Yazar "Ersen, Atilla" seçeneğine göre listele

Listeleniyor 1 - 5 / 5
  • Küçük Resim
    Öğe
    Assessment of retinal thickness as a marker of brain masculinization in children with congenital adrenal hyperplasia: A pilot study
    (De Gruyter, 2019) Önal, Hasan; Kutlu, Esra; Aydın, Banu; Ersen, Atilla; Topal, Neval; Adal, Erdal; Güneş, Hatice; Doktur, Hilal; Tanıdır, Canan; Pirhan, Dilara; Sayın, Nihat
    To investigate the relationship between brain masculinization and retinal thickness in children with congenital adrenal hyperplasia (CAH). Forty-five patients with CAH aged between 4 and 18 years and 30 age-matched healthy controls were included in this prospective study. Macular area was examined with optical coherence tomography (OCT); central subfield thickness (CST), cube volume (CV) and macular retinal thickness (MT) were measured in each subject. A gender identity questionnaire (GIQ) was used for the evaluation of gender happiness index. Girls with CAH had a higher CV (p = 0.002) and MT (p = 0.003) than healthy girls. No significant difference was found between boys with CAH and healthy boys regarding the retinal thickness measurements. Mean CST, CV and MT were significantly higher in boys than in girls in the control group (p = 0.013, p < 0.001, respectively), but there was no significant difference in those parameters between girls and boys with CAH. The gender happiness index was not different between healthy boys and boys with CAH, but was significantly lower in girls with CAH than healthy girls (p = 0.01). As retina is part of the brain, our finding appears to be a morphological evidence of the excess androgen exposure on brain structures in girls with CAH. In addition, we suggest using retinal thickness measurements as a marker of prenatal excess androgen exposure in future studies.
  • Küçük Resim Yok
    Öğe
    Evaluation of immunization status in patients with cerebral palsy: A multicenter CP-VACC study
    (Springer, 2022) Bozkaya Yılmaz, Sema; Karadağ Öncel, Eda; Olgaç Dündar, Nihal; Gençpınar, Pınar; Sarıoğlu, Berrak; Arıcan, Pınar; Ersen, Atilla; Yılmaz Çiftdoğan, Dilek; Yüksel, Merve Feyza; Bektaş, Ömer; Teber, Serap; Kılıç, Betül; Çalık, Mustafa; Karaca, Meryem; Canpolat, Mehmet; Kumandaş, Sefer; Per, Hüseyin; Gümüş, Hakan; Öztürk, Selcan; Okuyaz, Çetin; Kömür, Mustafa; İpek, Rojan; Özbudak, Pınar; Arhan, Ebru; İnce, Hülya; Gürbüz, Gürkan; Mert, Gülen Gül; Özcan, Neslihan; Ölmez Türker, Akgün; Gazeteci Tekin, Hande; Kırık, Serkan; Günbey, Ceren; Çarman, Kürşat Bora; Yarar, Coşkun; Çavuşoğlu, Dilek
    Children with chronic neurological diseases, including cerebral palsy (CP), are especially susceptible to vaccine-preventable infections and face an increased risk of severe respiratory infections and decompensation of their disease. This study aims to examine age-appropriate immunization status and related factors in the CP population of our country. This cross-sectional prospective multicentered survey study included 18 pediatric neurology clinics around Turkey, wherein outpatient children with CP were included in the study. Data on patient and CP characteristics, concomitant disorders, vaccination status included in the National Immunization Program (NIP), administration, and influenza vaccine recommendation were collected at a single visit. A total of 1194 patients were enrolled. Regarding immunization records, the most frequently administrated and schedule completed vaccines were BCG (90.8%), hepatitis B (88.9%), and oral poliovirus vaccine (88.5%). MMR was administered to 77.3%, and DTaP-IPV-HiB was administered to 60.5% of patients. For the pneumococcal vaccines, 54.1% of children received PCV in the scope of the NIP, and 15.2% of children were not fully vaccinated for their age. The influenza vaccine was administered only to 3.4% of the patients at any time and was never recommended to 1122 parents (93.9%). In the patients with severe (grades 4 and 5) motor dysfunction, the frequency of incomplete/none vaccination of hepatitis B, BCG, DTaP-IPV-HiB, OPV, and MMR was statistically more common than mild to moderate (grades 1-3) motor dysfunction (p = 0.003, p < 0.001, p < 0.001, p < 0.00, and p < 0.001, respectively). Physicians' influenza vaccine recommendation was higher in the severe motor dysfunction group, and the difference was statistically significant (p = 0.029). Conclusion: Children with CP had lower immunization rates and incomplete immunization programs. Clinicians must ensure children with CP receive the same preventative health measures as healthy children, including vaccines.
  • Küçük Resim Yok
    Öğe
    Possible effects of neonatal vitamin B12 status on TSH-screening program: A cross-sectional study from Turkey
    (Walter de Gruyter GMBH, 2017) Önal, Zerrin; Balkaya, Seda; Ersen, Atilla; Mutlu, Neval; Önal, Hasan; Adal, Erdal
    Background: In this study we evaluated whether vitamin B12 deficiency affects neonatal screening (NS) for congenital hypothyroidism (CH). Methods: A cross-sectional study conducted from 2010 to 2011. A total of 10,740 infants were born in our hospital in this period. Thyroid-stimulating hormone (TSH) was tested for NS and neonates with abnormal screening results (TSH > 20 mIU/L) were re-examined. Two hundred and twenty-nine re-called subjects (re-call rate 2.3%) were compared to 77 randomly selected newborns with normal TSH screening among these term newborns in terms of serum TSH, free T4, vitamin B12 and homocysteine status. Results: Of the 229 re-called subjects, 11 infants with CH and 21 infants with transient TSH elevation were detected. In the normal TSH screening group, only two infants were diagnosed with transient TSH elevation. Mean serum B12 levels were 126.4 +/- 48.7 pg/mL and 211.9 +/- 127.9 pg/mL in the positive TSH-screening group and the control group, respectively. There was a significant difference between positive and normal TSH-screening groups in regard to serum TSH, free T4, serum B12 and homocysteine levels. Conclusions: We found a significant vitamin B12 deficiency in positive TSH-screening infants. Beside the crucial role of vitamin B12 in newborns, deficiency seems to increase the recall rates of infants in an NS program for CH.
  • Küçük Resim
    Öğe
    Recognizing the psychosocial aspects of type 1 diabetes in adolescents
    (Galenos Publishing, 2015) Adal, Erdal; Önal, Zerrin; Ersen, Atilla; Yalçın, Koray; Önal, Hasan; Önal, Hasan
    Objective: Considering the ever increasing population of diabetic adolescents and the association of the disease with psychosocial problems throughout its course, depression and/or anxiety and social support from parents are issues of special concern in these patients. The study aimed to identify the depression and anxiety state of diabetic adolescents and its impact on the management of diabetes mellitus (DM). Methods: 295 adolescents with type 1 DM and their parents attended our study. Psychological distress was assessed using the Children's Depression Inventory and the State-Trait Anxiety Inventory (STAI I-II) for Children, Perceived Social Support from Family (PSS-Fa) scale, Beck Depression Inventory for adults, STAI I-II for adults and the Multidimensional Scale of Perceived Social Support (MSPSS). Records of glycemic measurements, insulin dosage and hemoglobin A1c levels were used as glycemic control parameters. Results: Depression rate was 12.9%. State (p<0.001) and trait anxiety (p<0.001) levels were high; PSS-Fa (p<0.001) and MSPSS (p<0.006) scores were low in the depressive patients. Positive correlations were noted between depression, PSS-Fa, STAI-I and STAI-II. Conclusion: Therapeutic strategies of DM should include co-existing psychiatric conditions throughout the course of the disease. In diabetic adolescents, PSS-Fa, STAI-I and STAI-II appear to be effective tools in the evaluation of depression.
  • Küçük Resim Yok
    Öğe
    Seroprotection status of hepatitis B and measles vaccines in children with type 1 diabetes mellitus
    (Walter De Gruyter Gmbh, 2016) Önal, Zerrin; Ersen, Atilla; Bayramoğlu, Elvan; Kazancı Yaroğlu, Selcen; Önal, Hasan; Adal, Erdal
    Background: Type 1 diabetes mellitus (T1DM) is speculated to have an impaired immunological response to vaccines. This paper aimed to investigate the presence of specific antibodies against hepatitis B virus (HBV) and measles in diabetic children who had been immunized according to the standard national calendar of immunization. Methods: Two hundred and one diabetic children and 140 healthy controls were prospectively evaluated. Antibodies against hepatitis B (anti-HBs) and measles were detected in all individuals who completed the vaccination schedule. We noted onset of T1DM, duration of the disease, diabetes-related autoantibodies and mean HbA(1c) levels. Results: Some 72.6% of diabetics and 82.1% of controls had anti-HBs (+) (p=0.04). We found a reduced efficacy of measles vaccination in anti-HBs (-) diabetic children (p=0.009), even though there was no significant difference between the study and control groups. Onset of the disease was earlier in anti-HBs (-) diabetics than in controls (p=0.038). No difference with respect to other parameters was found. Conclusions: Our data showed a reduced seroprotection rate for HBV vaccination in diabetic children and for measles with anti-HBs (-) diabetics. Larger studies should be encouraged to confirm the vaccine efficacy in diabetic children and to elucidate possible pathogenic mechanisms.