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  • Küçük Resim
    Öğe
    Prematür akut koroner sendrom hastalarında yüksek serum interlökin-17A düzeyi
    (Turkiye Klinikleri, 2015) Demir, Bülent; Ünğan, İsmail; Oflar, Ersan; Khankishiyev, Vüsal; Pirhan, Osman; Demir, Esra; Özbek, Hanefi; Karakaya, Osman
    Amaç: Prematür akut koroner sendrom geçiren hastalarda serum interlökin (IL)-17A düzeyinin değerlendirilmesidir. Gereç ve Yöntemler: Aralık 2013-Ocak 2015 tarihleri arasında hastanemiz acil servisine başvuran ve akut koroner sendrom tanısı alan 45 yaş altında, ardışık seçilen 45 (35 erkek, 10 kadın, ortalama yaş; 39,6±3,85 yıl) hasta, prematür akut koroner sendrom hasta grubu olarak alındı. Koroner anjiyografi sonucu normal koroner arter olarak saptanan ve ardışık seçilen 35 (19 erkek, 16 kadın, ortalama yaş 40,1±3,37 yıl) hasta ise kontol grubu olarak belirlendi. Prematür hasta grubunda koroner lezyonların yaygınlığını belirlemek için ise Syntax skoru hesaplandı. Serum IL-17A düzeyleri ELISA yöntemi ile belirlendi. Bulgular: Hasta grubunda erkek cinsiyet ve sigara içiciliği kontrol grubuna göre daha yüksek idi (Her ikisi için; p<0,05). Koroner arter hastalığı için aile öyküsü varlığı kontrol grubunda hasta grubuna göre istatistiksel anlamlı olarak daha yüksek bulundu (p=0,003). Plazma trigliserid düzeyi, beyaz küre sayısı, nötrofil sayısı, nötrofil/lenfosit oranı hasta grubunda kontrol grubuna göre istatistiksel anlamlı olarak yüksek saptandı (hepsi için p<0,05). Fakat plazma HDL düzeyi, hasta grubunda kontrol grubuna göre düşüktü (p=0,001). Serum IL-17A düzeyi hasta grubunda kontrol grubuna göre daha yüksekti (sırasıyla; 2,0±1,88 pg/mL, 0,9±1,86 pg/mL, p=0,0001). Fakat hs-CRP düzeyi açısından iki grup arasında istatistiksel anlamlılık saptanmadı (sırasıyla; 4,4±5,61 mg/L, 2,7±6,19 mg/L, p=0,050). Sonuç: IL-17A proinflamatuar özelliği ile prematür akut koroner sendrom gelişiminde rol oynuyor olabilir.
  • Küçük Resim
    Öğe
    The relationship between adiponectin levels and epicardial adipose tissue thickness in non-obese children with asthma
    (Allergy and Immunology Society of Thailand, 2015) Özde, Cem; Do?ru, Mahmut; Erdo?an, Fırat; İpek, İlke Özahi; Özde, Şükriye; Karakaya, Osman
    Background: There is an association between adiponectin (APN) and asthma. However, the mechanisms underlying this association is unclear. APN is a predominantly antiinflammatory protein with possible signalling activity in the lung that can be secreted by Epicardial Adipose Tissue (EAT). Our hypothesis is that serum APN levels may be directly and simply related to the amount of EAT accumulation, particularly when it is expressed as thickness in children with asthma. Objective: The aim of this study was to investigate whether serum adiponectin (APN) and epicardial adipose tissue thickness (EATT) have an effect in non-obese children with asthma and in healthy non-asthmatic children, and analyze their relationships with clinical outcomes. Methods: 68 childrens diagnosed with asthma (20 girls/48 boys) who had applied at the pediatric allergy and clinical immunology clinic of the hospital were included in this cross-sectional, observational study. The age-matched control group included 39 healthy children (18 girls/21 boys). EATT was measured by transthoracic echocardiography. The serum APN levels were also checked. Statistical analysis was performed by using independent sample t-test and Spearman correlation analyses. Results: The mean age of the asthma group was 10.2 ± 2.7 years, and the average EATT was found to be 5.7±1.1 mm. The mean age of the control group was 10.5 ± 2.8 years, and the average EATT was found to be 5.1 ± 0.7 mm. The EATT of the asthma group was found to be significantly higher (p < 0.001) in study group. In the asthma group the APN was 10.0 ± 5.3 mg/L, and in the control group the APN was 15.8 ± 10.5 mg/L (p < 0.001). We found that APN was significantly negatively correlated with EATT (r = -0.266, p = 0.006) in asthma and control groups. Conclusion: EATT is associated with non-obese asthmatic childrens. High EATT may be related with high release of pro-inflammatory cytokine and low release of APN. Low levels of APN may be related to low anti-inflammatory effects. Therefore, high EATT and low levels of APN may indicate pro-inflammantory profiles in nonobese asthmatic childrens. © 2009 is a Digital Portal of health science journals in Thailand.