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    Effects of pamidronate administration on tooth eruption and mandibular growth in new born rats
    (2017) Tuncer, İbrahim; Delilbaşı, Çağrı Barış; Deniz, Ediz; Soluk Tekkeşin, Merva; Olgaç, Vakur; Şençift, Kemal
    Purpose: Bisphosphonates are commonly used drugs in pediatric patients in the treatment of osteoporotic diseases and various types of cancers. The purpose of this study was to evaluate the effects of pamidronate administration on mandibular growth and tooth eruption in new born rats. Materials and Methods: Forty Sprague Dawley rats were included in the study and divided into four groups as; 14th day pamidronate group, 30th day pamidronate group, 14th day control group and 30th day control group. Pamidronate groups were daily injected with 1.25 µg/g pamidronate disodium subcutaneously whereas control groups were injected with sterile saline. Eruption levels of lower incisor and molar teeth were assessed macroscopically. Mandibular growth was assessed by measuring reference points in cone beam tomography. Histological and histomorphometric examinations were performed under light microscope to evaluate tooth morphology and number of osteoclasts. Results: Retardation in mandibular growth, decrease in number of osteoclasts, delay in tooth eruption, degeneration in both tooth morphology and structure were observed in the pamidronate groups compared to control groups. Conclusion: Pamidronate administration during growth and development stage may adversely affect tooth eruption and mandibular growth in new born rats.
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    Evaluation of light-emitting diode photobiomodulation on bone healing of rat calvarial defects
    (Taylor & Francis, 2015) Deniz, Ediz; Arslan, Ahmet Hamdi; Diker, Nurettin Yağmur; Olgaç, Vakur; Kılıç, Ertuğrul
    One of the major problems in modern dentistry is the recovery of bone defects. The aim of this prospective experimental study was to evaluate the effect of light-emitting diode (LED) photobiomodulation therapy on bone healing of rat calvarial defects. Twenty-eight male Sprague Dawley rats were used for the study. Critical size defects with 5 mm diameter were made with a trephine bur used in a low-speed handpiece under continuous sterile saline irrigation on each side of the sagittal suture. All critical size defects on the right side were filled with corticocancellous bone graft material and all the defects on the left side were left empty. The animals were randomly divided into two groups of 14 rats each. Group I received LED therapy and Group II did not receive any therapy. OsseoPulse® LED device (Biolux Research Ltd.) 618 nm wavelength and 20 mW/cm2 output power irradiation was started immediately after the surgery and was applied for 20 minutes at 24-h intervals for 7 and 14 days. In each group, seven rats were sacrificed on the 8th day and the remaining rats were sacrificed on the 15th day. Bone healing of the non-grafted side was statistically significant in Group I on both 8th day and 15th day; on the other hand, in the grafted side, enhanced bone healing was dominantly observed on the 15th day in Group I, compared to Group II, although the difference was not significant. Within the limits of this study, the findings suggested that LED therapy might have a favourable effect in the early phase of bone healing.
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    Monostotic fibrous dysplasia of the mandible
    (Longdom Publishing SL, 2014) Delilbaşı, Çağrı; Deniz, Ediz; Doğan Ekici, Işın
    Fibrous Dysplasia (FD) is a developmental disorder of bone that can affect one bone (monostotic type) or multiple bones (polyostotic type). The disease can be associated with hyperpigmentation and endocrinological disorders. It is usually observed in adolescents and young adults and comprises 7% of benign bone tumors. It has a predilection for long bones as well as the craniofacial skeleton. The etiology of FD is not clear but genetic predisposition is suspected. The diagnosis is based on radiological and histopathological examination. There are different treatment approaches including monitoring, medical treatment or surgery. In this article, we present a case of monostotic mandibular fibrous dysplasia of the mandible with clinical, radiographic and histopathological features.