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    A descriptive survey study to evaluate the relationship between socio-demographic factors and quality of life in patients with a permanent colostomy
    (HMP Communications, LLC, 2014) Kement, Metin; Gezen, Cem; Aydın, Halime; Haksal, Mustafa; Can, Uğur; Aksakal, Nihat; Öncel, Mustafa
    The impact of having a stoma on quality of life is increasingly recognized and studied. A descriptive survey study was conducted between January 2006 and December 2011 among 44 patients (18 women, 26 men) with a permanent stoma receiving care at the Kartal Training and Research Hospital, Istanbul, Turkey, to evaluate socio-demographic factors that may affect the quality of life in Turkish Muslim patients with an enteral stoma. A socio-demographic questionnaire, a 10-item Religious Orientation Scale (Modified Allport-Ross ROS), and the Medical Outcomes Study Short Form 36 Quality of Life survey were administered by a stoma therapy nurse at least 6 months after completion of all surgical and oncological treatments. The mean follow-up period was 15.3 +/- 9.7 (range 6-44) months since completion of all treatments. Data were collected using paper/pencil instruments and entered for data analysis using Student's t-tests or one-way ANOVA univariate and multivariate analyses. No significant differences were observed for income, education level, surgical history, or religion score. Gender, geographic region, and household status were found independently related to quality of life in stoma patients. Female patients had significantly lower scores than males in general health perception (P=0.049), role emotion (P=0.02), mental health perception (P=0.026), and mental component (P=0.007). Patients living in a village (four) had significantly lower scores than patients living in a big city (33) in all scales (P<0.05 for all comparisons). Village-dwelling patents also had significantly lower scores than patients living in a town (seven) in physical function (P =0.001), vitality (P=0.012), social function (P=0.003), and mental component scores (P=0.021). Patients living alone (seven) had significantly lower scores than patients living with a partner (11) in three of eight scales (physical functioning [P<0.001], role-physical [P=0.047], and bodily pain [P=0.015]) and physical component scores (P<0.001); they also had significantly lower scores than patients living with their families (26) in four of eight scales (physical functioning [P <0.001], role-physical [P=0.032], bodily pain [P=0.02], and general health perception [P=0.036]) and physical component scores (P<0.001). Although these findings provide evidence for the relationship between some socio-demographic factors on quality of life of patients with a stoma, the results of the study should be interpreted with caution; multicenter, prospective, controlled studies are needed to substantiate and clarify the relationships among these variables.
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    A rare cause of abdominal pain: Primary epiploic appendagitis (PEA)
    (2016) Erkan, Gülbanu; Gezen, Cem; Bilgin, Sabriye Şennur
    Primary epiploic appendagitis (PEA) is a rare disease caused by torsion or spontaneous thrombosis of the central vein that drains epiploic appendages (EA). Primary Epiploic Appendagitis (PEA) is an ischemic infarction. Although PEA is a self-limiting disease and does not require surgical intervention in most cases, it may mimic diseases that require surgical intervention or aggressive medical therapy, such as appendicitis, diverticulitis, or cholecystitis. In order to avoid unnecessary surgical intervention, PEA should be kept in mind when patients present with acute abdominal pain. In this report, we present a PEA case admitted with abdominal pain.
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    Laparoscopic and conventional incisional hernia repair: A retrospective analysis
    (Kocaeli Derince Training and Research Hospital, 2018) Haksal, Mustafa Celalettin; Gezen, Cem; Okkabaz, Nuri; Yılmaz, Merih; Öncel, Mustafa
    INTRODUCTION: To analyze the outcomes oflaparoscopic and open techniques in incisional herniarepair.METHODS: Patients’ charts with incisional herniawere retrospectively reviewed. Demographics, diseaseand operation related variables and short term outcomeswere compared between groups.RESULTS: Nineteen [12 female (63.2%), mean±SD ageof 53.5±15.1] of 33 patients were operated on with opentechnique, whereas 14 [11 female (78.5%), mean±SDage of 59.1±14.2] patients with laparoscopic technique.Body mass index was bigger in laparoscopic group(30.3±4.6 vs. 34.4±6.3, p=0.041). Hernia size andoperation time was not different between groups(7.6±4.8 cm vs. 8.9±3.1 cm, p=0.404) and [100(40-300)vs. 77.5(35-150) minutes, p=0.071), respectively. Lengthof stay was 2 days after both techniques.DISCUSSION and CONCLUSION: Laparoscopicincisional hernia repair has similar short term outcomeswith open technique.
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    Preliminary findings of our institute on initial staging of breast cancer with FDG-18 PET/CT
    (Springer, 2015) Çakır, Tansel; Abamor, Evrim; Çakır, Abdulvahit; Basım, Pelin; Gezen, Cem; Evren, Müjgan; Atasever, Tamer
    [Abstract Not Available]
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    Prognostic implications of response to neoadjuvant chemotherapy in breast cancer subtypes
    (Taylor and Francis Ltd., 2024) Yıldız, Anıl; Bilici, Ahmet; Açıkgöz, Özgür; Hamdard, Jamshid; Basım, Pelin; Çakır, Tansel; Çakır, Aslı; Ölmez, Ömer Fatih; Gezen, Cem; Yıldız, Özcan
    The current study was designed to assess the response to treatment, as well as clinical and survival outcomes, across different breast cancer subtypes in patients who underwent neoadjuvant chemotherapy (NAC). From 2014 to 2019, a total of 139 patients who were histologically confirmed to have breast cancer, underwent NAC, and subsequently received breast and axillary surgery, were retrospectively included in this study. The rates of pathological complete response (pCR) to NAC were significantly higher for HER2-positive and triple-negative subtypes than for luminal A and HER2-negative subtypes (p = 0.013). Multivariate analysis for disease-free survival (DFS) revealed that tumour grade and the presence of pCR were independent prognostic factors. The presence or absence of a pCR with NAC was an independent prognostic indicator in the multivariate analysis for overall survival (OS). Lastly, achieving a pCR was independently predicted by 18F-FDG PET/CT findings, the HER2-positive subtype, and the triple-negative subtype. Despite the inherent methodological limitations, our findings underscore the significance of identifying predictive markers to tailor NAC plans, with the aim of improving survival outcomes.
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    The feasibility of hepatic resections using a bipolar radiofrequency device (Habib®)
    (Springer, 2015) Civil, Osman; Kement, Metin; Okkabaz, Nuri; Haksal, Mustafa; Gezen, Cem; Öncel, Mustafa
    The bipolar radiofrequency device (HabibA (R)) has been recently introduced in order to reduce intraoperative bleeding for a safe hepatic resection as an alternative to the conventional tools. However, indications, perioperative findings, and outcome of the device for hepatic resections remain and deserve to be analyzed. The current study aims to analyze the feasibility of the bipolar radiofrequency device (HabibA (R)) for hepatic resections. Information of the patients that underwent hepatic resection using with the HabibA (R) device between 2007 and 2011 was abstracted. Patient, disease, and operation-related findings and perioperative data were investigated. A total of 71 cases (38 [53.5 %] males, mean age was 56.8 A +/- 11.9) were analyzed. Metastatic disease (n = 55; 77.5 %) was the leading indication followed by primary liver and biliary malignancies (n = 7; 9.9 %), hemangioma (n = 5; 7 %), hydatid disease (n = 3; 2.8 %), and hepatic gunshot trauma (n = 1; 1.4 %). Metastasectomy was the most commonly performed procedure (n = 31; 56.3 %), but in 24 (77.4 %) cases, it was performed in addition to extended resections. Other procedures in the study patients include segmentectomy in 17, bisegmentectomy in 19, trisegmentectomy in 17, right or left hepatectomy in 8, and extended right/left hepatectomy in 3. The mean (+/- SD) operation time was 241.7 +/- 78.2 min. The median amount of bleeding was 300 cc (range 25-2500), and 23 (32.4 %) cases required perioperative transfusion. The median hospitalization period was 5 days (range 1-47). Lengthened drainage (n = 9, 12.7 %) and intraabdominal abscess (n = 8, 11.23 %) were the most common problems. Hepatic resections using the HabibA (R) device seem to be feasible in cases with primary and metastatic hepatic lesions and benign liver masses and even those with hepatic trauma. It may lessen the amount of intraoperative hemorrhage, although lengthened drainage and intraabdominal abscess were the major postoperative problems in these cases.