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Öğe Alveol kret yetersizliğinin extraoral otojen onley kemik greftleri ile ogmentasyonda tünel ve krestal isizyon tekniklerinin karşılaştırılması(Yeditepe Üniversitesi, 2019) Develi, Tuba; Süzen, Muazzez; Altıparmak, Nur; Özel, Abdullah; Uçkan, SinaAmaç: Bu çalışmanın amacı alveoler kret yetersizliğinde krestal ve tünel olmak üzere 2 farklı insizyon tekniği kullanılarak ekstraoral donör sahadan alınan otojen kemik greftin yerleştirilmesinden sonra meydana gelen alıcı bölgedeki komplikasyonların karşılaştırılması ve değerlendirilmesidir. Gereç ve Yöntem: Bu çalışmada 13 hastadaki iliak greft ile ogmente edilen 14 krestal, 27 tünel yöntemi olmak üzere 41 bölgedeki minör (greftte minör açılma, vida başının açılması, sütur açılması, geçici parestezi, ılımlı ve/veya orta şiddette enfeksiyon) ve majör (greft kaybına neden olan enfeksiyon, majör açıklık, kalıcı parestezi) komplikasyonlar retrospektif olarak değerlendirilmiş ve iki farklı insizyon tekniği karşılaştırılmıştır. Ayrıca donör saha morbiditeleri değerlendirilmiştir. Bulgular: Tünel insizyon tekniği kullanılan grupta minor komplikasyon oranı %29.6 iken majör komplikasyon görülmemiştir. Krestal insizyon yapılan grupta % 50 minör komplikasyon ve %28.6 majör komplikasyon görülmüştür. İki farklı insizyon tekniği kullanılan gruplar arasında minör ve majör komplikasyon oranlarında istatistiksel olarak anlamlı fark bulunmuştur. İlaveten krestal teknikte ogmente edilen bölge sayısı ile minör komplikasyon oluşma riski insidansı arasında anlamlı ters korelasyon görülmüştür. Sonuç: Ekstraoral otojen greftlerde subperiosteal tünel yaklaşımı krestal yaklaşıma göre alıcı saha komplikasyon oranı dikkate alındığında daha başarılı ve alternatif bir yöntem olabilir.Öğe Closure of a persistant oroantral fistula with nasoseptal cartilage as a complication of lateral sinus lifting: A case report(2017) Gürler, Gökhan; Dilaver, Emrah; Soylu, Erkan; Develi, Tuba; Delilbaşı Barış ÇağrıOroantral fistula may develop due to tooth extraction, infection or surgical interventions in the posterior maxilla. Several surgical techniques have been described for oroantral fistula closure. All these techniques have different advantages and disadvantages. This report presents an oroantral fistula case, which occurred, following lateral sinus lifting procedure. Traditional surgical techniques (buccal advancement flap, palatal flap, and Bichat's buccal fat pad) were performed to close the oroantral fistula, but could not to be managed. Finally, closure was succeeded with septal cartilage graft placed over the bony defect.Öğe Intraartiküler botulinum toksin-a enjeksiyonunun temporomandibular eklem düzensizliklerine bağlı semptomlar üzerine etkisi(İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019) Sarı, Bilal Cemşit; Develi, TubaBu çalışmanın amacı klinikte redüksiyonsuz disk deplasmanı teşhisi konulan, ağrı, ağız açıklığında kısıtlılık şikayeti olan hastalara yapılan artrosentez ve sonrasında uygulanan eklem içi botulinum toksin –A (Btx-A)'nın semptomlar üzerindeki etkisinin retrospektif olarak incelenmesidir. Eklem içi Btx-A enjeksiyonunun çeşitli ortopedi çalışmalarında güvenilir şekilde kullanılmasına rağmen temporomandibular eklem üzerinde yapılan kapsamlı bir değerlendirmeye rastlanmamıştır. Mevcut çalışma 2016-2018 yılları arasında İstanbul Medipol Üniversitesi Diş Hekimliği Fakültesi Ağız Diş ve Çene Cerrahisi Ana Bilim Dalı'nda tedavi edilen hastaların kayıtları incelenerek yapılmıştır. Artrosentez endikasyonu konan hastalardan 30 hastanın 15'i artrosentez sonrası Btx-A enjeksiyonu (Grup I), 15'i ise sadece artrosentez (Grup II) yapılan hastalardan oluşmaktadır. Tedavi öncesi ve sonrası alınan kayıtlarda demografik veriler, VAS, ağız açıklığındaki değişimler karşılaştırılmıştır. İşlem öncesi ve işlemden sonra 1.hafta, 2.hafta, 3.hafta, 4.hafta, 3.ay ve 6.ayda hastalardan ağrılarını değerlendirmeleri istemiştir. Aynı zamanda ağız açıklığı değerlendirilmiş ve işlem öncesi ve 6.ayda RDC/TMD formu doldurmaları istenmiştir. Sonuç olarak; olguların 25'i kadın 5 'i erkek olup bu durum literatürle benzerlik göstermektedir. VAS değerlerinde 2.haftadan itibaren grup I'de grup II'ye göre istatistiksel olarak anlamlı derecede fark olduğu görülmüştür (p<0.05). Ağız açıklığının da her iki grupta arttığı ancak yine grup I 'de grup II'ye göre istatistiksel olarak anlamlı derecede daha fazla arttığı görülmüştür(p<0.05). Bu çalışma ile temporomandibular eklem internal düzensizliğinde minimal invaziv bir yöntem olarak uzun senelerdir güvenle uygulanmakta olan artrosentezin, ağrı azaltma etkisinin Btx-A ile potansiyelize edilebileceği, her iki yöntemin birlikte uygulanmasının tedavi başarısını arttıracağı sonucuna varılmıştır.Öğe Long-term effects of botulinum toxin a injection on pain and quality of life in patients with myofascial pain of masticatory muscles: A retrospective study(Termedia Publishing House Ltd., 2022) Develi, Tuba; Uzel, Tansu; Cesur, Emre; Uçkan, SinaIntroduction: Favorable effects of botulinum toxin type A (BoNT/A) on muscle hyperactivity and pain has led to its' use in the treatment of temporomandibular joint disorders, related to muscle pain and masticatory myofascial pain. Objectives: The aim of this retrospective study was to evaluate the short- and long-term effects of trigger point injections of BoNT/A in patients with myofascial pain syndrome. Material and Methods: The study included 17 individuals aged 19-57 years (mean, 33 years), with 2 years of follow-up records. Visual analogue scale (VAS), pressure-pain threshold (PPT), and maximum mouth opening (MMO) were applied to evaluate pain and dysfunction. Mood and sleep quality were assessed using Beck's depression inventory (BDI) and Pittsburgh sleep quality index (PSQI). All evaluations were repeated before (T0) as well as at 4 weeks (T1), 6 months (T2), and 2 years (T3) after BoNT/A injection. Results: VAS score was lower at all 3 post-injection time points compared to T0 (p < 0.001). Significant increases in PPT and MMO measurements were also observed at T1, T2, and T3 compared to T0. BDI scores were significantly reduced at T1 and T2 compared to T0 (p < 0.05). PSQI decreased significantly between T0 and T1 (p < 0.001), but increased at T3 (p < 0.05). Conclusions: BoNT/A injections are an effective treatment alternative that relieve myofascial pain and mouth opening restriction, and subsequently improve quality of life in both the short- and long-term.Öğe Periodontal disease and associated factors in patients with rheumatoid arthritis(Kare Yayıncılık, 2020) Tolu, Sena; Öztürk, Delal; Üşen, Ahmet; Rezvani, Aylin; Develi, TubaIntroduction: Periodontitis (PD) and rheumatoid arthritis (RA) are chronic inflammatory diseases that share complex multi-factorial pathologic processes, including genetics, environmental and inflammatory factors. This study aims to evaluate the periodontal status and its association with sociodemographic and clinical factors in patients with RA.Methods: This study included 51 patients with RA; the mean age was 49.75±9.79 years old and 10.59±6.37 years of disease duration. Sociodemographic data and the rheumatologic assessment included detailed profiling of the disease and serol-ogy were noted. A full mouth periodontal examination, including the Gingival index, Plaque index, Pocket probing depth and clinical attachment level, was carried out by a periodontist. The periodontal status was classified according to the Cen-ters for Disease Control-American Academy of Periodontology clinical case definitions.Results: Forty-five patients (88.2%) were female. 37.3% of patients had DAS28>3.2. All patients had PD, in mild (54.9%) to moderate (45.1%) severity. Aging, impaired oral hygiene, smoking, secondary Sjögren’s syndrome and high disease activity were associated with moderate PD.Discussion and Conclusion: This study results identified a serious need to pay particular attention to oral health in patients with RA and refer these patients for periodontal evaluation and treatment. Future studies are needed to better investigate whether if efforts to prevent periodontal disease may also help prevent RA.Öğe Prevalence of postoperative secondary bleeding and its relationship with intraoperative massive bleeding in patients undergoing orthognathic surgery(Elsevier, 2021) Süzen, Muazzez; Develi, Tuba; Uçkan, SinaIntroduction: Postoperative bleeding after orthognathic surgery is a rare but life-threatening complication. Maxillary surgery is the main cause of bleeding, after which excessive epistaxis can occur until the 10th postoperative day. Due to the risk of secondary bleeding, the patient discharge process may be complicated for both the patient and clinician. Thus far, no studies have explored massive intraand postoperative bleeding in patients undergoing orthognathic surgery. Therefore, this study was performed to determine the prevalence of postoperative secondary bleeding and its correlation with intraoperative massive bleeding in patients undergoing orthognathic surgery.Materials and methods: A total of 206 orthognathic surgery patients were included in this retrospective study. Perioperative data was collected by determining the number of patients who referred to the clinic for treatment of secondary bleeding. The following parameters were recorded: occurrence of intraoperative massive bleeding, preand postoperative haemoglobin and haematocrit values, intraoperative projected bleeding, amount of intravenous liquid needed, and length of hospital stay. In addition, the association between secondary and intraoperative massive bleeding was investigated.Results: Two of 206 patients (0.97%) experienced both massive intraoperative bleeding and massive postoperative bleeding.Conclusion: Intraand postoperative massive bleeding occurred only in a small number of patients; thus, longer hospitalisation and strict follow-up of this small group of patients may be required.Öğe Preventive and therapeutic effects of relaxin on bisphosphonate-related osteonecrosis of the jaw: An experimental study in rats(Universidade Estadual Paulista, Institute of Science and Technology of Sao Jose dos Campos, 2020) Develi, Tuba; Uçkan, Sina; Bayram, Burak; Deniz, Kağan; Erdem, Şaban Remzi; Özdemir, Binnaz Handan; Başçıl Tütüncü, Neslihan; Bacanlı, DidemObjective: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a challenging complication of chronic bisphosphonate (BP) use. The hormone relaxin is able to induce the multistep differentiation process of human osteoclastogenesis, exhibits anti-fibrotic and anti-inflammatory actions, and promotes vasodilatation, wound healing, and angiogenesis. The present study aimed to evaluate the effects of relaxin in the prevention and management of BRONJ. Material and Methods: Thirty-six male Sprague Dawley rats were randomly divided into four groups. Rats in group 1 (n = 10) received relaxin and BP simultaneously for 12 weeks. Rats in group 2 (n = 10) received injections of BP for 12 weeks, followed by relaxin for another 12 weeks. Rats in group 3 (n = 10) received only BP injections, and those in group 4 (control, n = 6) received only saline. Necrosis and inflammation in the rats’ mandibles were evaluated as indicators of BRONJ. Results: Necrosis and inflammation were not detected in group 1 (BP + relaxin). In group 3 (BP only), incidence rates of necrosis and inflammation were 90% and 60%, respectively. Conclusions: Our findings suggest that relaxin may be potently effective in preventing BRONJ and have some benefit in the treatment of existing BRONJ.Öğe Superficial cervical plexus block for orthognathic surgery(Elsevier, 2021) Çiftçi, Bahadır; Develi, Tuba; Münevveroğlu, Sümer; Ekinci, MürselTo the Editor:Cervical plexus block (CPB) is used to treat postoperativepain after various head and neck surgeries1, and this regionalanaesthesia technique may also be a good choice for painmanagement following orthognathic surgery. We report ourexperience of ultrasound-guided superficial cervical plexusblock in a patient who underwent bilateral sagittal splitosteotomy.Öğe The effect of intraarticular botulinum toxin-A injection on symptoms of temporomandibular joint disorder(Elsevier, 2022) Sarı, Bilal Cemşit; Develi, TubaIntroduction: Application of arthrocentesis in temporomandibular joint disorders preferred and suggested therapeutic treatment option in recent years. This study was designed to investigate and compare the effect of intra-articular injection of botulinum toxin-A (Btx-A) on pain and mouth opening after arthrocentesis in nonreduction disc displacement.Materials and methods: This restrospective study was conducted on 30 patients with a visual analogue scale is higher than five and limited mouth opening. Patients were divided into 2 groups as conventional arthrocent-esis group (group A) and intra-articular Btx-A injection following arthrocentesis group (group B). Maximum mouth openining and temporomandibular joint pain were measured in preoperative (t0) and at postopera-tive 1st-week (t1), 1st-month (t2) and 6th-month (t3).Results: When VAS scores of group A and group B were examined, no statistical difference was observed at t0 and t1 time intervals; an increased in mouth opening values and decreased VAS score values were observed in both groups in the 1st month (t2) and 6th (t3) months, mostly in group A.Conclusion: I_ntra-articular injection of Btx-A following arthrocentesis can induce mouth opening and reduce the pain and dysfunction in patients with anterior disc displacement.
