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  • Küçük Resim
    Öğe
    Effects of erythropoietin on spontaneous and oxytocin induced myometrial contractions in the nonpregnant rat
    (Verduci Publisher, 2017) Tuğ, Niyazi; Ayvacı Tasan, Habibe; Sargın, Mehmet Akif; Doğan Taymur, Bilge; Ayar, Ahmet; Kılıç, Ertuğrul; Yılmaz, Bayram
    OBJECTIVE: Erythropoietin (EPO) is a glycoprotein hormone that regulates erythropoiesis. EPO activity has also been detected in a variety of tissue including the nervous system, and female and male reproductive organs. It has been shown that EPO causes relaxation in vascular smooth muscle. In the present study, we have investigated effects of EPO on spontaneous and oxytocin-induced contractions of non-pregnant rat myometrium. MATERIALS AND METHODS: Myometrial stripes were obtained from adult Wistar rats at the oestrous stage. The samples were placed in an isolated organ chamber under physiological conditions and 1 g passive tension. Epoetin beta (rEPO) was added cumulatively at 0.1, 1 and 10 IU/ml concentrations to the myometrial samples showing regular spontaneous contractions for periods of 30 min. Frequency and amplitude of contractions were electrophysiologically recorded and analyzed by using a BIOPAC data acquisition system. RESULTS: rEPO inhibited both area under curve and frequency of spontaneous contractions (ANOVA, n1, 2 = 9, f1 = 20.938, f2 = 20.492, p1,2 = 0.000). The inhibitory effect was insignificant at 0.1 mIU/ml rEPO level (Tukey HSD, p1 = 0.051, p2 = 0.581). In the oxytocin treated myometrial samples, a single dose of 1 IU/ml rEPO was studied. The area under curve and frequency values of these samples were inhibited by rEPO (Student's t-test, n = 9, t1 = 4.776, p1 = 0.000; t2 = 2.835, p2 = 0.012, respectively). CONCLUSIONS: rEPO inhibited spontaneous and oxytocin-induced rat myometrial contractions at 1 and 10 IU/ml concentrations. It appeared that the effect was dose-dependent.
  • Küçük Resim
    Öğe
    Strategies for development, management and funding of scientific projects
    (Wiley-Blackwell, 2015) Öztürk, Gürkan; Ayar, Ahmet; Gözay, Ozge; Yılmaz, Bayram
    In the academic environment the number of scientists is continuously increasing so the number of scientific projects seeking funding. This competition is at a higher level than before. Attempts for obtaining funding and increasing number of project applications make evaluation and distribution of funding a harder task. These projects are cross-evaluated at scientific panels of reviewers from multidisciplinary areas. In the recent years, amount of funding provided by TÜBİTAK and relavant government agencies has increased. European Union funding has also increased and diversified. Although project culture has significantly progressed among researchers, there are still structural design and technical mistakes in submitted proposals that result in failure. There are various programs in the framework of Horizon 2020 that are available to applications of Turkish researchers. Finding international project partner and attending to several technical details are of critical importance, for which TÜBİTAK offers advisory and technical support.