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    Cellular interactions with bacterial cellulose: Polycaprolactone nanofibrous scaffolds produced by a portable electrohydrodynamic gun for point-of-need wound dressing
    (Wiley, 2018) Aydoğdu, Mehmet Onur; Altun, Esra; Crabbe-Mann, Maryam; Brako, Francis; Koç, Fatma; Özen, Güneş; Kuruca, Serap Erdem; Edirisinghe, Ursula; Luo, C. J.; Gündüz, Oğuzhan; Edirisinghe, Mohan
    Electrospun nanofibrous scaffolds are promising regenerative wound dressing options but have yet to be widely used in practice. The challenge is that nanofibre productions rely on bench-top apparatuses, and the delicate product integrity is hard to preserve before reaching the point of need. Timing is critically important to wound healing. The purpose of this investigation is to produce novel nanofibrous scaffolds using a portable, hand-held gun, which enables production at the wound site in a time-dependent fashion, thereby preserving product integrity. We select bacterial cellulose, a natural hydrophilic biopolymer, and polycaprolactone, a synthetic hydrophobic polymer, to generate composite nanofibres that can tune the scaffold hydrophilicity, which strongly affects cell proliferation. Composite scaffolds made of 8 different ratios of bacterial cellulose and polycaprolactone were successfully electrospun. The morphological features and cell-scaffold interactions were analysed using scanning electron microscopy. The biocompatibility was studied using Saos-2 cell viability test. The scaffolds were found to show good biocompatibility and allow different proliferation rates that varied with the composition of the scaffolds. A nanofibrous dressing that can be accurately moulded and standardised via the portable technique is advantageous for wound healing in practicality and in its consistency through mass production.
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    Novel making of bacterial cellulose blended polymeric fiber bandages
    (Wiley V C H Verlag Gmbh, 2018) Altun, Esra; Aydoğdu, Mehmet Onur; Koç, Fatma; Crabbe-Mann, Maryam; Brako, Francis; Kaur-Matharu, Rupy; Özen, Güneş; Kuruca, Serap Erdem; Edirisinghe, Ursula; Gündüz, Oğuzhan; Edirisinghe, Mohan
    Bacterial cellulose (BC) is a very promising biological material. However, at present its utilization is limited by difficulties in shape forming it. In this Communication, it is shown how this can be overcome by blending it with poly(methylmethacrylate) (PMMA) polymer. BCPMMA fibers are produced by pressurized gyration of blended BCPMMA solutions. Subsequently, BCPMMA bandage-like scaffolds are generated with different blends. The products are investigated to determine their morphological and chemical features. Cell culture and proliferation tests are performed to obtain information on biocompatibility of the scaffolds.