletal system and are generally related with high energy trauma. Sexual dysfunction following pelvic fracture has a high incidence, and affects the male patients both physically and psychologically. In this study, we aimed to investigate the impact and frequencies of comorbidities such as erectile dysfunction (ED) with adverse sociocultural and psychological consequences for the patient who had a pelvic ring fracture. Methods: This study included 26 men who corresponded to the inclusion criteria and agreed to participate our study. Results: According to fracture types, most of our cases were Tile type A1 and type A2. Severe and moderate ED were detected in 46.1% (12/26) of these patients via the International Index of Erectile Function-5 questionnaire. Conclusion: ED develops following pelvic fractures, especially in Tile type B and C pelvic fractures.
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    Effect of oxytocin administration on nerve recovery in the rat sciatic nerve damage model
    (BioMed Central, 2015) Gümüş, Bilal; Kuyucu, Ersin; Erbaş, Oytun; Kazımoğlu, Cemal; Oltulu, Fatih; Arslan Bora, Osman
    Background: Growth factors such as nerve growth factor (NGF) and insulin-like growth factor-1 (IGF-1) have been shown to play a role in the healing process of nerve injury. Recent researches have also shown that oxytocin administration activates these growth factors of importance for the healing of nerve tissue. The objective of the present study was to evaluate the effects of oxytocin on peripheral nerve regeneration in rats. Methods: Twenty-four male Sprague-Dawley rats were underwent transection damage model on the right sciatic nerve and defective damage model on the left sciatic nerve. The animals were assigned to one of two groups: control group or treatment group (received 80 mg/kg oxytocin intraperitoneally for 12 weeks). The sciatic nerve was examined, both functionally (on the basis of climbing platform test) and histologically (on the basis of axon count), 3, 6, 9, and 12 weeks after the injury. Also, stereomicroscopic and electrophysiological evaluations were carried out. Results: Significantly greater improvements in electrophysiological recordings and improved functional outcome measures were presented in the treatment group at 12-week follow-up. Stereomicroscopic examinations disclosed prominent increases in vascularization on proximal cut edges in the oxytocin group in comparison with the control group. Higher axon counts were also found in this group. Conclusion: Intraperitoneal oxytocin administration resulted in accelerated functional, histological, and electrophysiological recovery after different sciatic injury models in rats.
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    Effectiveness of supervised resistive exercise and home-based exercise training on lower limb muscle strength in patients with knee osteoarthritis: A long-term comparative study
    (Elsevier Science Ltd, 2016) Baş Aslan, Ümmühan; Pekesen Kurtça, Mine; Koçyiğit, Figen; Koçyiğit, Ali; Kuyucu, Ersin
    Twenty-six patients with knee OA (Kellgren & Lawrence grade 2 or 3), aged 53,86 ± 5,33 years participated in this study. All of the patients were informed about OA risk factors, pathogenesis, prognosis, modification of daily living activities during a 2-hour long patient education lecture. Participants were then assigned at random to one of two groups as home-based strength training group (HEG) (n ¼ 13) and resistive exercise training group (REG) (n ¼ 13). Both exercise programs include the same or similar exercises and aimed at increasing lower limb strength (hip, knee and ankle muscles). All subjects performed three months exercise training. The subjects in the HEG were given strength exercise training and instructed to perform the exercise program three times a week for three months at home. And also, they received one session monthly supervised exercise training for progression. Progression in exercise training obtained with elastic bant. The REG received a supervised program three times a week for three months at indoor resistive exercise station. Patients in both groups performed 10 minutes warm-up period and cool-down period. The strength of quadriceps femoris, hamstrings, hip abductors, hip adductors, and gastrocnemius muscles assessed by using handheld dynamometry by the same investigator. Muscle strength of participants was assessed at baseline, 12 weeks and 24 weeks (follow-up).
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    Effects of lower limb exercise training with whole body vibration on femoral articular cartilage in patients with knee osteoarthritis
    (Elsevier Sci Ltd, 2016) Pekesen Kurtça, Mine; Baş Aslan, Ümmühan; Koçyiğit, Figen; Koçyiğit, Ali; Kuyucu, Ersin
    Osteoarthritis (OA) is the most common degenerative joint disease leading to typical degradation of articular cartilage. Vibrations produced in oscillating/vibratory platform generate whole body vibration (WBV) exercises, which are important in sports, as well as in physiotherapy treatment. WBV exercise is a mechanically and biologically potential stimulus and a feasible, curative strength-exercise technique. Validity and reproducibility of ultrasonography (US) in detecting joint structural pathology in OA was reported. The aim of this study was to investigate the effects of lower-limb exercise training with WBV on femoral articular cartilage thickness in patients with knee OA by using US.
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    Erector spinae plane block vs interscalene brachial plexus block for postoperative analgesia management in patients who underwent shoulder arthroscopy
    (BMC, 2022) Kapukaya, Furkan; Ekinci, Mürsel; Çiftçi, Bahadır; Atalay, Yunus Oktay; Gölboyu, Birzat Emre; Kuyucu, Ersin; Demiraran, Yavuz
    Background Interscalene brachial plexus block (ISB) is the gold standard method used for postoperative analgesia after arthroscopic shoulder surgery. Ultrasound guided erector spinae plane block (ESPB) is an interfascial plane block. The aim of this study is to compare the analgesic efficacy of ESPB and ISB after shoulder arthroscopy. The primary outcome is the comparison of the perioperative and postoperative opioid consumptions. Methods Sixty patients with ASA score I-II planned for arthroscopic shoulder surgery were included in the study. ESPB was planned in Group ESPB (n = 30), and ISB was planned in Group ISB (n = 30). Intravenous fentanyl patient-controlled analgesia was administered to both groups in the postoperative period. Intraoperative and postoperative opioid and analgesic consumption of both groups, side effects and complications related to opioid use, postoperative pain scores and rescue analgesic use were recorded in the first 48 h postoperatively. Results Pain scores were significantly higher in the ESPB group in the first 4 h postoperatively than in the ISB group (p < 0.05). The total fentanyl consumption and number of patients using rescue analgesics in the postoperative period were significantly higher in the ESPB group (p < 0.05). The incidence of nausea in the postoperative period was significantly higher in the ESPB group (p < 0.05). Conclusions In our study, it was seen that ISB provided more effective analgesia management compared to ESPB in patients underwent shoulder arthroscopy surgery.
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    Exenatide promotes regeneration of injured rat sciatic nerve
    (Wolters Kluwer Medknow Publications, 2017) Kuyucu, Ersin; Gümüş, Bilal; Erbaş, Oytun; Oltulu, Fatih; Bora, Arslan
    Damage to peripheral nerves results in partial or complete dysfunction. After peripheral nerve injuries, a full functional recovery usually cannot be achieved despite the standard surgical repairs. Neurotrophic factors and growth factors stimulate axonal growth and support the viability of nerve cells. The objective of this study is to investigate the neurotrophic effect of exenatide (glucagon like peptide-1 analog) in a rat sciatic nerve neurotmesis model. We injected 10 mg/d exenatide for 12 weeks in the experimental group (n = 12) and 0.1 mL/d saline for 12 weeks in the control group (n = 12). We evaluated nerve regeneration by conducting electrophysiological and motor functional tests. Histological changes were evaluated at weeks 1, 3, 6, and 9. Nerve regeneration was monitored using stereomicroscopy. The electrophysiological and motor functions in rats treated with exenatide were improved at 12 weeks after surgery. Histological examination revealed a significant increase in the number of axons in injured sciatic nerve following exenatide treatment confirmed by stereomicroscopy. In an experimentally induced neurotmesis model in rats, exenatide had a positive effect on nerve regeneration evidenced by electromyography, functional motor tests, histological and stereomicroscopic findings.