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    An investigation on production routes of U-230 radioisotope used in targeted alpha therapy by different level density models
    (Pleiades Publishing Inc, 2022) Özdoğan, Hasan; Şekerci, Mert; Cinoğlu Karaca, Merve; Okutan, Murat; Demir, Bayram; Kaplan, Abdullah
    Targeted alpha therapy (TAT) is an attractive therapeutic option in patients with multiple micrometastases. It offers many advantages, including easy administration, the ability to treat multiple lesions simultaneously and the possibility of combination with other therapeutic approaches for improved efficacy. The aim of this study is to investigate the optimum production route of U-230, which is a promising TAT isotope, in cyclotrons. For this, Pa-231(p, 2n)U-230, Pa-231(d, 3n)U-230, Th-232(p, 3n)Pa-230, and Th-232(d, 4n)Pa-230, reactions cross-sections, total activity and reaction yield have been calculated by using different level density models of TALYS 1.95 code. It is possible to produce an U-230 activity of 53.491 mCi via on Pa-231(p, 2n)U-230 direct route with 12.8 MeV protons at 1 mA current for 24 h. After a 28 days waiting period required for undesirable product (U-230) activity to decrease sufficiently, this activity decreases to 21.4 mCi and by considering the average dose per patient as 0.5 mCi, these activities are enough for 43 patients. Besides, Pa-231 is already the target material in this direct production route and Pa-231 obtained from undesirable product U-231 can be stored and processed for re-use as the target material. In this way, a significant amount of source material can be recovered.
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    Distorted assessment of left atrial size by echocardiography in patients with increased aortic root diameter
    (Springer, 2021) Kaplan, Abdullah; Altara, Raffaele; Manca, Marco; Güneş, Hacı Murat; Cataliotti, Alessandro; Booz, George W.; Zouein, Fouad A.
    Background: Left atrial (LA) size is frequently assessed by posterior-anterior linear measurement of LA (LAD P-A) in the parasternal long axis to expedite examination. Aging, changes in body surface area, and several cardiovascular pathologies can affect aortic root (AoR) size, thereby affecting LA anatomical shape. We hypothesized that AoR dilatation influences LAD P-A and consequently correct assessment of LA size. Results: We tested our hypothesis in a study of 70 patients with AoR diameter ranging from 2.7 to 4.8 cm. LA size assessed in parasternal long axis view as LAD P-A was compared to that with LA width and length acquired in the apical two and four chamber view. Simpson's method of discs was used as standard measurement to assess LA volume. We observed that LAD P-A in the parasternal long axis decreases when AoR diameter increases. Thus, the increase in LA size assessed in parasternal long axis did not correlate with the increase of LA volume. Further analysis revealed that a significant positive correlation was observed when LAV was plotted as a function of LAD P-A only for those with a normal size AoR. In contrast, LA volume increase correlated with LA diameters assessed in the apical two and four chamber view regardless of AoR size. Conclusions: Our study documents that increases in AoR impact on the linear measurement of LA, resulting in an underestimated LAD P-A. LA size ought to be calculated from the apical two and four chambers view parameters, especially in patients with AoR dilatation.
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    Resembling left ventricular false tendon in a father and his daughter
    (Hindawi Ltd, 2018) Kaplan, Abdullah; Güneş, Hacı Murat
    Left ventricular false tendons (LVFTs) are linear fibrous or fibromuscular bands stretching across left ventricular cavity. Although LVFTs have been associated with various heart pathologies and investigated embryologically and histologically, there is only one report in the literature connoting possible hereditary transmission of this entity. We reported a father and his daughter having similar types of LVFTs with regard to location and thickness. With this report, we will contribute in the literature in respect to potential genetic inherence of LVFTs.