Yazar "Eren, Necmi" seçeneğine göre listele
Listeleniyor 1 - 13 / 13
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Characteristics of primary glomerular disease patients with hematuria in Turkey: The data from TSN-Gold working group(Oxford University Press, 2020) Şumnu, Abdullah; Türkmen, Kültigin; Cebeci, Egemen; Türkmen, Aydın; Eren, Necmi; Seyahi, Nurhan; Oruç, Ayşegül; Dede, Fatih; Derici, Ülver; Baştürk, Taner; Şahin, Garip; Sipahioğlu, Murat; Manga Şahin, Gülizar; Tatar, Erhan; Dursun, Belda; Sipahi, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Memnune Sena; Güngör, Özkan; Kutlay, Sim; Bicik Bahçebaşı, Zerrin; Şahin, İdris; Kurultak, İlhan; Sevinç, Can; Yılmaz, Zülfikar; Turan Kazancıoğlu, Rümeyza; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Gül, Cuma Bülent; Altun, Bülent; Paydaş, Saime; Uzun, Sami; İstemihan, Zülal; Ergül, Metin; Dinçer, Mevlüt Tamer; Güllülü, Mustafa; Pişkinpaşa, Serhan Vahit; Akçay, Ömer Faruk; Ünsal, Abdulkadir; Koyuncu, Sümeyra; Gök, Mahmut; Öztürk, Savaş[Abstract Not Available]Öğe Characteristics of primary glomerular diseases patients with hematuria in Turkey: The data from TSN-GOLD Working Group(Springer, 2021) Şumnu, Abdullah; Türkmen, Kültigin; Cebeci, Egemen; Türkmen, Aydın; Eren, Necmi; Seyahi, Nurhan; Oruç, Ayşegül; Dede, Fatih; Derici, Ülver; Baştürk, Taner; Şahin, Garip; Sipahioğlu, Murat; Manga Şahin, Gülizar; Tatar, Erhan; Dursun, Belda; Sipahi, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Sena; Güngör, Özkan; Kutlay, Sim; Bicik Bahçebaşı, Zerrin; Şahin, İdris; Kurultak, İlhan; Sevinç, Can; Yılmaz, Zülfikar; Turan Kazancıoğlu, Rümeyza; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Gül, Bülent; Altun, Bülent; Paydaş, Saime; Uzun, Sami; İstemihan, Zulal; Ergül, Metin; Dinçer, Mevlüt Tamer; Güllülü, Mustafa; Pişkinpaşa, Serhan; Akçay, Ömer Faruk; Ünsal, Abdulkadir; Koyuncu, Sümeyra; Gök, Mahmut; Öztürk, SavaşPurpose Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. Methods Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. Results Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). Conclusion This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.Öğe Clinical and histopathological characteristics of primary focal segmental glomerulosclerosis in Turkish adults(Nature Research, 2024) Kurultak, İlhan; Güngör, Özkan; Öztürk, Savaş; Dirim, Ahmet Burak; Eren, Necmi; Yenigün, Ezgi; Dal, Elbis Ahbab; Dinçer, Mevlüt Tamer; Bora, Feyza; Akgür, Suat; Sumnu, Abdullah; Dursun, Belda; Sipahi, Savaş; Çetinkaya, Hakkı; Şahin, İdris; Şahin, Garip; Yılmaz, Mürvet; Vatansever, Bülent; Aydın, Emre; Ulu, Memnune Sena; Gündoğdu, Ali; Üstündağ, Sedat; Sayarlıoğlu, Hayriye; Kumru, Gizem; Elçioğlu, Ömer C.; Aydın, Zeki; Selçuk, Nedim Yılmaz; Önal Güçlü, Ceren; Oruç, Meriç; Küçük, Mehmet; Aktaş, Nimet; Derici, Ülver; Süleymanlar, GültekinThe data regarding primary FSGS (pFSGS) from different parts of the world differ. While the prevalence of pFSGS has been increasing in Western countries like the USA, it follows an inconsistent trend in Europe and Asia and a decreasing trend in Far Eastern countries such as China in the last two decades. There are undetermined factors to explain those national and geographic discrepancies. Herein, we aimed to reveal the current prevalence with clinical and histopathological characteristics of pFSGS in Turkish adults. This study includes the biopsy-proven pFSGS patients data recorded between 2009 and 2019, obtained from the national multicenter primary glomerulonephritis registry system of the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database. 850 of the 3875 primer glomerulonephritis patients(21.9%) have pFSGS. The mean age is 40.5 ± 14.2 and 435 (51.2%) of patients are male. Nephrotic syndrome is the most common biopsy indication (59.2%). 32.6% of patients have hematuria, 15.2% have leukocyturia and 7.8% have both. Serum creatinine, albumin, and proteinuria are 1.0 mg/dL (IQR = 0.7–1.4) mg/dl, 3.4 ± 0.9 g/dl, 3400 mg/day(IQR, 1774–5740), respectively. Females have lower mean arterial pressure (? 2.2 mmHg), higher eGFR (+ 10.0 mL/min/1.73 m2), and BMI (+ 1.6 kg/m2) than males. Thickened basal membrane(76.6%) and mesangial proliferation (53.5%) on light microscopy are the major findings after segmental sclerosis. IgM (32.7%) and C3 (32.9%) depositions are the most common findings on immunofluorescence microscopy. IgM positivity is related to lower eGFR, serum albumin, and higher proteinuria. The prevalence of pFSGS is stable although slightly increasing in Turkish adults. The characteristics of the patients are similar to those seen in Western countries.Öğe Clinical and pathologic features of primary membranous nephropathy in Turkey: A multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group(Taylor and Francis Ltd., 2022) Yıldız, Abdulmecit; Ulu, Sena; Oruç, Ayşegül; Uçar, Ali Rıza; Öztürk, Savaş; Alagöz, Selma; Eren, Necmi; Koçyiğit, İsmail; Köksal Cevher, Simal; Haras, Ali Burak; Şumnu, Abdullah; Arınsoy, Turgay; Şahin, Garip; Süleymanlar, Gültekin; Çavdar, Caner; Kumru Şahin, Gizem; Kurultak, İlhan; Ünsal, Abdulkadir; Şahin, Gülizar; Kazan, Sinan; Tatar, Erhan; Dikeç, Mehmet; Dursun, Belda; Sayarlıoğlu, Hayriye; Türkmen, Kultigin; Artan, Ayşe Serra; Aktaş, Nimet; Yılmaz, Zülfikar; Behlül, Ahmet; Dheir, Hamad; Kutlay, Sim; Seyahi, NurhanBackground: We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people. Methods: This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed. Results: A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 ± 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m2 (IQR, 75.4–116.3), and median proteinuria was 6000 mg/d (IQR, 3656–9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed. Conclusions: Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people.Öğe Demographic and clinical characteristics of rapidly progressive glomerulonephritis in Turkey(Oxford University Press, 2020) Aydın, Zeki; Türkmen, Kültigin; Dede, Fatih; Yaşar, Emre; Öztürk, Savaş; Aydın, Mehmet; Tatar, Erhan; Şahin, Garip; Manga Şahin, Gülizar; Oto, Özgür Akın; Şumnu, Abdullah; Eroğlu, Eray; Dinçer, Mevlüt Tamer; Dursun, Belda; Eren, Necmi; Sevinç, Mustafa; Güzel, Fatma Betül; Yalın, Serkan Feyyaz; Kutlay, Sim; Apaydın, Süheyla; Berktaş, Hacı Bayram; Kazan, Sinan; Dheir, Hamad; Bora, Feyza; Baştürk, Taner; Şahin, İdris[Abstract Not Available]Öğe Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group(Springer, 2021) Aydın, Zeki; Türkmen, Kültigin; Dede, Fatih; Yaşar, Emre; Öztürk, Savaş; Aydın, Mehmet; Tatar, Erhan; Şahin, Garip; Manga, Gülizar; Oto, Özgür; Şumnu, Abdullah; Eroğlu, Eray; Dinçer, Tamer; Dursun, Belda; Eren, Necmi; Sevinç, Mustafa; Güzel, Fatma Betül; Yalın, Serkan; Kutlay, Sim; Apaydın, Süheyla; Berktaş, Hacı Bayram; Kazan, Sinan; Dheir, Hamad; Bora, Feyza; Baştürk, Taner; Şahin, İdrisBackground In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune). Results Of 3875 patients, 200 patients with RPGN (mean age 47.9 +/- 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9-5.7) mg/dl, glomerular filtration rate was 18 (10-37) ml/min/1.73m(2)and proteinuria 2100 (1229-3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio. Conclusions Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.Öğe Epidemiological features of primary glomerular disease in Turkey: A multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group(BioMed Central Ltd, 2020) Türkmen, Aydın; Şumnu, Abdullah; Cebeci, Egemen; Yazıcı, Halil; Eren, Necmi; Seyahi, Nurhan; Dilek, Kamil; Dede, Fatih; Derici, Ülver; Ünsal, Abdulkadir; Şahin, Garip; Sipahioğlu, Murat; Gök, Mahmut; Tatar, Erhan; Dursun, Belda; Sipahi, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Sena; Güngör, Özkan; Kutlay, Sim; Bicik Bahçebaşı, Zerrin; Şahin, İdris; Kurultak, İlhan; Türkmen, Kültigin; Yılmaz, Zülfikar; Turan Kazancıoğlu, Rümeyza; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Duriye Deren; Gül, Cuma Bülent; Arıcı, Mustafa; Paydaş, Saime; Güven Taymez, Dilek; Küçük, Mehmet; Trablus, Sinan; Turgutalp, Kenan; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altıntepe, Lütfullah; Arıkan, İzzet Hakkı; Azak, Alper; Odabaş, Ali Rıza; Manga Şahin, Gülizar; Öztürk, SavaşBackground The largest data on the epidemiology of primary glomerular diseases (PGDs) are obtained from the databases of countries or centers. Here, we present the extended results of the Primary Glomerular Diseases Study of the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group. Methods Data of patients who underwent renal biopsy and received the diagnosis of PGD were recorded in the database prepared for the study. A total of 4399 patients from 47 centers were evaluated between May 2009 and May 2019. The data obtained at the time of kidney biopsy were analyzed. After the exclusion of patients without light microscopy and immunofluorescence microscopy findings, a total of 3875 patients were included in the study. Results The mean age was 41.5 +/- 14.9 years. 1690 patients were female (43.6%) and 2185 (56.3%) were male. Nephrotic syndrome was the most common biopsy indication (51.7%). This was followed by asymptomatic urinary abnormalities (18.3%) and nephritic syndrome (17.8%). The most common PGD was IgA nephropathy (25.7%) followed by membranous nephropathy (25.6%) and focal segmental glomerulosclerosis (21.9%). The mean total number of glomeruli per biopsy was 17 +/- 10. The mean baseline systolic blood pressure was 130 +/- 20 mmHg and diastolic blood pressure was 81 +/- 12 mmHg. The median proteinuria, serum creatinine, estimated GFR, and mean albumin values were 3300 (IQR: 1467-6307) mg/day, 1.0 (IQR: 0.7-1.6) mg/dL, 82.9 (IQR: 47.0-113.0) mL/min and 3.2 +/- 0.9 g/dL, respectively. Conclusions The distribution of PGDs in Turkey has become similar to that in other European countries. IgA nephropathy diagnosed via renal biopsy has become more prevalent compared to membranous nephropathy.Öğe Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group(2024) Oruç, Ayşegül; Türkmen, Aydın; Baştürk, Taner; Cebeci, Egemen; Turgutalp, Kenan; Çetinkaya, Hakkı; Üzerk Kibar, Müge; Seyahi, Nurhan; Tatar, Erhan; Ergül, Metin; Derici, Ülver; Aylı, Mehmet Deniz; Pınar, Musa; Bakar, Betül; Kazancıoğlu, Rümeyza; Yıldız, Abdülmecit; Dirim, Ahmet Burak; Yılmaz, Zülfükar; Türkmen, Kültigin; Tunca, Onur; Koç, Mehmet; Kutlay, Sim; Micozkadıoğlu, Hasan; Azak, Alper; Boztepe, Burcu; Üstündağ, Sedat; Şafak Öztürk, Seda; Ünsal, Abdulkadir; Karadağ, Serhat; Şahin, Gülizar; Coşgun Yenigün, Ezgi; Eren, Necmi; Güllülü, Mustafa; Gürsu, Meltem; Öztürk, Savaş; Şumnu, AbdullahBackground: Immunoglobulin A (IgA) nephropathy (IgAN) treatment consists of maximal supportive care and, for high-risk individuals, immunosuppressive treatment (IST). There are conflicting results regarding IST. Therefore, we aimed to investigate IST results among IgAN patients in Turkiye. Method: The data of 1656 IgAN patients in the Primary Glomerular Diseases Study of the Turkish Society of Nephrology Glomerular Diseases Study Group were analyzed. A total of 408 primary IgAN patients treated with IST (65.4% male, mean age 38.4 ± 12.5 years, follow-up 30 (3–218) months) were included and divided into two groups according to treatment protocols (isolated corticosteroid [CS] 70.6% and combined IST 29.4%). Treatment responses, associated factors were analyzed. Results: Remission (66.7% partial, 33.7% complete) was achieved in 74.7% of patients. Baseline systolic blood pressure, mean arterial pressure, and proteinuria levels were lower in responsives. Remission was achieved at significantly higher rates in the CS group (78% vs. 66.7%, p = 0.016). Partial remission was the prominent remission type. The remission rate was significantly higher among patients with segmental sclerosis compared to those without (60.4% vs. 49%, p = 0.047). In the multivariate analysis, MEST-C S1 (HR 1.43, 95% CI 1.08–1.89, p = 0.013), MEST-C T1 (HR 0.68, 95% CI 0.51–0.91, p = 0.008) and combined IST (HR 0.66, 95% CI 0.49–0.91, p = 0.009) were found to be significant regarding remission. Conclusion: CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.Öğe Membranous nephropathy in Turkey: Turkish society of nephrology glomeruler diseases (TSN-Gold) database results(Oxford University Press, 2020) Yıldız, Abdülmecit; Ulu, Memnune Sena; Oruç, Ayşegül; Uçar, Ali Rıza; Öztürk, Savaş; Alagöz, Selma; Eren, Necmi; Koçyiğit, İsmail; Köksal Cevher, Şimal; Haras, Ali Burak; Şumnu, Abdullah; Arınsoy, Turgay; Şahin, Garip; Süleymanlar, Gültekin; Çavdar, Caner; Şahin, Gizem Kumru; Kurultak, İlhan; Ünsal, Abdulkadir; Manga Şahin, Gülizar; Kazan, Sinan; Vatansever, Bülent; Dikeç, Mehmet; Dursun, Belda; Sayarlıoğlu, Hayriye; Türkmen, Kültigin; Artan, Ayşe Serra; Aktaş, Nimet; Yılmaz, Zülfikar; Behlül, Ahmet; Dheir, Hamad; Kutlay, Sim; Seyahi, Nurhan[Abstract Not Available]Öğe The importance of complement levels and clinical characteristics of primary membranoproliferative glomerulonephritis in Turkey(Oxford University Press, 2020) Tatar, Erhan; Oygar, Deren; Seyahi, Nurhan; Eren, Necmi; Cantürk, Yağmur; Güngör, Özkan; Derici, Ülver; Sipahioğlu, Murat; Yıldız, Abdülmecit; Karadağ, Serhat; Şumnu, Abdullah; Odabaş, Ali Rıza; Turgut, Didem; Çavdar, Caner; Şahin, Garip; Dursun, Belda; Güven Taymez, Dilek; Yılmaz Aydın, Fatma; Ulu, Memnune Sena; Baştürk, Taner; Yadigar, Serap; Bozacı, İlter; Behlül, Ahmet; Sipahi, Savaş; Bicik Bahçebaşı, Zerrin[Abstract Not Available]Öğe The prevalence, clinical and pathological characteristics of primary focal segmental glomerulosclerosis in Turkish adults: The data from TSN-Gold (Turkish society of nephrology glomerular diseases) working group(Oxford University Press, 2020) Kurultak, İlhan; Güngör, Özkan; Öztürk, Savaş; Dirim, Ahmet Burak; Eren, Necmi; Yenigün, Ezgi; Ahbap Dal, Elbis; Dinçer, Mevlüt Tamer; Bora, Feyza; Akgür, Suat; Şumnu, Abdullah; Dursun, Belda; Sipahi, Savaş; Çetinkaya, Hakkı; Şahin, İdris; Şahin, Garip; Yılmaz, Mürvet; Vatansever, Bülent; Aydın, Emre; Ulu, Memnune Sena; Gündoğan, Ali; Üstündağ, Sedat; Sayarlıoğlu, Hayriye; Şahin, Gizem Kumru; Elçioğlu, Ömer Celal; Aydın, Zeki; Selçuk, Nedim Yılmaz; Önal, Ceren; Oruç, Meriç; Küçük, Mehmet; Aktaş, Nimet; Derici, Ülver; Süleymanlar, Gültekin[Abstract Not Available]Öğe Trends of primary glomerular disease in Turkey from 2009 to 2017: A regional registry report from TSN-Gold working group(Oxford University Press, 2020) Gül, Cuma Bülent; Küçük, Mehmet; Öztürk, Savaş; Demir, Erol; Eren, Necmi; Şumnu, Abdullah; Seyahi, Nurhan; Güllülü, Mustafa; Dede, Fatih; Derici, Ülver; Koç, Yener; Şahin, Garip; Oymak, Oktay; Manga Şahin, Gülizar; Tatar, Erhan; Dursun, Belda; Dheir, Hamad; Apaydın, Süheyla; Süleymanlar, Gültekin; Ulu, Memnune Sena; Altunören, Orçun; Kutlay, Sim; Meşe, Meral; Şahin, İdris; Üstündağ, Sedat; Türkmen, Kültigin; Yılmaz, Mehmet Emin; Turan Kazancıoğlu, Rümeyza; Uzun, Özcan; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Aktaş, Nimet; Erdem, Yunus; Paydaş, Saime; Güven Taymez, Dilek; Can, Başak; Kıykım, Ahmet; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altıntepe, Lüftullah; Kaya, Burcu; Azak, Alper; Alışır Ecder, Sabahat; Çavdar, Caner; Selçuk, Nedim Yılmaz[Abstract Not Available]Öğe Trends of primary glomerular disease in Turkey: TSN-GOLD registry report(Springer, 2022) Gül, Cuma Bülent; Küçük, Mehmet; Öztürk, Savaş; Demir, Erol; Eren, Necmi; Şumnu, Abdullah; Seyahi, Nurhan; Güllülü, Mustafa; Dede, Fatih; Derici, Ülver; Koç, Yener; Şahin, Garip; Oymak, Oktay; Manga Şahin, Gülizar; Tatar, Erhan; Dursun, Belda; Dheir, Hamad; Apaydın, Süheyla; Süleymanlar, Gültekin; Ulu, Sena; Altınören, Orçun; Kutlay, Sim; Meşe, Meral; Şahin, İdris; Üstündağ, Sedat; Türkmen, Kültigin; Yılmaz, Mehmet Emin; Turan Kazancıoğlu, Rümeyza; Uzun, Özcan; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Aktaş, Nimet; Erdem, Yunus; Paydaş, Saime; Taymez, Dilek; Can, Başak; Kıykım, Ahmet; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altıntepe, Lütfullah; Kaya, Burcu; Azak, Alper; Alışır Ecder, Sebahat; Çavdar, Caner; Selçuk, Nedim YılmazBackground Although several renal biopsy registry reports have been published worldwide, there are no data on primary glomerular disease trends in Turkey. Methods Three thousand eight-hundred fifty-eight native kidney biopsy records were assessed in the Turkish Society of Nephrology Primary Glomerulopathy Working Group (TSN-GOLD) Registry. Secondary disease and transplant biopsies were not recorded in the registry. These records were divided into four periods, before 2009, 2009 to 2013, 2013-2017, and 2017-current. Results A total of 3858 patients (43.6% female, 6.8% elderly) were examined. Nephrotic syndrome was the most common biopsy indication in all periods (58.6%, 53%, 44.1%, 51.6%, respectively). In the whole cohort, IgA nephropathy (IgAN) (25.7%) was the most common PGN with male predominance (62.7%), and IgAN frequency steadily increased through the periods (x 2 = 198, p < 0.001). MGN was the most common nephropathy in the elderly (> 65 years), and there was no trend in this age group. An increasing trend was seen in the frequency of overweight patients (x 2 = 37, p < 0.0001). Although the biopsy rate performed with interventional radiology gradually increased, the mean glomeruli count in the samples did not change over the periods. Conclusions In Turkey, IgAN is the most common primary glomerulonephritis, and the frequency of this is increasing.
