Yazar "Can, Demet" seçeneğine göre listele
Listeleniyor 1 - 11 / 11
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A comparative evaluation of clinical and laboratory findings and treatment costs for sublingual and subcutaneous immunotherapy in children with allergic rhinitis and asthma(Wiley, 2018) Eren, Seçil; Gülez, Nesrin; Karkıner, Canan Şule; Kanık, Esra Toprak; Bahçeci, Semiha; Karaman, Sait; Nacaroğlu, Hikmet Tekin; Akçal, Ömer; Genel, Ferah; Can, Demet[Abstract Not Available]Öğe Adverse drug reactions affecting treatment adherence in first-line treatment of asthma: An observational study(NLM (Medline), 2023) Bahçeci Erdem, Semiha; Nacaroğlu, Hikmet Tekin; Can, DemetBACKGROUND: Asthma is the most common chronic lung disease among children. International guidelines recommend inhaled corticosteroids (ICS) as the first-line daily controller therapy for children with asthma and leukotriene receptor antagonists (LTRA) as the second alternative therapy. Adherence to treatment is the most significant component to optimize the benefits of therapy in asthma. OBJECTIVE: This study aims to investigate the frequency of drug discontinuation due to adverse drug reactions (ADRs) that affect adherence to treatment in children with asthma or asthma and allergic rhinitis using LTRA or ICS as monotherapy. METHODS: The subjects aged 4-18 years with asthma or asthma and allergic rhinitis and using montelukast or ICS as monotherapy were included in the study. They were evaluated in terms of ADRs affecting adherence to treatment in the first and third months of treatment. RESULTS: A total of 468 cases, 356 of whom received montelukast monotherapy and 112 of whom received ICS treatment, with a mean age of 9.10 ± 3.08 (4-17) years, were included in the study. Males constituted 65.6% of the total cases (n = 307). In the first month of follow-up of the cases, it was observed that 4.8% (n = 17) of the patients in the montelukast group could not continue the treatment due to ADR. It was determined that the drug discontinuation rate in the montelukast group in the first month was significantly higher than in the ICS group (P = 0.016), and the risk of drug discontinuation due to ADR in the montelukast group was 1.333 (95% CI, 1.26-1.40) times higher. CONCLUSIONS: As a result, it was observed that the drug was discontinued due to ADR at a higher rate in children with asthma who received montelukast monotherapy compared to those who received ICS monotherapy.Öğe Awareness and knowledge of children with asthma who treated with subkutan immunotherapy(Behçet Uz Çocuk Hastalıkları ve Cerrahisi Eğitim ve Araştırma Hastanesi, 2021) Akçal, Ömer; Taşkırdı, İlke; Özen, Selime; Akay Hacı, İdil; Kaya, Mehmet Şirin; Toprak Kanık, Esra; Karaman, Sait; Bahçeci Erdem, Semiha; Nacaroğlu, Hikmet Tekin; Karkıner, Canan Şule; Can, DemetObjective: Asthma is one of the most common chronic diseases of childhood. Many studies have shown that education positively affects asthma control and patients' quality of life. In this study, it was aimed to measure the awareness levels of children who have been under observation for a long time and who underwent Allergen Specific Immunotherapy (AIT). Methods: Patients with asthma, asthma & allergic rhinitis and/or rhinoconjunctivitis who received subcutaneous AIT between July 2019 and December 2019 were included in our prospective case-control study. A questionnaire was applied to each patient, in which both the levels of awareness related to their disease and AIT, as well as their knowledge of the allergens and prevention measures they were sensitive to were measured. The results were examined. Age, gender, type of allergic diseases, allergen type, AIT time were evaluated statistically. Results: 82 cases (48 boys and 34 girls) were included in the study. The number of patients who know the name of the disease correctly is 68 (82.9%); The number of patients who knew allergens to be sensitive was found to be 47 (57.3%). It was observed that 15%-72% of the cases had information about asthma disease. Age, gender and diseases of the patients were not statistically different. Conclusion: In our study, it was observed that our children were highly aware of especially about sports and environmental protection methods. It is essential to raise awareness of patients and parents for increase treatment success and control the asthma.Öğe CD4+CD25+CD127loFOXP3+ cell in food allergy: Does it predict anaphylaxis?(Codon Publications, 2023) Bahçeci Erdem, Semiha; Genel, Ferah; Nacaroğlu, Hikmet Tekin; Karaman, Sait; Ünsal Karkıner, Canan Şule; Sürücü, Murat; Can, DemetBackground: Food allergy (FA), hence the incidence of food anaphylaxis, is a public health problem that has increased in recent years. There are still no biomarkers for patients with FA to predict severe allergic reactions such as anaphylaxis. Objective: There is limited information on whether regulatory T (Treg) cell levels are a biomarker that predicts clinical severity in cases presenting with FA, and which patients are at a greater risk for anaphylaxis. Methods: A total of 70 children were included in the study: 25 who had IgE-mediated cow’s milk protein allergy (CMPA) and presented with non-anaphylactic symptoms (FA/A?), 16 who had IgE-mediated CMPA and presented with anaphylaxis (FA/A+) (a total of 41 FA cases), and a control group consisting of 29 children without FA. The study was conducted by performing CD4+CD25+CD127loFOXP3+ cell flow cytometric analysis during resting at least 2 weeks after the elimination diet to FA subjects. Results: When the FA group was compared with healthy control subjects, CD4+CD25+CD127loFOXP3+ cell rates were found to be significantly lower in the FA group (p < 0.001). When the FA/A? and FA/A+ groups and the control group were compared in terms of CD4+CD25+CD127loFOXP3+ cell ratios, they were significantly lower in the FA/A? and FA/A+ groups compared to the control group (p < 0.001). Conclusions: Although there was no significant difference between the FA/A+ group and the FA/ A? group in terms of CD4+CD25+CD127loFOXP3+ cells, our study is important, as it is the first pediatric study we know to investigate whether CD4+CD25+CD127loFOXP3+cells in FA p redict anaphylaxis.Öğe Characteristics of food allergy in children: National multicenter study(Wiley, 2019) Bingöl, Ayşen; Uygun, Kocacık; Akdemir, Meltem; Erengin, Hakan; Bozdoğan, Günseli; Bingöl, Gülbin; Orhan, Fazıl; Büyüktiryaki, Betül; Şekerel, Bülent Enis; Kılıç, Mehmet; Saçkesen, Cansin; Eren Akarcan, Sanem; Demir, Esen; Köse, Şirin; Asilsoy, Suna; Kan, Ahmet; Türktaş, İpek; Arikoğlu, Tuğba; Kuyucu, Semanur; Sipahi, Seyhan; Tamay, Zeynep; Nacaroğlu, Tekin; Özdemir, Pınar Gökmirza; Yazıcıoğlu, Mehtap; Çekiç, Şükrü; Sapan, Nihat; Zeyrek, Dost; Doğruel, Dilek; Karakoç Aydıner, Elif; Özen, Ahmet Oğuzhan; Can, Ceren; Ertuğrul, Ayşin; Birol Bostancı, İlknur; Akçal, Ömer; Can, Demet; Arik Yılmaz, Ebru; Anıl, Hülya; Harmancı, Koray; Külhaş Çelik, İlknur; Civelek, Ersoy; Çokuğraş, Haluk; Şenol, Handan Duman; Tuncel, Tuba; Ufuk Altıntaş, DeryaBackground : Food allergies impose a significant burden on the life of the child and the family. In this study, to determine the demographic characteristics of food allergies, we investigated the characteristics of patients with food allergies in different regions of Pediatric Allergy- Immunology departments in Turkey. Method : Turkey ' s National Study of Allergy and Clinical Immunology Society has conducted a Study Group on Food Allergies. 25 centers participated in this multicenter, cross- sectional and descriptive study.Öğe Effects of anatolian propolis and hypertonic saline combination nasal spray on allergic rhinitis symptoms: a prospective, multicenter study(2024) Cingi, Cemal; Bayar Muluk, Nuray; Çukurova, İbrahim; Dündar, Rıza; Osma, Üstün; Bal, Cengiz; Zirek, Alaattin; Budak, Ali; Resuli, Ali Seyed; Selimoğlu, Asif; Tanuğur Samancı, Aslı Elif; Karaoğullarından, Ayşe; Yılmaz, Begüm; Arslan, Bengi; Sizer, Bilal; Cihan, Celalettin; Koca, Çiğdem Fırat; Avcı, Deniz; Aydenizöz, Doğukan; Ünver, Ethem; Alaskarov, Elvin; Gülmez, Emrah; Gündoğan, Fatih; Günay, Gözde; Çetiner, Hasan; Güngör, Hilal; Salcan, İsmail; Gündoğan, Mahmut Emre; Akbay, Makbule Özlem; Akdağ, Mehmet; Kaplama, Mehmet Erkan; Yaşar, Mehmet; Koparal, Mehtap; Kar, Murat; Altıntaş, Mustafa; Torun, Mümtaz Taner; Bozan, Nazım; Sarı, Neslihan; Susaman, Nihat; Küçük, Nurten; Erdoğan, Osman; Gül, Osman; Sancaklı, Özlem; Kundi, Pınar; Budak, Rezzan Okyay; Karaman, Sait; Taşar, Soner; Demir, Songül; Belli, Şeyda; Yağcı, Tarık; Bilici, Taylan; Çelik, Turgut; Yıldırım, Yavuz Sultan Selim; Atayoğlu, Ali Timuçin; Irkan, Reşat Kubilay; Zorlu, Duygu; Can, DemetObjectives: This study aimed to evaluate how Rhinapi nasal spray affects symptoms of allergic rhinitis. Methods: In this prospective, multicenter, observational study, 10,000 patients (comprising 5028 males and 4972 females) exhibiting symptoms of allergic rhinitis (namely, nasal discharge, sneezing, nasal itching, and nasal obstruction) from different centers in different regions of Turkey were enrolled in the study between March 2022 and March 2023. All the patients wanted to participate in the study and were administered Rhinapi one puff to each nostril three times a day, for a period of 3 weeks. Total symptom scores, quality of life (QoL) scores, and otolaryngological examination scores were evaluated before and 3 weeks after treatment. Results: The scores for discharge from the nose, sneezing, nasal pruritus, and blockage of the nose all indicated improvement when compared to pre-medication and post-medication. This difference achieved statistical significance (P < .001). The mean total symptom score fell following treatment (P < .001): whilst the score was 11.09 +/- 3.41 before administering Rhinapi; after administration, the average score was 6.23 +/- 2.41. The mean QoL scores also altered after medication (P < .001), improving from a mean value of 6.44 +/- 1.55 to a mean of 7.31 +/- 1.24. Significant improvement was also noted in the scores for conchal color and degree of edema after the treatment had been administered (P < .001). Conclusion: The study demonstrates that Rhinapi nasal spray decreases total symptom scores, and results in improved QoL and otolaryngological examination scores. Propolis spray may be recommended for patients with allergic rhinitis alongside other treatments.Öğe Markers of inflammation and tolerance development in allergic proctocolitis(Sociedad Argentina de Pediatría, 2018) Nacaroğlu, Hikmet Tekin; Bahçeci Erdem, Semiha; Durgun, Ersin; Karaman, Sait; Erdur, Cahit Barış; Ünsal Karkıner, Canan Şule; Can, DemetBackground. Today, as a result of an increase in the frequency of food protein-induced allergic proctocolitis (FPIAP), there is a need for studies not only to enlighten the pathophysiology of the disease but also to determine simple, non-invasive markers in both diagnosis, and evaluation of the development of tolerance. No study has been found in the literature about the place of neutrophil/ lymphocyte ratio (NLR) and mean platelet volume (MPV), which are easy to calculate and non-invasive markers. Objectives. The purpose is to determine the relation between NLR and MPV with the diagnosis and development of tolerance in children with FPIAP. Methods. In this retrospective cross-sectional study, clinical, demographic symptoms and laboratory findings of patients, monitored with FPIAP diagnosis in allergy and gastroenterology clinics, were acquired from the patient record system. Hemogram values at the time of diagnosis were compared with the values of healthy children of the same age and gender. Results. Among 59 patients diagnosed with FPIAP, males constitute 47.4% and females constitute 52.6%. MPV and platelet crit (PCT) values were significantly high when compared to the control group (n:67) in FPIAP cases (p <0.001). Also, MPV and PCT values were significantly high in non-tolerance developing cases when compared to developing ones (p=0.01). Conclusions. Contrary to NLR, MPV and PCT values have been considered to be good markers in predicting prognosis in cases with FPIAP since they are quick, cost effective and easy to calculate.Öğe Nadir bir anafilaksi nedeni: Soğuk maruziyeti(Dr Behçet Uz Çocuk Hastalıkları ve Cerrahisi, 2018) Topal, Sevgi; Bahçeci, Semiha; Karaman, Sait; Nacaroğlu, Hikmet Tekin; Karkıner, Canan Sule; Can, DemetFiziksel ürtikerin bir formu olan soğuk ürtikeri, cildin soğuk ile teması sonrası mast hücrelerinden histamin ve diğer proinflamatuvar mediatörlerin salınımı ile oluşmaktadır (1). Tüm fiziksel ürtikerler arasında soğuk ürtikeri semptomatik dermografizmden sonra ikinci sıklıktadır (2,3). Soğuğa maruziyet histamin ve diğer proinflamatuvar mediyatörlerin salınımı ile ürtiker ve/veya anjioödem gelişimine neden olabilmektedir (2,4). Tipik olarak soğuk hava, soğuk sıvı ve nesneler ile temas sonrası dakikalar içinde semptomlar ortaya çıkmaktadır. Semptomların ortaya çıkması 2 saate kadar uzayabilir (3). Deri temas yüzeyi daha geniş olduğunda (soğuk suda yüzme vb.) jeneralize ürtiker, dispne, taşikardi, hipotansiyon, bilinç kaybı gibi yaşamı tehdit edebilen sistemik reaksiyonlar gelişebilmektedir (4). Genellikle yalnızca deriyle temas eden bölgede bulgu verir. Semptomların ortalama süresi 4,8-7,9 yıl arasında değişmektedir (3). Soğuk ürtiker sıklığı yaklaşık %0,05 olarak tahmin edilmektedir (3,5). Fiziksel ürtiker çeşitleri içindeki oranı coğrafik özelliklere bağlı olarak değişebilmekte ve sıklığı %5,2 - %33,8 arasındadır (5). Çocuklarda soğuk ile tetiklenen anaflaksi ise çok nadirdir ve literatürde olgu sunumu şeklinde yer almaktadır. Aşağıda soğuk su ile anaflaksi gözlenen iki çocuk olgu sunulmuştur.Öğe Prevalence of allergic rhinitis and risk factors in school children(Aydın Pediatric Society, 2021) Ayanoğlu, Müge; Can, Demet; Nacaroğlu, Hikmet Tekin; Günay, İlker; Kamalı, Hacer; Karkiner, Canan; Özdemir, Ahmet; Doğan, Döne; Bahçeci Erdem, SemihaObjective: To evaluate the prevalence and the risk factors of allergic rhinitis in a particular area. Methods: The main study group consisted of all school children in Kemalpasa district aged 13-14 years. Children with current rhinitis based on responses given in ISAAC questionnaire survey were further evaluated for confirmation. Parents responded to a more detailed questionnaire about allergic diseases and risk factors. Then peak nasal inspiratory flow (PNIF) was evaluated to objectively assess nasal patency. Skin-prick test was performed for ten common allergens. Results: The questionnaire was answered by 90.8% (1373) of children. The prevalence of physician-diagnosed AR was 11.1%. Current rhinitis was found to be 31.3%. Of this group, 55.0% were admitted for the parent questionnaire and tests. Precisely, 90.3% of children accepted PNIF evaluation, and %10.1 of them had a nasal obstruction. Skin-prick tests revealed allergy for at least 1 allergen in 16.6% of children. The present study showed that the children with maternal allergic rhinitis history had 2,18 fold, and the children with seasonal allergic rhinitis had 2,11 fold higher possibility of sensitization to an allergen. The probability of perennial allergic rhinitis was 3,1 fold higher in the children who had siblings with allergic rhinitis. Conclusion: We included all children in a specific age group living in an area in our survey. As well as we found the prevalence of current rhinitis with the ISAAC questionnaire; we also evaluated peak nasal inspiratory flow and used skin-prick tests that yielded objective results.Öğe The clinical spectrum of reactions developed based on paraphenylenediamine hypersensitivity two pediatric cases(Termedia Publishing House, 2015) Nacaro?lu, Hikmet Tekin; Yavuz, Sinan; Basman, Eray; Bahçeci, Semiha Erdem; Taşdemir, Mehmet; Yi?it, Özgül; Can, DemetParaphenylenediamine (PPD) is a blue-black aniline dye commonly used in hair dyes. It is also used in textile and fur dyes, wool dye, dark cosmetics, temporary tattoo hennas, photo baths, and photocopy and printing ink. Paraphenylenediamine, which accelerates the absorption of hair dye and henna tattoos by the skin and helps the formation of the black color, is an allergen. Paraphenylenediamine leads to hypersensitivity reactions, involving allergic and irritant contact dermatitis [1–3]. Since tattoo and hair dyes are now frequently used in younger children, complications of these applications (which are considered harmless and temporary) are appearing in children. In this study, two pediatric patients who presented to our department with clinical symptoms similar to angioedema and allergic contact dermatitis are discussed.Öğe Yumurta allerjisi olan olgularda kızamık-kızamıkçık-kabakulak aşılaması öncesi aşı ile deri prick testi gerekli mi? Aşı güvenle yapılabilir mi?(Dr. Behçet Uz Çocuk Hastalıkları ve Cerrahisi, 2017) Bahçeci, Semiha; Nacaroğlu, Hikmet Tekin; Arı, Hatice Feray; Karaman, Sait; Karkıner, Canan Şule; Toprak Kanık, Esra; Can, DemetAmaç: İçerisinde yumurta proteini bulunan kızamık-kızamıkçık-kabakulak aşısının (KKK) yumurta alerjisi olan hastalarda doğrudan uygulanması önerilmesine karşın literatürde aşı uygulaması sırasında anaflaksi gözlenen olguların bulunması nedeniyle bu konu hem hekim hem de ailelerde sıkıntılara neden olmaktadır. Bu çalışmada, kliniğimizde yumurta alerjisi nedeniyle izlenen, KKK aşı uygulanmış hastalarda aşı sonrası reaksiyon sıklığının ve aşı uygulaması öncesi aşı ile deri prick test uygulamasının gerekliliğinin değerlendirilmesi amaçlanmıştır.Yöntem: Retrospektif kesitsel çalışmamızda Eylül 2013-Mayıs 2015 tarihleri arasında yumurta alerjisi tanısı ile izlenip, KKK aşısı uygulanmış olan 82 hasta değerlendirildi. Bulgular: Tanı anında yaş ortalaması 8,34±7,1ay olan 82 hastanın %37,8'i (n=31) kız idi. Tanısal dağılımına göre hastalar değerlendirildiğinde, %68,3'ü (n=56) atopik dermatit, %8,5'i (n=7) ürtiker/anjioödem, %18,3'ü (n=15) reaktif havayolu hastalığı, %4,9'u (n=4) anafilaksi olarak değerlendirilmişti. KKK aşı uygulaması öncesi %21'ine (n=17) aşı ile deri prick test uygulanmıştı. Anafilaksi tanısı ile izlenen 2 olgu dışında aşı tam doz yapılmış olup, olguların hiçbirinde KKK aşısı uygulaması sonrasında reaksiyon gözlenmemişti. Sonuç: Yumurta alerjili hastalarda KKK aşısı sonrası herhangi bir reaksiyon gözlenmemiştir. Bu hastalarda diğer sağlıklı çocuklardan farklı reaksiyonlar gözlemediğimiz için KKK aşısının diğer aşıların yapıldığı merkezlerde, aşı ile teste ve bölünmüş dozlara gerek kalmadan uygulanmasında sakınca olmadığını düşünüyoruz.
