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Öğe DNA methylation pattern of TM6SF2 influences NAFLD progression in genotype-dependent manner(Elsevier Science Bv, 2019) Ulukan, Burge; Yiğit, Buket; Yılmaz, Onur; Cömert, Melis Cansu; Erkan, Mert; Adalı, Gupse; Dayangaç, Murat; Zeybel, MüjdatBackground and aims: Non-alcoholic fatty liver disease (NAFLD) arises due to complex interaction of genetic and environmental factors. Evidence suggests that transmembrane 6 superfamily member 2 (TM6SF2) E167K variant is associated with NAFLD susceptibility and progression. The loss of function mutation in TM6SF2 plays a pivotal role in hepatic lipid accumulation, however, it remains unknown if there is an interplay between genetic and epigenetic mechanisms modifying disease pathogenesis. In this study, we aimed to investigate whether epigenetic marks of TM6SF2 could affect development of hepatic steatosis and fibrosis.Öğe Gallbladder polyps: Correlation of size and clinicopathologic characteristics based on updated definitions(Public Library of Science, 2020) Taşkın, Orhun C.; Baştürk, Olca; Reid, Michelle D.; Dursun, Nevra; Bağcı, Pelin; Saka, Burcu; Balcı, Serdar; Memiş, Bahar; Bellolio, Enrique; Araya, Juan Carlos; Roa, Juan Carlos; Tapia, Oscar; Losada, Hector; Sarmiento, Juan; Jang, Kee-Taek; Jang, Jin-Young; Pehlivanoğlu, Burçin; Erkan, Mert; Adsay, VolkanBackground Different perspectives exist regarding the clinicopathologic characteristics, biology and management of gallbladder polyps. Size is often used as the surrogate evidence of polyp behavior and size of >= 1cm is widely used as cholecystectomy indication. Most studies on this issue are based on the pathologic correlation of polyps clinically selected for resection, whereas, the data regarding the nature of polypoid lesions from pathology perspective -regardless of the cholecystectomy indication- is highly limited. Methods In this study, 4231 gallbladders -606 of which had gallbladder carcinoma- were reviewed carefully pathologically by the authors for polyps (defined as >= 2 mm). Separately, the cases that were diagnosed as "gallbladder polyps" in the surgical pathology databases were retrieved. Results 643 polyps identified accordingly were re-evaluated histopathologically. Mean age of all patients was 55 years (range: 20-94); mean polyp size was 9 mm. Among these 643 polyps, 223 (34.6%) were neoplastic: I. Non-neoplastic polyps (n = 420; 65.4%) were smaller (mean: 4.1 mm), occurred in younger patients (mean: 52 years). This group consisted of fibromyoglandular polyps (n = 196) per the updated classification, cholesterol polyps (n = 166), polypoid pyloric gland metaplasia (n = 41) and inflammatory polyps (n = 17). II. Neoplastic polyps were larger (mean: 21 mm), detected in older patients (mean: 61 years) and consisted of intra-cholecystic neoplasms (WHO's "adenomas" and "intracholecystic papillary neoplasms", >= 1 cm; n = 120), their "incipient" version (<1 cm) (n = 44), polypoid invasive carcinomas (n = 26) and non-neoplastic polyps with incidental dysplastic changes (n = 33). In terms of size cut-off correlations, overall, only 27% of polyps were >= 1 cm, 90% of which were neoplastic. All (except for one) >= 2 cm were neoplastic. However, 14% of polyps <1 cm were also neoplastic. Positive predictive value of >= 1 cm cut-off -which is widely used for cholecystectomy indication-, was 94.3% and negative predictive value was 85%. Conclusions Approximately a third of polypoid lesions in the cholecystectomies (regardless of the indication) prove to be neoplastic. The vast majority of (90%) of polyps >= 1 cm and virtually all of those >= 2 cm are neoplastic confirming the current impression that polyps >= 1 cm ought to be removed. However, this study also illustrates that 30% of the neoplastic polyps are <1 cm and therefore small polyps should also be closely watched, especially in older patients.Öğe Histopathologic infiltration pattern predicts metastasis and progression better than pT-stage and grade in well-differentiated pancreatic neuroendocrine tumors: A proposal for an infiltration-based morphologic grading system(Springer Nature, 2021) Taşkın, Orhun; Reid, Michelle; Bağcı Çulçi, Pelin; Balcı, Serdar; Armutlu, Ayşe; Demirtaş, Deniz; Pehlivanoğlu, Burçin; Saka, Burcu; Memiş, Bahar; Bozkurtlar, Emine; Leblebici, Can Berk; Corobea, Adelina Birceanu; Xue, Yue; Erkan, Mert; Kapran, Yersu; Sökmensüer, Cenk; Scarpa, Aldo; Luchini, Claudio; Baştürk, Olca; Adsay, Nazmi Volkan[Abstract Not Available]Öğe Histopathologic infiltration pattern predicts metastasis and progression better than pT-stage and grade in well-differentiated pancreatic neuroendocrine tumors: A proposal for an infiltration-based morphologic grading system(Springer Nature, 2021) Taşkın, Orhun; Reid, Michelle; Bağcı Çulçi, Pelin; Balcı, Serdar; Armutlu, Ayşe; Demirtaş, Deniz; Pehlivanoğlu, Burçin; Saka, Burcu; Memiş, Bahar; Bozkurtlar, Emine; Leblebici, Can Berk; Corobea, Adelina Birceanu; Xue, Yue; Erkan, Mert; Kapran, Yersu; Sökmensüer, Cenk; Scarpa, Aldo; Luchini, Claudio; Baştürk, Olca; Adsay, Nazmi Volkan[Abstract Not Available]Öğe Three-dimensional imaging of cleared human liver tissues reveals extensive fibrosis heterogeneity in non-alcoholic fatty liver disease(Elsevier, 2022) Yiğit, Buket; Özgönül, Ekin; Yaman, Ömer; Ulukan, Burge; Çetin Taş, Yağmur; Morova, Berna; Aydın, Musa; Uysallı, Yiğit; Demirtaş, Elif; Erkan, Mert; Gürsoy Özdemir, Yasemin; Karahüseyinoğlu, Serçin; Yurdaydın, Cihan; Akyıldız, Murat; Sheth, Abhishek; Kırımoğlu, Hale; Dayangaç, Murat; Ferhanoğlu, Onur; Kiraz, Alper; Zeybel, MüjdatBackground and aims: Liver fibrosis is a dynamic process of fibrogenesis and fibrolysis traditionally evaluated by liver biopsy. Accurate assessment of hepatic fibrosis is vital for optimal biomarker and drug development in the era of NASH clinical trials. The limitations of biopsy-based fibrosis staging include semi-quantitative assessment, sampling, and observer variability. In this study, we aimed to perform 3D imaging of optically transparent whole liver biopsy samples by light sheet fluorescence microscopy (LSFM) to quantify extra-cellular matrix proteins.Öğe Will the real "hepatobiliary cystadenocarcinoma" please stand up? True malignancy is exceedingly rare in cystic liver lesions; implications for pathologic evaluation and pre-operative decision making(Springer Nature, 2021) Armutlu, Ayşe; Quigley, Brian; Choi, Hegyong; Baştürk, Olca; Akkaş, Gizem; Pehlivanoğlu, Burçin; Memiş, Bahar; Jang, Keetaek; Erkan, Mert; Erkan, Burcu; Balcı, Serdar; Saka, Burcu; Bağcı Çulçi, Pelin; Farris, Alton Brad; Kooby, David; Martin, Diego; Kalb, Bobby; Maithel, Shishir; Sarmiento, Juan; Reid, Michelle; Adsay, Nazmi VolkanBackground: Concern for hepatic cysts being “hepatobiliary cystadenocarcinoma” along with the allegedly high frequency of its occurrence in the literature (up to 30% of the hepatic cysts) remains a major driver for the management of cystic lesions in this organ.Öğe Will the real "hepatobiliary cystadenocarcinoma" please stand up? True malignancy is exceedingly rare in cystic liver lesions; implications for pathologic evaluation and preoperative decision making(Springer Nature, 2021) Armutlu, Ayşe; Quigley, Brian; Choi, Hegyong; Baştürk, Olca; Akkaş, Gizem; Pehlivanoğlu, Burçin; Memiş, Bahar; Jang, Keetaek; Erkan, Mert; Erkan, Burcu; Balcı, Serdar; Saka, Burcu; Bağcı Çulçi, Pelin; Farris, Alton Brad; Kooby, David; Martin, Diego; Kalb, Bobby; Maithel, Shishir; Sarmiento, Juan; Reid, Michelle; Adsay, Nazmi Volkan[Abstract Not Available]
