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Öğe A case of primary hypoparathyroidism presenting with acute kidney injury secondary to rhabdomyolysis(Hindawi Publishing Corporation, 2016) Şumnu, Abdullah; Aydın, Zeki; Gürsu, Meltem; Uzun, Sami; Karadağ, Serhat; Cebeci, Egemen; Öztürk, Savaş; Kazancıoğlu, RumeyzaHypoparathyroidism is the most common cause of symmetric calcification of the basal ganglia. Herein, a case of primary hypoparathyroidism with severe tetany, rhabdomyolysis, and acute kidney injury is presented. A 26-year-old male was admitted to the emergency clinic with leg pain and cramps, nausea, vomiting, and decreased amount of urine. He had been treated for epilepsy for the last 10 years. He was admitted to the emergency department for leg pain, cramping in the hands and legs, and agitation multiple times within the last six months. He was prescribed antidepressant and antipsychotic medications. He had a blood pressure of 150/90 mmHg, diffuse abdominal tenderness, and abdominal muscle rigidity on physical examination. Pathological laboratory findings were as follows: creatinine, 7.5 mg/dL, calcium, 3.7 mg/dL, alanine transaminase, 4349 U/L, aspartate transaminase, 5237 U/L, creatine phosphokinase, 262.000 U/L, and parathyroid hormone, 0 pg/mL.There were bilateral symmetrical calcifications in basal ganglia and the cerebellum on computerized tomography. He was diagnosed as primary hypoparathyroidism and acute kidney injury secondary to severe rhabdomyolysis. Brain calcifications, although rare, should be considered in dealing with patients with neurological symptoms, symmetrical cranial calcifications, and calcium metabolism abnormalities.Öğe Characteristics of primary glomerular disease patients with hematuria in Turkey: The data from TSN-Gold working group(Oxford University Press, 2020) Şumnu, Abdullah; Türkmen, Kültigin; Cebeci, Egemen; Türkmen, Aydın; Eren, Necmi; Seyahi, Nurhan; Oruç, Ayşegül; Dede, Fatih; Derici, Ülver; Baştürk, Taner; Şahin, Garip; Sipahioğlu, Murat; Manga Şahin, Gülizar; Tatar, Erhan; Dursun, Belda; Sipahi, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Memnune Sena; Güngör, Özkan; Kutlay, Sim; Bicik Bahçebaşı, Zerrin; Şahin, İdris; Kurultak, İlhan; Sevinç, Can; Yılmaz, Zülfikar; Turan Kazancıoğlu, Rümeyza; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Gül, Cuma Bülent; Altun, Bülent; Paydaş, Saime; Uzun, Sami; İstemihan, Zülal; Ergül, Metin; Dinçer, Mevlüt Tamer; Güllülü, Mustafa; Pişkinpaşa, Serhan Vahit; Akçay, Ömer Faruk; Ünsal, Abdulkadir; Koyuncu, Sümeyra; Gök, Mahmut; Öztürk, Savaş[Abstract Not Available]Öğe Characteristics of primary glomerular diseases patients with hematuria in Turkey: The data from TSN-GOLD Working Group(Springer, 2021) Şumnu, Abdullah; Türkmen, Kültigin; Cebeci, Egemen; Türkmen, Aydın; Eren, Necmi; Seyahi, Nurhan; Oruç, Ayşegül; Dede, Fatih; Derici, Ülver; Baştürk, Taner; Şahin, Garip; Sipahioğlu, Murat; Manga Şahin, Gülizar; Tatar, Erhan; Dursun, Belda; Sipahi, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Sena; Güngör, Özkan; Kutlay, Sim; Bicik Bahçebaşı, Zerrin; Şahin, İdris; Kurultak, İlhan; Sevinç, Can; Yılmaz, Zülfikar; Turan Kazancıoğlu, Rümeyza; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Deren; Gül, Bülent; Altun, Bülent; Paydaş, Saime; Uzun, Sami; İstemihan, Zulal; Ergül, Metin; Dinçer, Mevlüt Tamer; Güllülü, Mustafa; Pişkinpaşa, Serhan; Akçay, Ömer Faruk; Ünsal, Abdulkadir; Koyuncu, Sümeyra; Gök, Mahmut; Öztürk, SavaşPurpose Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. Methods Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. Results Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). Conclusion This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.Öğe Epidemiological features of primary glomerular disease in Turkey: A multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group(BioMed Central Ltd, 2020) Türkmen, Aydın; Şumnu, Abdullah; Cebeci, Egemen; Yazıcı, Halil; Eren, Necmi; Seyahi, Nurhan; Dilek, Kamil; Dede, Fatih; Derici, Ülver; Ünsal, Abdulkadir; Şahin, Garip; Sipahioğlu, Murat; Gök, Mahmut; Tatar, Erhan; Dursun, Belda; Sipahi, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Sena; Güngör, Özkan; Kutlay, Sim; Bicik Bahçebaşı, Zerrin; Şahin, İdris; Kurultak, İlhan; Türkmen, Kültigin; Yılmaz, Zülfikar; Turan Kazancıoğlu, Rümeyza; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Duriye Deren; Gül, Cuma Bülent; Arıcı, Mustafa; Paydaş, Saime; Güven Taymez, Dilek; Küçük, Mehmet; Trablus, Sinan; Turgutalp, Kenan; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altıntepe, Lütfullah; Arıkan, İzzet Hakkı; Azak, Alper; Odabaş, Ali Rıza; Manga Şahin, Gülizar; Öztürk, SavaşBackground The largest data on the epidemiology of primary glomerular diseases (PGDs) are obtained from the databases of countries or centers. Here, we present the extended results of the Primary Glomerular Diseases Study of the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group. Methods Data of patients who underwent renal biopsy and received the diagnosis of PGD were recorded in the database prepared for the study. A total of 4399 patients from 47 centers were evaluated between May 2009 and May 2019. The data obtained at the time of kidney biopsy were analyzed. After the exclusion of patients without light microscopy and immunofluorescence microscopy findings, a total of 3875 patients were included in the study. Results The mean age was 41.5 +/- 14.9 years. 1690 patients were female (43.6%) and 2185 (56.3%) were male. Nephrotic syndrome was the most common biopsy indication (51.7%). This was followed by asymptomatic urinary abnormalities (18.3%) and nephritic syndrome (17.8%). The most common PGD was IgA nephropathy (25.7%) followed by membranous nephropathy (25.6%) and focal segmental glomerulosclerosis (21.9%). The mean total number of glomeruli per biopsy was 17 +/- 10. The mean baseline systolic blood pressure was 130 +/- 20 mmHg and diastolic blood pressure was 81 +/- 12 mmHg. The median proteinuria, serum creatinine, estimated GFR, and mean albumin values were 3300 (IQR: 1467-6307) mg/day, 1.0 (IQR: 0.7-1.6) mg/dL, 82.9 (IQR: 47.0-113.0) mL/min and 3.2 +/- 0.9 g/dL, respectively. Conclusions The distribution of PGDs in Turkey has become similar to that in other European countries. IgA nephropathy diagnosed via renal biopsy has become more prevalent compared to membranous nephropathy.Öğe Immunosuppressive treatment results in patients with primary iga nephropathy in Türkiye: A nationwide study(Oxford University Press, 2023) Oruç, Ayşegül; Şumnu, Abdullah; Türkmen, Aydın; Baştürk, Taner; Cebeci, Egemen; Turgutalp, Kenan; Çetinkaya, Hakkı; Güllülül, Mustafa[Abstract Not Available]Öğe Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group(2024) Oruç, Ayşegül; Türkmen, Aydın; Baştürk, Taner; Cebeci, Egemen; Turgutalp, Kenan; Çetinkaya, Hakkı; Üzerk Kibar, Müge; Seyahi, Nurhan; Tatar, Erhan; Ergül, Metin; Derici, Ülver; Aylı, Mehmet Deniz; Pınar, Musa; Bakar, Betül; Kazancıoğlu, Rümeyza; Yıldız, Abdülmecit; Dirim, Ahmet Burak; Yılmaz, Zülfükar; Türkmen, Kültigin; Tunca, Onur; Koç, Mehmet; Kutlay, Sim; Micozkadıoğlu, Hasan; Azak, Alper; Boztepe, Burcu; Üstündağ, Sedat; Şafak Öztürk, Seda; Ünsal, Abdulkadir; Karadağ, Serhat; Şahin, Gülizar; Coşgun Yenigün, Ezgi; Eren, Necmi; Güllülü, Mustafa; Gürsu, Meltem; Öztürk, Savaş; Şumnu, AbdullahBackground: Immunoglobulin A (IgA) nephropathy (IgAN) treatment consists of maximal supportive care and, for high-risk individuals, immunosuppressive treatment (IST). There are conflicting results regarding IST. Therefore, we aimed to investigate IST results among IgAN patients in Turkiye. Method: The data of 1656 IgAN patients in the Primary Glomerular Diseases Study of the Turkish Society of Nephrology Glomerular Diseases Study Group were analyzed. A total of 408 primary IgAN patients treated with IST (65.4% male, mean age 38.4 ± 12.5 years, follow-up 30 (3–218) months) were included and divided into two groups according to treatment protocols (isolated corticosteroid [CS] 70.6% and combined IST 29.4%). Treatment responses, associated factors were analyzed. Results: Remission (66.7% partial, 33.7% complete) was achieved in 74.7% of patients. Baseline systolic blood pressure, mean arterial pressure, and proteinuria levels were lower in responsives. Remission was achieved at significantly higher rates in the CS group (78% vs. 66.7%, p = 0.016). Partial remission was the prominent remission type. The remission rate was significantly higher among patients with segmental sclerosis compared to those without (60.4% vs. 49%, p = 0.047). In the multivariate analysis, MEST-C S1 (HR 1.43, 95% CI 1.08–1.89, p = 0.013), MEST-C T1 (HR 0.68, 95% CI 0.51–0.91, p = 0.008) and combined IST (HR 0.66, 95% CI 0.49–0.91, p = 0.009) were found to be significant regarding remission. Conclusion: CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.Öğe Is there any effect of urogenital cysts on semen parameters in autosomal dominant polycystic kidney disease?(Turkish Society of Nephrology, 2015) Uzun, Sami; Öztürk, Savaş; Gürsu, Meltem; Diker, Mustafa; Akman, Tolga; Şumnu, Abdullah; Karadağ, Serhat; Zeki, Aydın; Cebeci, Egemen; Alpay, Nadir; Kırış, Adem; Sarılar, Ömer; Kazancıoğlu, RumeyzaOBJECTIVE: Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disease with cysts in many organs including the urogenital tract. The aim of the study was to evaluate the relationship between urogenital cysts, semen pathologies and infertility in ADPKD. MATERIAL and METHODS: Male ADPKD patients aged 18-60 with creatinine clearance years higher than 60 ml/min were included. All patients had magnetic resonance imaging of the urinary system and pelvis, scrotal Doppler ultrasonography and sperm analysis. The results were compared with those of a healthy control group. RESULTS: 27 patients and 17 volunteers were included. Seminal vesicle and prostate cysts were detected in four (15%) and six (22%) patients, respectively. Five of the 23 married patients (21%) had infertility and this rate was higher than in the control group (p=0.044). The ratio of sperms with normal morphology and progressive motility was lower, and the rate of hypospermia, oligozoospermia, azospermia, asthenozoospermia and teratozoospermia were higher in the patient group. There was no significant difference between patients with/without urogenital cysts regarding seminal pathologies. CONCLUSION: Seminal abnormalities and infertility are more frequent in patients with ADPKD. Defects in spermatogenesis and sperm motility may be related to urogenital cysts as well as ciliary pathologies. There is a need for further studies evaluating the role of urogenital cysts in semen pathologies.Öğe Relationship of adma levels with cardiovascular parameters in patients with peritoneal dialysis: A bioimpedance analysis study(AVES, 2018) Şumnu, Abdullah; Cebeci, Egemen; Öztürk, Savaş; Gürsu, Meltem; Kasapoğlu, Ergün; Özkan, Oktay; Gümüş, Alper; Gürdal, Ahmet; Karadağ, Serhat; Kumbasar, Abdulbaki; Kazancıoğlu, RümeyzaObjective: Asymmetric dimethylarginine (ADMA) is known as a non-traditional risk factor for cardiovascular disease. Considering the increased prevalence of hypervolemia and heart failure in patients with peritoneal dialysis (PD), we aimed to investigate the relationship of ADMA with other biochemical parameters, echocardiographic findings, and results of bioimpedance analysis, which is a method for the determination of body fluid distribution in detail. Methods: The study was conducted on 21 patients with chronic PD. Bioimpedance was evaluated by Body Composition Monitor H02.201.1 (R). ADMA level was analyzed by an ELISA kit. Results: The mean ADMA level was 87.6 +/- 58.2 (18.54-247.34) mu mol/L. The mean ADMA level in patients with hypertension was significantly higher than those with normal blood pressure (95.8 +/- 58.8 mu mol/L and 41.0 +/- 27.9 mu mol/L, respectively; p=0.045). In univariate analysis, the parameters associated with serum ADMA levels were uric acid (r=0.681, p=0.001), left ventricular end-systolic diameter (LVESD) (r=0.509, p=0.019), intracellular water (ICW) (r=0.606, p=0.004), extracellular water (r=0.471, p=0.031), dialysate-to-plasma (D/P) creatinine ratio (r=0.452, p=0.04), body surface area (r=0.52, p=0.016), total body water (r=0.581, p=0.006), and lean tissue mass (r=0.528, p=0.014). In multivariate analysis, only uric acid level, ICW, LVESD, and D/P creatinine were found to be significantly associated with ADMA. Conclusion: Serum ADMA level may be a useful marker to detect cardiovascular risk in patients with PD. Serum uric acid and LVESD are important parameters related to ADMA levels in patients with PD. Bioimpedance spectroscopy findings support the association of ADMA with body fluid volume.Öğe Role of ankle brachial index measured by simple automatic sphygmomanometers in predicting postoperative kidney function in patients undergoing major cardiac surgery(Asociación Regional de Diálisis y Trasplantes Renales, 2021) Şumnu, Abdullah; Öztürk, Savaş; Çavdar, Eyüp; İlal Mert, Fatma Tuba; Cebeci, Egemen; Karaali, Zeynep; Şahin, MazlumIntroduction: Ankle-brachial pressure index is an objective, noninvasive test for predicting subclinical atherosclerotic diseases. We investigated the role of ankle-brachial pressure index measured with automated sphygmomanometer devices in the prediction of the development of acute kidney injury in patients undergoing major cardiac surgery. Methods: This single-centered, cross-sectional, and observational study was performed on 80 (66 males and 14 females, 58 +/- 10 years) patients undergone cardiac surgery. Complete anamnesis, laboratory tests, intravenous fluids, medications, blood products, and all perioperative procedures were recorded in all patients before the surgery. Two automated sphygmomanometer devices giving equivalent results were used for measuring Ankle-brachial pressure index. The data in the first two days after the surgery were used for analysis. The criteria of AKIN were used in the diagnosis of acute kidney injury. Results: Twenty-one (23%) patients developed acute kidney injury in the postoperative period. None of the patients needed renal replacement therapy or died. There was no significant difference between mean ankle-brachial pressure index levels of patients with and without acute kidney injury (1.04 +/- 0.17 and 1.06 +/- 0.19, respectively, p=0.554). The mean ankle-brachial pressure index was significantly lower in patients with perioperative complications that cause hemodynamic instability (1.07 +/- 0.14, 0.96 +/- 0.13, p=0.016). On the multivariate analysis model, only perioperative hemodynamic complication development was found to be related to postoperative acute kidney injury. Conclusion: Anklebrachial pressure index may have a role in predicting perioperative hemodynamic complications, which may cause acute kidney injury in patients undergoing major surgery. Simple automatic blood pressure devices can be used in daily practice for ankle-brachial pressure index measurement instead of complex and expensive doppler devices.Öğe Role of ankle-brachial index measured with simple automated blood pressure devices in predicting the postoperative kidney functions in non-cardiac patients with low renal risk(AVES, 2022) Şumnu, Abdullah; İslamoğlu, Zeki; Karadağ, Serhat; Uzun, Sami; Cebeci, Egemen; Yiğit, Namık; Hut, Adnan; Akıncı, Muzaffer; Öztürk, SavaşObjective: Ankle-brachial index indirectly shows subclinical atherosclerosis in extremity vessels. No study investigated the role of ankle-brachial index measured with simple automated devices in the prediction of postoperative acute kidney injury in non-cardiac surgery patients with a low risk of acute kidney injury. Methods: The single-center, cross-sectional, observational study included patients who were scheduled for operation under general anesthesia. The preoperative ankle-brachial index was measured with two Omron M2 Basic (Hem 7120-E) automatic sphingomanometry devices for the detection of the arm and leg systolic blood pressure values. The ratio of ankle higher systolic blood pressure to brachial higher systolic blood pressure was recorded as ankle-brachial index. Results: A total of 100 (48 women, mean age of 57.5 +/- 14.1 years) patients were included. The median ankle-brachial index value was 1.12 (right ABI: 1.11 +/- 0.09 and left ABI: 1.12 +/- 0.10). The level of ankle-brachial index in patients with acute kidney injury was not significantly different than in patients without acute kidney injury. Serum creatinine value was increased on the second day compared to baseline in 38 (38%) of patients. There was no difference in terms of ankle-brachial index levels in patients with and without an increase in creatinine levels. In the linear regression model including the parameters that were found to be related to the change in the second-day serum creatinine in univariate analyses, left ankle-brachial index showed a negatively significant relationship with the second-day serum creatinine change. Conclusion: Ankle-brachial index is useful in the assessment of perioperative renal function and acute kidney injury risk in non-cardiac surgery patient populations.Öğe The relationship between severity of interstitial fibrosis and anemia in patient with primary glomerulonephritis: The data from TSN-Gold working group(Oxford University Press, 2020) Cebeci, Egemen; Turgutalp, Kenan; Öztürk, Savaş; Özlük, Yasemin; Gökçay Bek, Sibel; Şumnu, Abdullah; Seyahi, Nurhan; Yavuz, Mahmut; Pişkinpaşa, Serhan Vahit; Akçay, Ömer Faruk; Sakacı, Tamer; Şahin, Garip; Tokgöz, Bülent; Manga Şahin, Gülizar; Bozacı, İlter; Dursun, Belda; Sipahi, Savaş; Özdemir Kayalar, Arzu; Süleymanlar, Gültekin; Ulu, Memnune Sena; Güzel, Fatma Betül; Kutlay, Sim; Parmaksız, Ergün; Köz, Süleyman; Kurultak, İlhan; Selçuk, Nedim Yılmaz; Yıldırım, Yaşar; Gürsu, Meltem; Çavdar, Caner; Timuçin, Meryem; Aydın, Zeki; Oygar, Deren; Kahvecioğlu, Serdar; Üzerk Kibar, Müge; Torun, Dilek; Güven Taymez, Dilek; Küçük, Mehmet; Demir, Serap; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altıntepe, Lüftullah; Koç, Mehmet; Azak, Alper; Odabaş, Ali Rıza; Yılmaz, Zülfikar; Paydaş, Saime[Abstract Not Available]
