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Öğe An animal model of effects of nicotine exposure on endometrial receptivity and embryo implantation in pregnancy(Taylor & Francis Ltd, 2017) Akpak, Yaşam Kemal; Çekmez, Yasemin; Erdoğan Çakır, Aslı; Karaca, Nilay; Batmaz, Gonca; Gülşen, Serdar; Haberal, Esra TuştaşObjective: This study aims at evaluating the endometrial receptivity in uterus of pregnant rats exposed to nicotine via examination of integrin expression by immunohistochemical effect. Methods: In this study, 16 healthy pregnant rats were divided into two groups of control and study groups each comprising eight rats. The rats randomised to study group were given a certain amount of nicotine before and during the pregnancy. Integrin expression was detected in uterus of all rats by immunohistochemical staining. The effect of nicotine exposure on embryo implantation and the endometrial receptivity were immunohistochemically and pathologically evaluated. Results: Comparison of both groups revealed no difference in living, viable foetuses. Intensity and universality of immunohistochemical staining of Integrin 3 for endometrial epithelium and endometrial stroma were detected to be identical between the groups. Conclusion: No immunochemical effect was observed on integrin expression, which is a very important part of receptivity in an animal model created with pregnant rats that were transdermally exposed to nicotine. Our study demonstrated that the harmful effect of nicotine use before and pregnancy on implantation is limited at the level of integrin expression, in a dose-dependent manner and also by considering the method of administration.Öğe Effect of IVF failure on quality of life and emotional status in infertile couples(Elsevier Ireland Ltd., 2016) Karaca, Nilay; Karabulut, Aysun; Özkan, Sevgi; Aktün, Hale; Örengül, Fatma; Yılmaz, Rabiye; Ateş, Seda; Batmaz, GoncaObjective: To investigate the effect of a previous IVF failure on the quality of life and emotional distress, in couples undergoing IVF treatment. Experiencing IVF failure might cause differences on the anxiety depression and quality of life scores of the couples, compared to the ones who were undergoing IVF treatment for the first time. Study design: This study included 64 couples who had previously experienced at least one IVF failure (Group 1) and 56 couples without history of IVF failure (Group 2) in a private Assisted Reproductive Center, Istanbul, Turkey. A sociodemographic data form, the FertiQoL International and Hospital Anxiety (HAD-A) and Depression scale (HAD-D) for evaluating the status of distress, were administered for the study. Result(s): FertiQoL scores were compared between the groups, the environment scale of the quality of life in treatment section was found to be significantly higher in Group 1 compared with Group 2 (p = 0.009). The HAD-A and HAD-D scores did not differ significantly between the groups. Group-variables were investigated using multilevel analysis, the infertility duration and income level were found to have an effect on the subscales of quality of life (p = 0.009 and p = 0.001 respectively) in Group 2. Depression scores were higher in couples with infertility duration of below five years in Group 1 and Group 2 compared to couples with infertility duration of five years or above (MANOVA analysis). The level of education was found to affect the scores of HAD-D in Group 2, but not in Group 1 (p = 0.011). The score of HAD-D was significantly affected by the family type only in Group 2 (p = 0.009); the depression score of the couples living with a nuclear family was found to be higher compared with the couples living in a traditional family (p = 0.021). Conclusion(s): Fertility-specific quality of life scores reveals better results regarding the orientation to the treatment environment in the couples with a previous IVF failure, compared to first IVF cycle couples. Treatment failure does not elevate the level of anxiety, while the effect on depression scores changes according to duration of infertility.Öğe Relation of metabolic syndrome with endometrial pathologies in patients with abnormal uterine bleeding(Taylor and Francis, 2015) Özdemir, Suna; Batmaz, Gonca; Ateş, Seda; Çeli?k, Çetin; İncesu, Feyzanur; Peru, CelalettinPurpose: We aimed to investigate the association of metabolic syndrome and metabolic risk factors with endometrial hyperplasia and carcinoma among women with abnormal uterine bleeding (AUB). Methods: This study included 199 patients who had undergone endometrial curettage due to abnormal uterine bleeding. We divided the patients into two groups according to whether they had an abnormal (n = 53) or normal endometrium (n = 146). Waist circumference, blood pressure, fasting glucose and serum lipid levels were measured and statistically analyzed. The women in each group were matched with regard to mean age, gravidity, parity and menopausal status. Results: We found increased prevalence of metabolic syndrome, diabetes, general and abdominal obesity, hypertension, elevated levels of glucose, total cholesterol and LDL-cholesterol and reduced levels of HDL-cholesterol among women with endometrial carcinoma and hyperplasia. These results were detected particularly in postmenopausal (450 years) women compared to pre-menopausal cases (550 years). All metabolic parameters were similar between hyperplasia and cancer groups. Conclusion: Metabolic syndrome and its components have been shown to have profound impacts on initiation and progession of endometrial pathology, particularly during postmenopausal period.Öğe Soluble TNF-Like weak inducer of apoptosis as a new marker in preeclampsia: A pilot clinical study(Hindawi Ltd, 2016) Yıldırım Kayaoğlu, Zeynep; Sümnü, Abdullah; Bademler, Neslihan; Kılıç, Elif; Sümnü, Gülay; Karadağ, Serhat; Gürsü, Meltem; Özel, Ayşegül; Batmaz, Gonca; Ateş, Seda; Dane, Banu; Öztürk, SavaşIntroduction. All findings of preeclampsia appear as the clinical consequences of diffuse endothelial dysfunction. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) was recently introduced as a TNF related cytokine in various inflammatory and noninflammatory disorders. sTWEAK was found to be related to endothelial dysfunction in patients with chronic kidney disease. In our study we aimed to compare sTWEAK levels in women with preeclampsia to corresponding levels in a healthy pregnant control group. Materials and Methods. The study was undertaken with 33 patients with preeclampsia and 33 normal pregnant women. The concentration of sTWEAK in serum was calculated with an enzyme linked immunosorbent assay (ELISA) kit. Results. Serum creatinine, uric acid, LDH levels, and uPCR were significantly higher in the patient group compared to the control group. sTWEAK levels were significantly lower in preeclamptic patients (332 +/- 144 pg/mL) than in control subjects (412 +/- 166 pg/mL) (p = 0.04). Discussion. Our study demonstrates that sTWEAK is decreased in patients with preeclampsia compared to healthy pregnant women. There is a need for further studies to identify the role of sTWEAK in the pathogenesis of preeclampsia and to determine whether it can be regarded as a predictor of the development of preeclampsia.
