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  • Küçük Resim
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    Effects of systemic erythropoietin treatment and heterogeneous xenograft in combination on bone regeneration of a critical-size defect in an experimental model
    (Churchill Livingstone, 2018) Diker, Nurettin Yağmur; Sarıcan, Hande; Cumbul, Alev; Kılıç, Ertuğrul
    The aim of the present study was to evaluate the effects of systemic EPO treatment alone or in combination with xenogenic bone graft augmentation on bone regeneration. Eleven adult male Sprague-Dawley rats were used in the present study. Rats were subjected to bilateral 5 mm critical size bone defects on the parietal bones under general anaesthesia. Right parietal bone defects were augmented with xenogenic bone graft and left parietal bone defect was left empty. Rats were randomly assigned for one of the two groups. One group of rats received (i) vehicle (n = 6) and other group received (ii) EPO (500IU kg/day) (n = 5). EPO treatment was continued for 28 days. Vascularization was analysed by immunohistochemical staining of CD31 (PECAM-1) and new bone formation was histomorphometrically evaluated. Xenogenic graft augmentation enhanced bone formation and vascularization significantly in either vehicle or EPO treated groups (p <0.05). Histomorphometric results of angiogenesis was similar in the EPO treated group and the control group. However, angiogenesis was significantly higher in the combination of systemic EPO treatment with graft augmentation than graft augmentation alone (p <0.01). Graft augmentation for treatment of critical size bone defects seems essential for proper bone healing. Results of the present study suggest that EPO potentiates the regenerative processes of augmented bone defects.
  • Küçük Resim
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    Evaluation of light-emitting diode photobiomodulation on bone healing of rat calvarial defects
    (Taylor & Francis, 2015) Deniz, Ediz; Arslan, Ahmet Hamdi; Diker, Nurettin Yağmur; Olgaç, Vakur; Kılıç, Ertuğrul
    One of the major problems in modern dentistry is the recovery of bone defects. The aim of this prospective experimental study was to evaluate the effect of light-emitting diode (LED) photobiomodulation therapy on bone healing of rat calvarial defects. Twenty-eight male Sprague Dawley rats were used for the study. Critical size defects with 5 mm diameter were made with a trephine bur used in a low-speed handpiece under continuous sterile saline irrigation on each side of the sagittal suture. All critical size defects on the right side were filled with corticocancellous bone graft material and all the defects on the left side were left empty. The animals were randomly divided into two groups of 14 rats each. Group I received LED therapy and Group II did not receive any therapy. OsseoPulse® LED device (Biolux Research Ltd.) 618 nm wavelength and 20 mW/cm2 output power irradiation was started immediately after the surgery and was applied for 20 minutes at 24-h intervals for 7 and 14 days. In each group, seven rats were sacrificed on the 8th day and the remaining rats were sacrificed on the 15th day. Bone healing of the non-grafted side was statistically significant in Group I on both 8th day and 15th day; on the other hand, in the grafted side, enhanced bone healing was dominantly observed on the 15th day in Group I, compared to Group II, although the difference was not significant. Within the limits of this study, the findings suggested that LED therapy might have a favourable effect in the early phase of bone healing.