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Öğe A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human(Public Library of Science, 2015) Kılıç, Ülkan; Gök, Özlem; Erenberk, Ufuk; Dündaröz, Mehmet Ruşen; Torun, Emel; Küçükardalı, Yaşar; Elibol, Birsen; Uysal, Ömer; Dündar, Tolga TuranAging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.Öğe Evaluation of cardiac arrhythmias by electrocardiographic markers in pediatric patients who have tuberous sclerosis without cardiac rhabdomyoma(Elsevier France-Editions Scientifiques Medicales Elsevier, 2021) Yozgat, Yasemin; Kuş, Hazar Doğuş; Kahraman, Fatma; Elagöz Yüksel, Mine; Fırat, Cem Koray; Toprak, Atakan; Yozgat, Can Yılmaz; Yakut, Kadriye; Sönmez Şahin, Şeyma; İşcan, Akın; Otçu Temur, Hafize; Ergör, Serap Nur; Erenberk, Ufuk; Sarıtaş, Tuba BerraBackground: Tuberous sclerosis (TS) is an autosomal dominant and hereditary disorder. Cardiac rhabdomyoma and arrhythmias are the most deleterious risk factors linked to TS. Although arrhythmias in pediatric patients with TS who have cardiac rhabdomyoma have been frequently reported, arrhythmia in patients who have TS without rhabdomyoma is rarely reported in the literature. The study aimed to assess the susceptibility of pediatric patients who have TS without cardiac rhabdomyoma to cardiac arrhythmia using electrocardiographic (ECG) markers. Methods: This prospective study included 10 patients who had TS without cardiac rhabdomyoma. The control group was made up of 30 healthy children of the same age and sex as the patient group. P wave, P wave dispersion, QT dispersion, QTc dispersion, TP-e interval, and TP-e interval dispersion were calculated on 12-lead surface ECGs for each patient in both groups and compared. Results: P wave, P wave dispersion, QT dispersion, and QTc dispersion were found to be significantly higher in the patient group (P<0.001). Furthermore, patients had a greater Tp-e interval and Tp-e interval dispersion than healthy children (P<0.001). Conclusion: Pediatric patients with TS without cardiac rhabdomyoma might be prone to atrial and ventricular arrhythmias according to their prolonged ECG markers. Our findings suggest that patients with TS without cardiac rhabdomyoma need close monitoring for atrial and ventricular arrhythmias.Öğe Rolle von parametern bei der vollblutanalyse als indikator für systemische entzündungen bei kindern mit rheumatischen klappenerkrankungen(2024) Nurmammadova, Lala; Yozgat, Yılmaz; Yozgat, Can Yılmaz; Babayeva, Türkay; Bayramova, Nigar; Talebazadeh, Faraz; Koç, Ertan; Ustabaş Kahraman, Feyza; Erenberk, UfukZusammenfassung Zweck: Die wichtigste Ursache für Mortalität und Morbidität bei akutem rheumatischem Fieber (ARF) sind Karditis und rheumatische Herzkrankheit (RHD). Ziel dieser Studie war es, Marker zu identifizieren, die bei Vollblutanalysen bei pädiatrischen Patienten mit RHD, die regelmäßig eine sekundäre Deposilin-Prophylaxe erhielten, Indikatoren für chronische Entzündungen sein können. Methoden: In unserer Studie wurden 100 Kinder mit ARF im Alter zwischen 4 und 18 Jahren in der pädiatrischen kardiologischen Ambulanz der Patientengruppe nachbeobachtet. Die Kontrollgruppe bestand aus 100 gesunden Kindern desselben Geschlechts und Alters wie die Patientengruppe. Alle Kinder in der Patientengruppe erhielten regelmäßig alle 21 Tage eine Deposilin-Prophylaxe. Unsere Studie umfasste viele Vollblutparameter, von denen in der Literatur berichtet wird, dass sie Veränderungen bei chronischen Entzündungskrankheiten darstellen. Diese Parameter waren CRP, RDW, PDW, MPV und Leukozytensubtypen, Neutrophilen-, Lymphozyten-, Monozytenzahlen und ihre Verhältnisse zueinander (Neutrophilen/Lymphozyten, Thrombozyten/Lymphozyten und Monozyten/Lymphozyten). Ergebnisse: Leukozytenzahl, Lymphozytenzahl, Basophilenzahl, MLR und Basophilenzahl waren in der Patientengruppe signifikant niedriger als in der Kontrollgruppe (p: 0,047, p: 0,023, p: 0,006). Darüber hinaus waren Eosinophilenzahl und RDW-Wert in der Patientengruppe signifikant höher als in der Kontrollgruppe (p: 0,043; p: 0,001). Schlussfolgerung: In unserer Studie wiesen niedrige Leukozyten-, Lymphozyten-, Basophilen-, MLR- und höhere Eosinophilenzahlen darauf hin, dass RDW als Marker für eine regelmäßige Depositilinprophylaxe bei pädiatrischen Patienten mit RHD wirksam eingesetzt werden könnte.Öğe Short-term azithromycin use is associated with QTc interval prolongation in children with cystic fibrosis(2024) Enhoş, Asım; Doğuş Kuş, Hazar; Yozgat, Can Yılmaz; Çakır, Erkan; Yazan, Hakan; Erol, Ahmet Berk; Erenberk, Ufuk; Yozgat, YılmazBackground: Azithromycin is used for children with cystic fibrosis (CF) for its immunomodulatory and antiinflammatory action. This study investigated the short-term alterations in QTc interval associated with azithromycin prophylaxis in pediatric patients with CF. Methods: This study included 121 patients with mild CF, of whom 76 received azithromycin (patient group) and 45 did not receive azithromycin (control group). The patient and control groups were categorized according to age as under 12 years of age and over 12 years of age. The first presentation measured all the patient and control groups at basic QTc time intervals. The QTc intervals of all patients were then remeasured systemically at 1, 3, and 6 months. Age categories and QTc intervals that were calculated at each month in the patient and control groups were compared statistically. Results: A statistically significant difference was detected in the patient group between the initial QTc interval time and the electrocardiogram (ECG) findings in the first and third months after prophylaxis treatment (p < 0.001; p = 0.01). However, no statistically significant difference was detected in the sixth month (p > 0.05) in all groups. Almost all of the children's QTc intervals were within normal range and within the safety zone (under 0.44 s). No statistically significant difference was detected in the control group between the initial ECG and the QTc intervals measured at 1, 3, and 6 months. Conclusion: Short-term use of azithromycin prophylaxis in pediatric patients with mild CF slightly increased the QTc interval in the first and third months of follow-up. Nevertheless, all QTc interval changes fell within the safety zone. Notably, 1 month of follow-up treatment should be performed to check for any alteration in the QTc interval. If increased QTc interval duration is not detected in the first month, azithromycin prophylaxis can be safely prescribed.Öğe Short-term efficacy of ORS formulation and propranolol regimen in children with POTS(Elsevier, 2020) Yozgat, Yılmaz; Otcu Temur, Hafize; Çoban, Şenay; Öner, Taliha; Karaarslan, Utku; Yozgat, Can Yılmaz; Karadeniz, Cem; Ergör, Serap Nur; Erenberk, UfukBackground: To evaluate the short-term effectiveness of reduced-osmolarity oral rehydration salt formulation (ORS) and propranolol in children diagnosed with postural orthostatic tachycardia syndrome (POTS) in head-up tilt testing (HUTT).Methods: Children were admitted with symptoms of orthostatic intolerance (OI) occurring in a standing position and disappearing in the supine position. Patients with heart rate increments of >= 40 bpm and symptoms of OI constituted the pediatric POTS group in HUTT. A total of 70 pediatric patients with POTS were included in the study. POTS patients were divided into two groups based on whether they were prescribed reduced-osmolarity ORS and propranolol or not. The study group comprised patients on a regimen of reduced-osmolarity ORS and propranolol (n = 34), while the control group comprised patients who were not prescribed any medication (n = 36). The frequency of symptoms and standardized symptom scores were analyzed before and after 3 months of treatment in both groups.Results: The post-treatment frequency of syncopal attacks was significantly reduced in both groups (P < 0.01 for both groups), but the post-treatment standardized symptom scores were significantly reduced in the pediatric study group compared with the control group (P < 0.01).Conclusion: The frequency of syncopal attacks was significantly reduced and the symptom scores for OI were improved in the study group. The improvement in OI symptom scores was better in the treatment group than in the control group. The control group symptoms persisted and caused extreme difficulty in their daily activities. In view of its clinical efficacy, we strongly advocate the use of combined treatment of reduced-osmolarity ORS and low-dose propranolol in pediatric patients with POTS. (C) 2020 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.Öğe SIRT1 gene variants are related to risk of childhood obesity(Springer, 2015) Kılıç, Ülkan; Gök, Özlem; Elibol, Birsen; Özgen, İlker Tolga; Erenberk, Ufuk; Uysal, Ömer; Dündaröz, Mehmet RuşenObesity is a multifactorial disorder resulting from the interaction between genetic, psychological, physical, environmental, and socioeconomic factors. SIRT1 gene has important effects on the regulation of adiponectin, caloric restriction, insulin sensitivity, coronary atherosclerosis, and cardiovascular diseases. The aim of this study was to investigate the association between childhood obesity and SIRT1 gene polymorphisms regarding rs7895833 A > G in the promoter region, rs7069102 C > G in intron 4, and rs2273773 C > T in exon 5 using PCR-CTPP method in 120 obese and 120 normal weight children. In this study, BMI, systolic and diastolic blood pressure, LDL cholesterol, triglyceride, and insulin levels were significantly higher and HDL-cholesterol levels were significantly lower in obese children compared to normal weight children. For rs7895833 A > G, the rate of having AG genotype and G allele was significantly higher in obese children compared to non-obese group (p < 0.001). The risk for obesity was increased by 1.9 times in G allele carriers; therefore, A allele may be protective against obesity. Both study groups had CT heterozygote genotype for rs2273773 C > T. There was no significant difference for rs7069102 C > G gene polymorphism between groups. Conclusion: This is the first study reporting an association between SIRT1 gene polymorphisms and obesity in children.
