Yazar "Karavas, Evangelos" seçeneğine göre listele

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    Surface modified multifunctional and stimuli responsive nanoparticles for drug targeting: Current status and uses
    (MDPI, 2016) Siafaka, Panoraia I.; Okur Üstündağ, Neslihan; Karavas, Evangelos; Bikiaris, Dimitrios N.
    Nanocarriers, due to their unique features, are of increased interest among researchers working with pharmaceutical formulations. Polymeric nanoparticles and nanocapsules, involving non-toxic biodegradable polymers, liposomes, solid lipid nanoparticles, and inorganic-organic nanomaterials, are among the most used carriers for drugs for a broad spectrum of targeted diseases. In fact, oral, injectable, transdermal-dermal and ocular formulations mainly consist of the aforementioned nanomaterials demonstrating promising characteristics such as long circulation, specific targeting, high drug loading capacity, enhanced intracellular penetration, and so on. Over the last decade, huge advances in the development of novel, safer and less toxic nanocarriers with amended properties have been made. In addition, multifunctional nanocarriers combining chemical substances, vitamins and peptides via coupling chemistry, inorganic particles coated by biocompatible materials seem to play a key role considering that functionalization can enhance characteristics such as biocompatibility, targetability, environmental friendliness, and intracellular penetration while also have limited side effects. This review aims to summarize the state of the art of drug delivery carriers in nanosize, paying attention to their surface functionalization with ligands and other small or polymeric compounds so as to upgrade active and passive targeting, different release patterns as well as cell targeting and stimuli responsibility. Lastly, future aspects and potential uses of nanoparticulated drug systems are outlined.
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    Two different approaches for oral administration of voriconazole loaded formulations: Electrospun fibers versus beta-cyclodextrin complexes
    (MDPI, 2016) Siafaka, Panoraia I.; Okur Üstündağ, Neslihan; Mone, Mariza; Giannakopoulou, Spyridoula; Er, Sevda; Pavlidou, Eleni; Karavas, Evangelos; Bikiaris, Dimitrios N.
    In this work, a comparison between two different preparation methods for the improvement of dissolution rate of an antifungal agent is presented. Poly(epsilon-caprolactone) (PCL) electrospun fibers and beta-cyclodextrin (beta-CD) complexes, which were produced via an electrospinning process and an inclusion complexation method, respectively, were addressed for the treatment of fungal infections. Voriconazole (VRCZ) drug was selected as a model drug. PCL nanofibers were characterized on the basis of morphology while phase solubility studies for beta-CDs complexes were performed. Various concentrations (5, 10, 15 and 20 wt %) of VRCZ were loaded to PCL fibers and beta-CD inclusions to study the in vitro release profile as well as in vitro antifungal activity. The results clearly indicated that all formulations showed an improved VRCZ solubility and can inhibit fungi proliferation.