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    Comparison of doppler ultrasonography and magnetic resonance imaging of fibroids
    (2022) Ergenekon, Pelin
    OBJECTIVE: This study aimed to compare Doppler ultrasonography (USG) and magnetic resonance imaging (MRI) in the evaluation of various characteristics of myomas, including size and growth.MATERIAL AND METHODS: This descriptive study was conducted on female patients admitted to a private gynecology clinic in Turkey. Doppler USG and MRI measurements of the patients were performed and the following indices were calculated: Diastolic average ratio (DAR), Systolic/diastolic ratio (SDR), End-diastolic velocity (EDV), Peak systolic velocity (PSV), Acceleration time (AT), Time-averaged mean velocity (Tmean), Impedance index (LML), Acceleration index (AI), Diastolic/systolic ratio (DSR), Resistivity index (RI), Pulsatility index (PI), Time-averaged maximum velocity (TAMX). These indices were evaluated in the whole study group and also among those older than 49 years.RESULTS: Doppler USG and MRI results of PSV, EDV, TAMX, Tort, PI, RI, SDR, AT, AI, DSR, LML, DAR indexes and tumor size change averages were found to be similar in both the study group and women older than 49 years. It was found that there were strong positive correlations between Doppler USG and MRI measurements of PSV, EDV, TAMX, Tort, PI, RI, SDR, AT, AI, DSR, LML, DAR indices and tumor size change among the women in the study group.CONCLUSIONS: The results found in the research revealed that Doppler USG is as convenient as MRI in the diagnosis of myomas.
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    Effect of HRT on serum lipid, apolipoprotein ai, apolipoprotein B, and lipoprotein (a) in postmenopausalwomen: Added benefits of dietary and exercise improvement
    (Ortadoğu Reklam Tanıtım Yayıncılık Turizm Eğitim İnşaat Sanayi ve Ticaret A.Ş., 2018) Ergenekon, Pelin
    Objective: In this quasi-experimental study, we aimed to measure the effect of hormone replacement therapy (HRT) on serum lipid, apolipoprotein AI, apolipoprotein B, and lipoprotein (a). The study had three objectives: to replicate previous studies' findings on the effect of HRT on lipid and lipoprotein profiles; to integrate possible effects of dietary and exercise improvements (considered as independent predictors), covariates, and interaction variables; and to report effect sizes capable of estimating the impact of HRT on each outcome variable of the study. Material and Methods: The effect of HRT on serum lipid, apolipoprotein AI, apolipoprotein B, and lipoprotein (a) was determined in a case group of 86 postmenopausal women compared with that in a control group of 97 age-matched women who were not receiving HRT and who were not menopausal. Results: HRT had the expected salutary effect on all measured variables, except for apolipoprotein AI. The largest effect size was observed for high-density lipoprotein cholesterol, suggesting the need for replication and if necessary, further investigation of why HRT might be particularly beneficial for highdensity lipoprotein cholesterol levels of postmenopausal women. Conclusion: Finally, the study found neither an independent nor interactive effect of diet or exercise on the effect of HRT.
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    Interleukin-6 levels in the cervicovaginal fluid of pregnant women and its predictive value in preterm delivery
    (Bagcilar Training and Research Hospital, 2020) Ergenekon, Pelin
    Objective: The aim of this study was to determine interleukin (IL)- 6 levels in the cervicovaginal fluid of pregnant women and its value in predicting preterm delivery. Method: One hundred and eleven pregnant women were retrospectively included in the study. Cervicovaginal secretions for each pregnant woman were obtained with a sterile Dacron swab for IL-6 detection. IL-6 was determined using an enzyme-linked immunosorbent assay method. Results: The mean IL-6 levels were found to be significantly higher in the preterm delivery group (5.84±2.09 pg/mL) than in the term delivery group (2.24±0.77 pg/mL) (p=0.001). Relationships were found between IL-6 levels and the frequency of intra-amniotic infection, preterm birth and the history of previous preterm birth. Conclusion: A strong association was found between increased cervicovaginal fluid IL-6 levels and preterm delivery. Results suggest that measurement of IL-6 levels from cervicovaginal swab samples during pregnancy can be used to identify patients with risk as a predictive biomarker for preterm birth.