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    Do restoring and maintaining sinus rhythm have a beneficial effect on secondary prevention of stroke in patients with atrial fibrillation? A pilot study
    (SAGE Publications Inc., 2019) Conkbayır, Cenk; Yiğit, Zerrin; Hural, Refika; Uğurlucan, Murat; Öztaş, Didem Melis; Ökçün, Barış; Küçükoğlu, Serdar
    We aimed to determine whether attempts to restore and maintain sinus rhythm will reduce recurrent stroke in patients with atrial fibrillation (AF). Patients (n = 245) between March 1998 and May 2002 with AF who had an ischemic stroke including transient ischemic attack 1 to 12 months before transesophageal echocardiographic examination and had been followed for 3 years were retrospectively reviewed. Cardioversion was attempted in 130 patients; 117 (90%) patients were successfully cardioverted (rhythm control group). The 13 patients who could not be cardioverted and 115 patients who did not undergo cardioversion were assigned to the rate control group. Age, gender, ischemic heart disease, hypertension, diabetes mellitus, congestive heart failure, mitral valve disease, and left atrial diameter were similar in both groups. The rhythm control group included 56 patients (48.7%) who were still in sinus rhythm after 3 years. During follow-up, there were 2 embolic events (3.4%) and 2 deaths (3.4%) in the rhythm control group, whereas 18 embolic events (14.6%) and 18 deaths (14.6%) occurred in the rate control group (P =.049 and P =.049, respectively). Restoration and maintenance of sinus rhythm seems to have a beneficial effect on secondary prevention of stroke in patients with AF.
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    Prevention of recurrent stroke: Response to the letter by arugaslan et al
    (Sage Publications Inc., 2020) Conkbayır, Cenk; Yiğit, Zerrin; Hural, Refika; Uğurlucan, Murat; Öztaş, Didem Melis; Ökçün, Barış; Küçükoğlu, Serdar
    Arugaslan et al raise some points in their letter entitled “Role ofRhythm Control in Prevention of Recurrent Stroke.”1As we report in our article, rhythm control strategy is associated with decreased rates of recurrent stroke in patients withatrial fibrillation (AF).2 Arugaslan et al1 mention that the average age in our study group is below 65 years. Atrial fibrillationis more problematic in elderly patients especially after cardioversion.3 The patients were randomly included in our study,2and we did not aim to select patients younger than 65 years.Hence, further studies are needed to study the characteristicsand course of AF in the elderly patients.
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    Recurrent thromboembolism prediction in atrial fibrillation: Response to letter by sener et al
    (Sage Publications Inc, 2020) Conkbayır, Cenk; Yiğit, Zerrin; Hural, Refika; Uğurlucan, Murat; Öztaş, Didem Melis; Okcun, Barış; Küçükoğlu, Serdar
    Sener et al in their letter entitled “Predicting Recurrent Thromboembolism in Atrial Fibrillation”1 raise some queries regarding our article.2We report in our article, that sinus rhythm restoration was abetter strategy than rate control to reduce recurrent ischemicstroke/transient ischemic attack rates in patients with atrialfibrillation (AF).2