Yazar "Babademez, Mehmet Ali" seçeneğine göre listele

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    Evaluation of the effects of Covid-19 on cochleovestibular system with audiovestibular tests
    (2024) Bozdemir, Kazım; Ersoy Çallıoğlu, Elif; İslamoğlu, Yüce; Ercan, Mehmet Kadir; Eser, Fatma; Özdem, Birsen; Kıraç, Arda; Bayazıt, Dilara; Güner, Rahmet; Babademez, Mehmet Ali
    Purpose: The purpose of the present study was to investigate the effects of COVID-19 on audiovestibular system with Transiently Evoked Distortion Otoacoustic Emissions (TOAE), Distortion Product Otoacoustic Emissions (DPOAE), video head impulse test (vHIT) and caloric test. Methods: Audiovestibular findings of 24 patients with moderate/severe COVID-19 and 24 healthy controls were compared using pure tone audiometry, tympanometry, TOAE, DPOAE, caloric test, and vHIT. Results: On audiometry, the pure tone averages of the COVID-19 patients were higher than the controls (P =.038). The TEOAE amplitudes at 4000 and 5000 Hz (P =.006 and P <.01), and DPOAE amplitudes at 3000, 6000, and 8000 Hz (P <.001, P =.003 and P <.001) were significantly lower in COVID-19 patients compared to the controls. On vestibular tests, there was no significant difference between the caloric test results of the patients and the controls (P >.05). On vHIT testing, amplitudes of right semicircular canal was found to be significantly lower in COVID-19 group compared to the control group (P =.008). Conclusion: COVID-19 may affect inner ear functions causing a subtle damage in the outer hair cells and lateral semicircular canals. It must be kept in mind that COVID-19 may cause cochleovestibular problems.
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    Therapeutic effects of metformin for noise induced hearing loss
    (W.B. Saunders, 2020) Gedik, Özge; Do?an, Remzi; Babademez, Mehmet Ali; Karataş, Ersin; Aydın, Mehmet Şerif; Koçyi?it, Abdurrahim; Eşrefo?lu, Mukaddes; Özturan, Orhan
    Objective: This study aimed to investigate the healing effect of metformin on noise induced hearing loss (NIHL) by measuring audiological, biochemical and histological parameters.Materials and methods: 32 rats were divided into four groups (Group 1: Noise, Group 2: Noise + Metformin, Grup 3: Metformin, Grup 4: Control). Broadband noise was applied to Group 1 and Group 2 after basal measurements. Measuring audiological (distortion product otoacoustic emission (DPOAE) and Auditory Brainstem Response (ABR)), biochemical (total antioxidant status (TAS), total oxidant status (TOS), oxidative status index (OSI), DNA damage, IL-1 beta, IL-6, TNF alfa, HSF-1 and COX-2) and histological parameters.Results: Group 2 had significant decreases in ABR thresholds on day 7 and day 14 compared to day 1. DPOAE values of Group 2 on the 7th and 14th days were significantly higher than the post-noise levels. DNA damage, TOS and OSI values of Group 1 were significantly higher than the other groups. The Cox-2 value of Group 1 was higher than all other groups. The HSF-1 value of Group 2 was significantly higher than that of Group 1. In terms of IL-1 Beta, IL-6 and TNF-alpha values, there was no significant difference between groups 2, 3 and 4 and these values were significantly lower than group 1. In histopathological results of our study, no significant difference was found between the groups being exposed to noise and the control group.Conclusion: This study showed that early period of Metformin treatment has therapeutic effect on NIHL.
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    Thiol/disulphide homeostasis in Bell's palsy as a novel pathogenetic marker
    (Wiley, 2017) Babademez, Mehmet Ali; Gül, Fatih; Kale, Hayati; Müderris, Togay; Bayazıt, Yıldırım; Ergin, Merve; Erel, Özcan; Kiriş, Muzaffer
    Objectives: The aim of this study was to investigate the relationship between Bell's palsy and a novel oxidative stress parameter, thiol/disulphide homeostasis. Design: A prospective study evaluating oxidative stress in Bell's palsy. Setting: This research took place in the department of Otorhinolaryngology, Ataturk Training and Research Hospital. Participants: Totally, 77 patients with Bell's palsy and 38 healthy controls were included in this study. Main outcome measures: The blood levels of total and native thiol and disulphide activity were assessed, and their levels were compared in the patients and controls. Results: There were statistically significant differences between the patients and controls regarding thiol/disulphide parameters. The mean native thiol and total thiol were significantly lower and disulphide levels were higher in the Bell's palsy than controls. On binary logistic regression analysis, the created model showed 45.3% variation. The cutoff value was 18.95 for disulphides. Conclusion: Native and total thiol levels were low in the Bell's palsy. This metabolic disturbance may have a role in the pathogenesis of Bell's palsy.