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  • Küçük Resim
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    Do we know multifarious organ abnormalities of adults with Klippel-Feil syndrome?
    (Gulhane Medical School, University of Health Sciences, 2016) Çakmak, Selami; Mahiroğulları, Mahir; Uz, Ömer; Erkul, Evren; Keklikçi, Kenan; Rodop, Osman
    Klippel-Feil syndrome (KFS) is characterized by a classical triad (short neck, low posterior hair line, limitation of neck movements). Segmentation problems of cervical vertebra cause the main clinic in patients, and extraskeletal anomalies are also reported. The aim of this study is to review and emphasize common clinical findings of KFS patients. Between 2000 and 2011, 120 individuals with facial asymmetry and short neck were evaluated. Forty-two adult patients with KFS were included in this study. Patients were assessed for associated skeletal and extraskeletal pathologies. There were 41 male (98%) and 1 female (2%) individuals. Of forty-two patients, thirty-one (n=31; 74%) were classified as type I, nine (n=9; 21%) as type II, and two (n=2; 5%) as type III. Classical clinical triad was detected in all patients. Congenital scoliosis has been observed in all patients except one. Sprengel deformity was observed in 10 individuals (24%). Associated other system disorder ratios were 9.5% for urogenital problems, 23.8% for cardiovascular pathologies and 31% for audiological problems. Spinal and other multi-organ pathologies of patients with KFS may lead to serious problems which may eventually need medical treatment. Detailed assessment for possible systemic disorders and close follow-up may be helpful for KFS patients.
  • Küçük Resim
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    The protective effects of different treatments on rat salivary glands after radiotherapy
    (Springer, 2016) Konak, Murat; Cıncık, Hakan; Erkul, Evren; Küçükodacı, Zafer; Güngör, Atila; Özdemir, Sevim; Çekin, Engin; Arisan, Volkan; Mutluoğlu, Mesut; Salihoğlu, Murat
    This study was aimed to evaluate the efficacy of treatment modalities for minimizing salivary gland damage caused by radiotherapy. Forty rats were divided into five groups. Group 1 had no irradiation or any treatment. Group 2 underwent only 15 Gy single dose radiotherapy. N-acetylcysteine, dexamethasone, hyperbaric oxygen treatment were given, respectively to the group 3, 4 and 5 for 5 days. 15 Gy single dose radiotherapy was applied to the group 3, 4 and 5 on the second day. Pyknosis, lysis, and vacuolization were examined in ductal cells and pyknosis, lysis, vacuolization, inflammation and collective duct damage in acinar cells. Dexamethasone and hyperbaric oxygen did not prove to have a positive effect on acinar and ductal cell. N-acetylcysteine-applied group had statistically significantly lower amount of damage. We determined that the decrease of ductal and acinar cell damage in parotid glands of N-acetylcysteine-applied rats was more distinct and statistically.