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    Effect of metabolic syndrome on sexual function in pre- and postmenopausal women
    (Taylor & Francis, 2015) Ötünçtemur, Alper; Dursun, Murat; Özbek, Emin; Şahin, Suleyman; Beşiroğlu, Hüseyin; Koklu, İsmail; Polat, Emre Can; Erkoç, Mustafa; Danış, Eyyüp; Bozkurt, Muammer
    Female sexual dysfunction is a prevalent and multidimensional disorder related to many biological, psychological, and social determinants. The authors assessed the effect of one of the many factors affect sexual function-metabolic syndrome-on female sexual function. They equally divided 400 women participants among 4 groups: (a) premenopausal with metabolic syndrome, (b) premenopausal without metabolic syndrome, (c) postmenopausal with metabolic syndrome, and (d) postmenopausal without metabolic syndrome. The authors used the Female Sexual Function Index to assess women's sexual function. Female sexual dysfunction was found more often in both pre- and postmenopausal women with metabolic syndrome (p =.001). Overall Female Sexual Function Index score and satisfaction, pain, and desire domain scores independently of the menopause status showed statistically significant differences across women with metabolic syndrome in comparison with participants with no metabolic syndrome (p <.05). The authors also evaluated the associations among 5 components of metabolic syndrome and Female Sexual Function Index scores. Higher fasting glucose levels were significantly associated with the Female Sexual Function Index score (p <.05). This study shows that sexual dysfunction is more prevalent in pre- and postmenopausal women with the metabolic syndrome.
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    Erectile dysfunction is positively correlated with mean platelet volume and platelet count, but not with eosinophil count in peripheral blood
    (Urology and Nephrology Research Centre, 2015) Ötünçtemur, Alper; Bozkurt, Muammer; Beşiroğlu, Hüseyin; Polat, Emre Can; Özcan, Levent; Özbek, Emin
    Purpose: Increased eosinophil count (EC), mean platelet volume (MPV), and platelet count (PC) are important in vascular disorders which are main factors resulting in endothelial dysfunction. We aimed to investigate the association between MPV, and EC, with erectile dysfunction (ED). Materials and Methods: Two hundred thirty participants (130 patients with ED, and 100 healthy controls) were enrolled in this study. A detailed psychosexual history obtained, and physical, and laboratory examination were performed. International Index of Erectile Function (IIEF)-5 questionnaire was used to evaluate the erectile status objectively. IIEF-5 score was applied to all patients, and IIEF-5 score under 22 was considered as ED. The MPV, PC, and EC were compared between the two groups. Results: The mean age of the patients with ED and control group was 55.62 +/- 8.90 years and 54.19 +/- 4.10 years, respectively. MTV and PC levels were significantly higher in ED group (8.51 +/- 1.00 fL and 8.16 +/- 0.94 fL; 244.59 +/- 57.3 cells/mu L and 230.17 +/- 48.44 cells/mu L, respectively (P <.05). EC and white blood cell count were not significantly different between study and control groups. Conclusions: In our study a relationship was found between elevated WV, and PC with ED. MPV and PC may be used as a biomarker in patients with ED.
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    Low serum insulin-like growth factor-1 in patients with erectile dysfunction
    (BioMed Central Ltd., 2016) Ötünçtemur, Alper; Özbek, Emin; Şahin, Süleyman; Özcan, Levent; Dursun, Murat; Polat, Emre Can; Çekmen, Mustafa Baki; Özsoy, Özgür Doğa; Erkoç, Mustafa; Daniş, Eyüp; Bozkurt, Muammer
    Objective: Endothelial dysfunction and microvascular damage play a crurical role in the pathogenesis of erectile dysfunction (ED). Insulin-like growth factor-1 (IGF-1) is one of the growth factors that have a wide range of biologic effects. IGF-1 is an important mediator of cell growth, differentiation and transformation in various tissues. The purpose of the current study was to determine the association between IGF-1 levels and ED. Materials and methods: All men were evaluated for ED and divided into two groups: 80 patients suffering from ED for > 1 year and 80 subjects without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. IGF-1 levels were measured in serum by an automated chemiluminescence immunoassay. The relationship between IGF-1 levels and ED scores in patients was statistically evaluated. Results: The mean age of patients in ED group was 60.4 ± 11.3 years and 55.4 ± 9.6 in control group. The plasma IGF-1 levels were significantly lower in ED than in control group (96.5 ± 38.3 and 132.5 ± 53.3 ng/ mL, respectively, P < 0.001). The IGF-1 levels were positively correlated with ED score (r = 0.623, P < 0.01). Conclusion: In this study serum IGF-1 levels were found to be associated with endothelial dysfunction that predicts ED. Serum IGF-1 level appears to be a specific predictor of ED, and it might be used in early prediction of ED in male population.