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Öğe A case of unresolved skin lesion in a cobbler(2024) Mert, Ali; Kaya, Abdurrahman; Yıldız Kaya, Sibel[Abstract Not Available]Öğe A man with recurrent axillary abscess(2025) Durmaz, Gamze; Beycan, Esin; Kaya, Abdurrahman; Mert, Ali...Öğe A woman with lip lesion and submandibular lymphadenopathy(Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica, 2022) Kaya, Abdurrahman; Kaya, Sibel Yıldız; Durmaz, Gamze; Mıkayılova, Nurlana[Abstract Not Available]Öğe Acute acalculous cholecystitis due to hepatitis b virus reactivation: a case report and review of the literature(2024) Kaya, Abdurrahman; Beycan, Esin; Kaya, Sibel Yıldız; Özdemir, Gülhan; Zerdali, Hasan; Mert, AliWe report a 52-year old man presenting with acute acalculous cholecystitis triggered by hepatitis B virus infection. The patient developed protective antibodies and cleared the infection. The relevant data is also discussed.Öğe Change in species distribution and antifungal susceptibility of candidemias in an intensive care unit of a university hospital (10-year experience)(Springer, 2021) Mete, Bilgül; Yerlikaya Zerdalı, Esra; Aygün, Gökhan; Saltoğlu, Neşe; Balkan, İlker İnanç; Karaali, Rıdvan; Kaya, Sibel Yıldız; Karaismailoğlu, Berna; Kaya, Abdurrahman; Ürkmez, Seval; Can, Günay; Tabak, Fehmi; Öztürk, RecepCandidemia is a nosocomial infection mostly found in critically ill patients. Our objectives were to evaluate the change in distribution and resistance profile ofCandidaspp. isolated from candidemic patients in our intensive care unit over two 5-year periods spanning 15 years and to evaluate the risk factors. Records from the microbiology laboratory were obtained, from January 2004 to December 2008 and from January 2013 to December 2017, retrospectively. Antifungal susceptibility was performed by E-test and evaluated according to EUCAST breakpoints. A total of 210 candidemia cases occurred; 238Candidaspp. were isolated in 197 patients (58.8% male; mean age, 59.2 +/- 19.6 years). The most predominant risk factor was central venous catheter use. Species distribution rates were 32%, 28%, 17%, and 11% forC. albicans(n = 76),C. parapsilosis(n = 67),C. glabrata(n = 40), andC. tropicalis(n = 27), respectively. Resistance rate to anidulafungin was high inC. parapsilosisover both periods and increased to 73% in the second period. Fluconazole showed a remarkable decrease for susceptibility inC. parapsilosis(94 to 49%). The prevalence of MDRC. parapsilosis(6%/33%) andC. glabrata(0%/44%) increased in the second period. We observed a predominance of non-albicansCandidaspp., withC. parapsilosisbeing the most frequent andC. glabratainfections presenting with the highest mortality. High level of echinocandin resistance inC. parapsilosisand increasing prevalences of MDRC. parapsilosisandC. glabrataseem emerging challenges in our institution.Öğe Clinical and microbiological characteristics of Aeromonas bacteremia in Turkey(Akademiai Kiado Zrt, 2021) Kaya, Abdurrahman; Yıldız Kaya, Sibel; Zerdali, Esra; Koç, Alper; Çağlar, Bilge; Ertürk, Ümran Şümeyse; Yılmaz, Mesut; Aygün, Gökhan; Balkan, İlker İnanç; Mete, Bilgül; Saltoğlu, Neşe; Mert, Ali; Tabak, Ömer FehmiWe investigated the cases with Aeromonas bacteremia in terms of clinical and microbiological characteristics, underlying disease and mortality rates. Patients with positive blood cultures were included in this research. Aeromonas bacteremia was diagnosed as at least one positive blood culture for Aeromonas species. The bacteremia was defined as community origin if the onset was in the community or within 72 hours of hospital admission. The others were considered as nosocomial. All bacteria were defined as Aeromonas with conventional method. Species identification was verified by VITEK system. Antibiotic susceptibility tests were analyzed with the disc diffusion, E-test method or VITEK system. Thirty-three patients were diagnosed with bacteremia due to Aeromonas spp. Hematologic and solid tumors were the leading underlying conditions, followed by cirrhosis. Two patients (6%) had community-acquired infections. Aeromonas hydrophila was the most common isolated bacterium. The crude mortality rate was 36%. 12 patients died and 6 deaths and 4 deaths were detected in patients with bacteremia caused by A. hydrophila and Aeromonas sobria respectively. All strains were resistant to ampicillin and more than 90% of the strains were susceptible to trimethoprim-sulfamethoxazole, fluoroquinolone, third generation cephalosporins, and carbapenems. Aeromonas sp. is not a frequent cause of bacteremia however, it may lead to high mortality rates, especially in the immunocompromised hosts and patients with liver cirrhosis. Nosocomial Aeromonas bacteremia is not uncommon in these populations. Broad-spectrum cephalosporins, piperacillin-tazobactam, fluoroquinolones, and carbapenems remain as effective antimicrobial agents for therapy of Aeromonas bacteremia.Öğe Eosinophilic lymph node abscesses following a COVID-19 vaccination: A case report(National Medical Association, 2023) Kaya, Abdurrahman; Kaya, Sibel Yıldız; Abul, Azat; Fener, Neslihan; Can, Ali; Mert, AliIn this paper, we reported a 37-year-old man who developed several lymphadenopathies after using the second dose of Pfizer-BioNtech vaccination against SARS-CoV-2. The excisional lymph node biopsy showed eosinophil-rich inflammation with micro-abscesses. Although eosinophilic dermatosis and eosinophilic myocarditis have been described previously following COVID-19 vaccinations, eosinophilic lymph node abscess was not reported in the literature. In our case, all lesions were completely recovered with steroid treatment. The patient has been doing well and no recurrence has been observed for six months.Öğe First case of intravenous drug use-related candidemia in Türkiye(2024) Kaya, Abdurrahman; Zerdali, Hasan; Koç, Buse; Tozalgan, Ümit; Çiftçi, Can; Mert, AliAlthough Candida species are normal flora elements of the body, they can cause various diseases from mucocutaneous infections to candidemia. The presence of a central venous catheter, use of broad-spectrum antibiotics, parenteral nutrition, dialysis, neutropenia, malignancy, and immunosuppressive treatments are the most reported risk factors for candidemia. Complications that develop during follow-up increase both morbidity and mortality. The incidence of fungal infections has been increasing in recent years. This increase is also seen in intravenous drug users. In these patients, candidemia can cause serious life-threatening complications including septicemia and end-organ failure. To date, no cases of intravenous drug use-related candidemia have been reported in our country. This patient represents the first documented case. In this case, we aim to draw attention to the relationship between intravenous drug use and candidemia.Öğe HCV-specific lymphocyte responses in individuals with positive anti-HCV but negative HCV-RNA(Elsevier Science, 2015) Sili, Uluhan; Kaya, Abdurrahman; Aydın, Selda; Hondur, Nur; Mert, Ali; Tabak, Fehmi; Özaras, Reşat; Öztürk, RecepBackground: Hepatitis C virus (HCV) status cannot be reliably predicted in anti-HCV positive/HCV-RNA negative individuals who may either have recovered spontaneously or have a false-positive test due to antibody cross-reaction. Investigating T lymphocyte responses in individuals with different HCV status may help understand the cellular immune mechanisms underlying spontaneous recovery, treatment response, and chronicity. Objective: We aimed to determine whether anti-HCV positive, HCV-RNA negative individuals are truly spontaneous recoverers from acute HCV infection. Study design: We used enzyme-linked immunosorbent spot (ELISPOT) assay to compare HCV-specific lymphocyte response among anti-HCV positive/HCV-RNA negative individuals, patients with sustained virological response to interferon-gamma/ribavirin treatment, and patients with chronic HCV infection. Results: We found that 83% of anti-HCV positive/HCV-RNA negative individuals without a past medical history of acute icteric hepatitis had an HCV-specific T lymphocyte response in peripheral blood. Lymphocyte responses in these individuals were similar in magnitude to treatment responders unlike patients with chronic HCV whose virus-directed immunity was significantly suppressed. Conclusions: Detection of HCV-specific T lymphocyte responses using ELISPOT is a feasible method to ascertain past asymptomatic acute HCV infection.Öğe Herpes simplex virus encephalitis: Clinical manifestations, diagnosis and outcome in 106 adult patients(Elsevier, 2014) Sili, Uluhan; Kaya, Abdurrahman; Mert, Ali; Özaras, Reşat; Midilli, Kenan; Albayram, Sait; Kenangil, Gülay; Demirci, Onat; Kapmaz, Mahir; Kart Yaşar, Kadriye; Özyavuz Alp, Şehnaz; Ünal Kayaaslan, BircanBackground: Herpes simplex virus (HSV) is one of the most common causes of sporadic encephalitis worldwide. Objective: We aimed to determine clinical characteristics and prognosis of HSV encephalitis (HSVE) cases reviewed retrospectively from several collaborating centers. Study design: We searched hospital archives of the last 10 years for patients with HSVE diagnosis, i.e. clinical presentation compatible with encephalitis and brain involvement on magnetic resonance imaging (MRI) and/or detection of HSV DNA in the cerebrospinal fluid by polymerase chain reaction (PCR). Clinical characteristics were noted and patients were phone-interviewed. HSVE cases were grouped and analyzed as proven and probable, based on virological confirmation by PCR. Univariate and multivariate analyses were used to determine factors associated with prognosis. Results: A total of 106 patients (63 males and 43 females; mean age, 44 years; range, 18-83 years) were included. Most common symptoms were changes in mental status, fever, headache, and seizure. HSV PCR was positive in 69% of patients tested, while brain involvement was detected on MRI in 95%. Acyclovir was started mostly within five days of main symptom and continued for >= 14 days. Case fatality rate was 8%, while 69% of patients recovered with sequelae. Favorable prognosis was observed in 73% of patients. Multivariate analysis identified the duration of disease before hospital admission (odds ratio (OR) = 1.24) and the extent of brain involvement on MRI at the time of admission (OR = 37.22) as two independent risk factors associated with poor prognosis. Conclusions: Although HSVE fatality regressed considerably with acyclovir treatment, many patients survive with sequelae. Our results emphasize the importance of early diagnosis and prompt treatment of HSVE.Öğe Paradoxical psoas and subcutaneous abscesses developing on anti-tuberculous treatment: A case report and literature review(National Medical Association, 2023) Kaya, Abdurrahman; Altınkaynak, Merve; Keskin, Feyza; Özdemir, Gülhan; Yıldız Kaya, Sibel; Mert, AliTuberculosis (TB) is an infectious disease which has different clinical presentations. Paradoxical reaction (PR) is defined as the temporary aggravation of present TB lesions or the emergence of new lesions despite adequate anti-TB therapy. 1 , 2 Although the pathogenesis of this phenomenon is not fully elucidated, it is presumed to be a delayed-type hypersensitivity reaction to tuberculo-proteins. PR can be seen in different rates based on clinical forms of TB disease. 1 It is reported with the rate of 25% in TB lymphadenitis but lower rate in other forms of TB. 3 , 4 PR is very rare in spinal TB infection. 1 In this report, an immunocompetent patient who developed recurrent psoas and subcutaneous abscesses during the 10 th month of TB-treatment was described. Additionally, relevant literature was reviewed and extra-nodal paradoxical tuberculous abscesses in English were discussed among HIV-negative patients. To our knowledge, this is the largest paradoxical tuberculous abscesses ever reported.Öğe Primary tuberculous pyomyositis of the left forearm muscles(2024) Mert, Ali; Aydın, Selda; Kaya, AbdurrahmanPyomyositis, often caused by Staphylococcus aureus, is a rare primary infection of skeletal muscle and is usually associated with abscess formation. Pyomyositis caused by Mycobacterium tuberculosis is extremely rare. In this paper, by presenting a case of tuberculous pyomyositis, we tried to provide a simple answer to the question of when we should consider M. tuberculosis in the etiology of pyomyositis.Öğe Reactivation of cutaneous tuberculosis induced by trauma: A case report(2024) Mert, Ali; Kaya, Abdurrahman; Kaya, Sibel Yıldız[Abstract Not Available]
