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Öğe Evaluation of the association between matrix metalloproteinase 11 and intervertebral disc disease(Turkish Neurosurgical Society, 2016) Aras, Adem Bozkurt; Güven, Mustafa; Balak, Naci; Ayan, Erdoğan; Uyar Bozkurt, Suheyla; Elmacı, İlhanAIM: The intervertebral disc starts to degenerate when a human being begins to stand and learn to walk. It is known that many extrinsic, intrinsic and genetic factors play a role in disc degeneration. In this study, we examined whether the matrix metalloproteinase 11 might be associated with intervertebral disc degeneration. MATERIAL and METHODS: Fifty-six patients with lumbar disc herniations who were operated at Gortepe Education and Research Hospital, Neurosurgery Clinic between September 2008 and December 2009 were prospectively reviewed. History and complaints were obtained from the case reports. Neuroradiological evaluation was performed with magnetic resonance imaging. Surgical findings of cases were reported in the operation notes. Microscopic posterior hemipartial laminectomy and discectomy were performed in all cases. Degenerated herniated disc material of all cases extracted during surgery was evaluated with immunohistochemical staining in Marmara University, Institute of Neurological Sciences, Pathology Laboratory. RESULTS: Comparing the immunohistochemical staining of cases who were 50 years or younger and cases who were over 50 years old, statistical significance was determined. CONCLUSION: Matrix metalloproteinase 11 has a role in degenerating intervertebral disc disease, but it is not the only factor. Matrix metalloproteinase 11 might be a genetic factor in young-middle aged patients.Öğe Remote cerebral and cerebellar hemorrhage after spinal surgery: A case report and literature review(Ege University Press, 2015) Kakşi, Mustafa; Başaran, Recep; Bölükbaşı, Fatih Han; Balkuv, Ece; Balak, NaciIntroduction: Remote cerebral or cerebellar hemorrhage is a term used to describe hemorrhage that occurs secondary to different surgical procedures in various areas of body. Intracranial hemorrhages that occur after spinal surgeries are extremely rare. In this article, we aimed to present our experience on remote cerebellar and accompanying cerebral hemorrhage. Case: We present a 73 years old male patient complaining from back pain, bilateral radicular pain and neurological claudication. There were spinal stenosis and disc herniations on levels of L4-5, L5-S1 on MRI. We performed a posterior stabilization, surgery for spinal stenosis and disc herniation that lead to dural defect. We repaired dura and formed a fibrin barrier. Postoperatively, the patient developed a hemiparesis (3/5) on his right side. On CT scan, left parietal and right cerebellar intraparenchymal hemorrhage has been detected. We performed a total evacuation of the hematoma. Conclusion: It should be remembered that during or following spinal surgeries remote infratentorial and accompanying supratentorial hemorrhages can occur due to cerebrospinal fluid leakages, possibly in elderly patients. Early and definite diagnosis is the most precious step for treatment.











