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    Abnormalities of cortical sources of resting state alpha electroencephalographic rhythms are related to education attainment in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment
    (NLM (Medline), 2021) Babiloni, Claudio C.; Ferri, Raffaele; Noce, Giuseppe; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Panzavolta, Andrea; Soricelli, Andrea; Nobili, Flavio Mariano; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Aktürk, Tuba; Hano?lu, Lütfü; Yener, Görsev G.; Özbek, Yağmur; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Glovannl B.; del Percio, Claudio
    In normal old (Nold) and Alzheimer's disease (AD) persons, a high cognitive reserve (CR) makes them more resistant and resilient to brain neuropathology and neurodegeneration. Here, we tested whether these effects may affect neurophysiological oscillatory mechanisms generating dominant resting state electroencephalographic (rsEEG) alpha rhythms in Nold and patients with mild cognitive impairment (MCI) due to AD (ADMCI). Data in 60 Nold and 70 ADMCI participants, stratified in higher (Edu+) and lower (Edu-) educational attainment subgroups, were available in an Italian-Turkish archive. The subgroups were matched for age, gender, and education. RsEEG cortical sources were estimated by eLORETA freeware. As compared to the Nold-Edu- subgroup, the Nold-Edu+ subgroup showed greater alpha source activations topographically widespread. On the contrary, in relation to the ADMCI-Edu- subgroup, the ADMCI-Edu+ subgroup displayed lower alpha source activations topographically widespread. Furthermore, the 2 ADMCI subgroups had matched cerebrospinal AD diagnostic biomarkers, brain gray-white matter measures, and neuropsychological scores. The current findings suggest that a high CR may be related to changes in rsEEG alpha rhythms in Nold and ADMCI persons. These changes may underlie neuroprotective effects in Nold seniors and subtend functional compensatory mechanisms unrelated to brain structure alterations in ADMCI patients.
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    Corrigendum to ‘‘Functional cortical source connectivity of resting stateelectroencephalographic alpha rhythms shows similar abnormalitiesin patients with mild cognitive impairment due to Alzheimer’s and Parkinson’s diseases” [Clin. Neurophysiol. 129 (2018) 766–782]
    (Elsevier Ireland Ltd., 2019) Babiloni, Claudio; Percio, Claudio Del; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, Maria Teresa; Catania, Valentina; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Bonanni, Laura; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Garn, Heinrich; Fraioli, Lucia; Pievani, Michela; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lütfü; Başar, Erol; Yener, Görsev; Emek-Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John Paul; De Pandis, Maria Francesca; Vacca, Laura; Stocchi, Fabrizio
    Objective: This study tested the hypothesis that markers of functional cortical source connectivity of resting state eyes-closed electroencephalographic (rsEEG) rhythms may be abnormal in subjects with mild cognitive impairment due to Alzheimer’s (ADMCI) and Parkinson’s (PDMCI) diseases compared to healthy elderly subjects (Nold). Methods: rsEEG data had been collected in ADMCI, PDMCI, and Nold subjects (N?=?75 for any group). eLORETA freeware estimated functional lagged linear connectivity (LLC) from rsEEG cortical sources. Area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification of Nold and MCI individuals. Results: Posterior interhemispheric and widespread intrahemispheric alpha LLC solutions were abnormally lower in both MCI groups compared to the Nold group. At the individual level, AUROC curves of LLC solutions in posterior alpha sources exhibited moderate accuracies (0.70–0.72) in the discrimination of Nold vs. ADMCI-PDMCI individuals. No differences in the LLC solutions were found between the two MCI groups. Conclusions: These findings unveil similar abnormalities in functional cortical connectivity estimated in widespread alpha sources in ADMCI and PDMCI. This was true at both group and individual levels. Significance: The similar abnormality of alpha source connectivity in ADMCI and PDMCI subjects might reflect common cholinergic impairment.
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    Reactivity of posterior cortical electroencephalographic alpha rhythms during eyes opening in cognitively intact older adults and patients with dementia due to Alzheimer's and Lewy body diseases
    (Elsevier Inc., 2022) Babiloni, Claudio; Lorenzo, Ivan; Lizio, Roberta; Lopez, Susanna; Tucci, Federico; Ferri, Raffaele; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Onofrj, Marco; Stocchi, Fabrizio; Vacca, Laura; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Aarsland, Dag; Parnetti, Lucilla; Marizzoni, Moira; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Hünerli Gündüz, Duygu; Taylor, John Paul; Schumacher, Julia; McKeith, Ian; Frisoni, Giovanni B.; De Pandis, Maria Francesca; Bonanni, Laura; Percio, Claudio Del; Noce, Giuseppe
    Please modify the Abstract as follows:Here we tested if the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms from the eye-closed to the eyes-open condition may differ in patients with dementia due to Lewy Bodies (DLB) and Alzheimer's disease (ADD) as a functional probe of the dominant neural synchronization mechanisms regulating the vigilance in posterior visual systems.We used clinical, demographical, and rsEEG datasets in 28 older adults (Healthy), 42 DLB, and 48 ADD participants. The eLORETA freeware was used to estimate cortical rsEEG sources.Results showed a substantial (> -10%) reduction in the posterior alpha activities during the eyes-open condition in 24 Healthy, 26 ADD, and 22 DLB subjects. There were lower reductions in the posterior alpha activities in the ADD and DLB groups than in the Healthy group. That reduction in the occipital region was lower in the DLB than in the ADD group.These results suggest that DLB patients may suffer from a greater alteration in the neural synchronization mechanisms regulating vigilance in occipital cortical systems compared to ADD patients.
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    Resting state alpha electroencephalographic rhythms are affected by sex in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment: A retrospective and exploratory study
    (Oxford University Press Inc, 2022) Babiloni, Claudio; Noce, Giuseppe; Ferri, Raffaele; Lizio, Roberta; Lopez, Susanna; Lorenzo, Ivan; Tucci, Federico; Soricelli, Andrea; Zurrón, Montserrat; Díaz, Fernando; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Cipollini, Virginia; Marizzoni, Moira; Güntekin, Bahar; Yıldırım, Ebru; Hanoğlu, Lütfü; Yener, Görsev; Hünerli Gündüz, Duygu; Onorati, Paolo; Stocchi, Fabrizio; Vacca, Laura; Maestú, Fernando; Frisoni, Giovanni B.; del Percio, Claudio
    In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (A beta 42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.
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    Resting state electroencephalographic alpha rhythms are sensitive to Alzheimer's disease mild cognitive impairment progression at a 6-month follow-up
    (2024) Babiloni, Claudio; Jakhar, Dharmendra; Tucci, Federico; Del Percio, Claudio; Lopez, Susanna; Soricelli, Andrea; Salvatore, Marco; Ferri, Raffaele; Catania, Valentina; Massa, Federico; Arnaldi, Dario; Famà, Francesco; Güntekin, Bahar; Yener, Görsev; Stocchi, Fabrizio; Vacca, Laura; Marizzoni, Moira; Giubilei, Franco; Yıldırım, Ebru; Hanoğlu, Lütfü; Hünerli, Duygu; Frisoni, Giovanni B.; Noce, Giuseppe
    Are posterior resting-state electroencephalographic (rsEEG) alpha rhythms sensitive to the Alzheimer's disease mild cognitive impairment (ADMCI) progression at a 6-month follow-up? Clinical, cerebrospinal, neuroimaging, and rsEEG datasets in 52 ADMCI and 60 Healthy old seniors (equivalent groups for demographic features) were available from an international archive (www.pdwaves.eu). The ADMCI patients were arbitrarily divided into two groups: REACTIVE and UNREACTIVE, based on the reduction (reactivity) in the posterior rsEEG alpha eLORETA source activities from the eyes-closed to eyes-open condition at ? ?10% and ?10%, respectively. 75% of the ADMCI patients were REACTIVE. Compared to the UNREACTIVE group, the REACTIVE group showed (1) less abnormal posterior rsEEG source activity during the eyes-closed condition and (2) a decrease in that activity at the 6-month follow-up. These effects could not be explained by neuroimaging and neuropsychological biomarkers of AD. Such a biomarker might reflect abnormalities in cortical arousal in quiet wakefulness to be used for clinical studies in ADMCI patients using 6-month follow-ups.
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    What a single electroencephalographic (EEG) channel can tell us about alzheimer's disease patients with mild cognitive impairment
    (NLM (Medline), 2023) del Percio, Claudio; Lopez, Susanna; Noce, Giuseppe; Lizio, Roberta; Tucci, Federico; Soricelli, Andrea; Ferri, Raffaele; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Marizzoni, Moira; Güntekin, Bahar; Yener, Görsev; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; Babiloni, Claudio
    Abnormalities in cortical sources of resting-state eyes closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10-20 montage) with 19 scalp electrodes characterized Alzheimer's disease (AD) from preclinical to dementia stages. An intriguing rsEEG application is the monitoring and evaluation of AD progression in large populations with few electrodes in low-cost devices. Here we evaluated whether the above-mentioned abnormalities can be observed from fewer scalp electrodes in patients with mild cognitive impairment due to AD (ADMCI). Clinical and rsEEG data acquired in hospital settings (10-20 montage) from 75 ADMCI participants and 70 age-, education-, and sex-matched normal elderly controls (Nold) were available in an Italian-Turkish archive (PDWAVES Consortium; www.pdwaves.eu). Standard spectral fast fourier transform (FFT) analysis of rsEEG data for individual delta, theta, and alpha frequency bands was computed from 6 monopolar scalp electrodes to derive bipolar C3-P3, C4-P4, P3-O1, and P4-O2 markers. The ADMCI group showed increased delta and decreased alpha power density at the C3-P3, C4-P4, P3-O1, and P4-O2 bipolar channels compared to the Nold group. Increased theta power density for ADMCI patients was observed only at the C3-P3 bipolar channel. Best classification accuracy between the ADMCI and Nold individuals reached 81% (area under the receiver operating characteristic curve) using Alpha2/Theta power density computed at the C3-P3 bipolar channel. Standard rsEEG power density computed from six posterior bipolar channels characterized ADMCI status. These results may pave the way toward diffuse clinical applications in health monitoring of dementia using low-cost EEG systems with a strict number of electrodes in lower- and middle-income countries.
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    What a single electroencephalographic (EEG) channel can tell us about patients with dementia due to Alzheimer's disease
    (Elsevier B.V., 2022) Del Percio, Claudio; Noce, Giuseppe; Lopez, Susanna; Tucci, Federico; Carlin, Graziano; Lizio, Roberta; Musat, Andreea M.; Soricelli, Andrea; Salvatore, Marco; Ferri, Raffaele; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Buttinelli, Carla; Giubilei, Franco; Marizzoni, Moira; Güntekin, Bahar; Yener, Görsev; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; Babiloni, Claudio
    Abnormalities in cortical sources of resting-state eyes-closed electroencephalographic (rsEEG) rhythms recorded by hospital settings (10–20 electrode montage) with 19 scalp electrodes provide useful markers of neurophysiological dysfunctions in the vigilance regulation in patients with Alzheimer's disease dementia (ADD). Here we tested whether these markers may be effective from a few scalp electrodes towards the use of low-cost recording devices. Clinical and rsEEG data acquired in hospital settings (10–20 electrode montage) from 88 ADD participants and 68 age-, education-, and sex-matched normal elderly controls (Nold) were available in an international Eurasian database. Standard spectral FFT analysis of rsEEG data for individual delta, theta, and alpha frequency bands was from C3-P3, C4-P4, P3-O1, and P4-O2 bipolar channels. As compared to the Nold group, the ADD group showed increased delta, theta, low-frequency alpha power density and decreased high-frequency alpha power density at all those bipolar channels. The highest classification accuracy between the ADD and Nold individuals reached 90 % (area under the receiver operating characteristic curve) using Alpha2/Theta power density computed at the C3-P3 bipolar channel. Standard rsEEG power density computed from a few posterior bipolar channels successfully classified Nold and ADD individuals, thus encouraging a massive prescreening of neurophysiological mechanisms underpinning the vigilance dysregulation in underserved old seniors.