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Öğe A survey of bullous diseases in a Turkish university hospital: Clinicoepidemiological characteristics and follow-up(Türkiye Klinikleri, 2021) Kutlubay, Zekayi; Sevim Keçici, Ayşegül; Çelik, Uğur; Mat, CemBackground/aim: Autoimmune bullous diseases, if left untreated, are life-threatening conditions affecting primarily skin and mucous membranes. These blistering disorders are characterized by epidermal or subepidermal detachment. Autoimmunity plays a key role in pathogenesis; therefore, immunosuppressive agents are the treatment of choice. The aim of this study is to document relative frequencies of different autoimmune bullous diseases, patient characteristics, treatment options, and side effects in patients presenting to our bullous skin disease center at İstanbul University, Cerrahpaşa, Cerrahpaşa Medical Faculty. Materials and methods: Medical files were examined retrospectively for all patients with autoimmune bullous diseases who were followed up between 2003 and 2019 at the Bullous Skin Disease Center at İstanbul University, Cerrahpaşa. Results: A total of 346 patient files were examined. Pemphigus vulgaris was the most frequent autoimmune bullous disease, followed by bullous pemphigoid and pemphigus foliaceus, according to our study. There is a general female predominancy for all autoimmune bullous diseases. The most commonly preferred treatment options were high-dose daily corticosteroids. Conclusion: This retrospective study summarizes the patient characteristics, comorbidities, treatment choices, and side effects during 16 years of clinical practice.Öğe Acral manifestations of fungal infections(Elsevier Science Inc., 2017) Kutlubay, Zekayi; Yardımcı, Gürkan; Kantarcıoğlu, A. Serda; Serdaroğlu, ServerFungal infections, which are named according to the body site involved, can affect any skin area, the fingemails, or the toenails. Numerous fungal agents are responsible for both superficial and deep fungal diseases. Dermatophytes and Candida spp are the most common causative organisms on the surface of the hands, feet, and nails of patients with superficial fungal diseases; however, although deep fungal infections of the skin are less common compared with superficial fungal diseases, their incidence is increasing worldwide due to cross-border travel. Most superficial fungal diseases are diagnosed clinically, but sometimes direct microscopic examination with potassium hydroxide and fungal culture may be necessary for diagnosis, especially in patients suspected of having tinea incognito. In cases of superficial fungal infections except for onychomycosis and tinea incognito, topical treatments are usually sufficient and effective, but systemic treatments may be required in recalcitrant cases. Deep fungal diseases may resemble each other clinically; therefore, the organism must be identified with laboratory methods and should be treated for a long period. We review the most important clinical, diagnostic, and therapeutic aspects of fungal diseases. This paper covers fungal problems encountered both in hospitals and in general practice.Öğe An unusual case of erythema annulare centrifugum involving face(Pakistan Association of Dermatologists, 2021) Pekmezci, Erkin; Küçükodacı, Zafer; Kutlubay, ZekayiErythema annulare centrifugum (EAC) is a reactive figurate erythematous disease characterised by gyrate and annular plaques with erythema. The disease is generally known as involving the extremities and trunk, but sparing the face. We present a young male patient with recurring annular erythematous scaly lesions on his face, frequently in a year since four years, with no systemic involvement. Histologically, in addition to slight parakeratosis and spongiosis in the epidermis, there was superficial lymphocytic and histiocytic perivascular infiltration with the classic coat sleeve appearance of EAC in the dermis. Although uncommon, we suggest EAC should be considered in the differential diagnosis of relevant lesions on face.Öğe Cutaneous metastases from breast carcinoma - multiple clinical presentations(Termedia Publishing House Ltd, 2021) Pekmezci, Erkin; Küçükodacı, Zafer; Kutlubay, ZekayiCutaneous metastases usually appear as nonspecific groups of discrete, firm, painless nodules that emerge rapidly without any explanation. Some skin metastases may mimic specific dermatological conditions such as cutaneous cysts, dermatofibroma, granuloma teleangiectodes, hemangioma, herpes zoster eruptions, rapidly infiltrating plaques, alopecic patches, erysipelas and cellulitis [1].
