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    Comparison of the effects of two different analgesics on bone regeneration during mandibular distraction osteogenesis
    (Lippincott Williams and Wilkins, 2019) Alakuş Sabuncuoğlu, Fidan; Erşahan, Şeyda; Amasyalı, Mihri; Avunduk, Mustafa Cihat
    Introduction: Mandibular distraction osteogenesis (DO) is frequently used in the management of bone defects and craniofacial deformities, with analgesics commonly administered to relieve acute postoperative pain. This experimental animal study investigated the effects of 2 analgesics, acetaminophen and acemetacin, on bone regeneration after DO. Materials and methods: This study was conducted with 14 mature male New Zealand rabbits (2.8-32 kg) randomized into 2 groups of 7. Mandibular osteotomies were performed under optimal operating conditions, and a custom-made distractor was applied to the mandible of each subject, with distraction initiated after a 5-day latency period at a rate of 1.0 mm/d (2 x 0.5 mm/d) for 10 days. Analgesics were administered via oral gavage during the latency period and for the first 5 days of the distraction period for 10 days in total, with group I receiving acetaminophen (200 mg/kg/d) and group II receiving acemetacin (5 mg/kg/d). Subjects were sacrificed and their mandibles dissected at the end of 4 weeks postoperatively. Bone mineral density (BMD) and bone mineral content (BMC) were measured using dual-energy X-ray absorptiometry (DEXA), and histomorphometric analysiswas performed to evaluate the quality of newly formed bone. Paired group comparisons of non-normally distributed numerical variables were made using the Mann-Whitney U test, with a P value of <0.05 considered statistically significant. Results: No significant differences in BMC and BMD values of intact bone, newly formed bone, or bone around the pin site were observed between the 2 groups. Histometric analysis also indicated acetaminophen and acemetacin to have similar effects on bone regeneration during distraction. Conclusion: Acemetacin may be an alternative to acetaminophen for treating pain associated with DO, given the similarities in the effects of the 2 analgesics on bone regeneration. However, this finding should be supported by further experimental and human studies.
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    Malignant triton tumor of the oral cavity: A rare occurrence
    (Springer Verlag, 2012) Seyhan, Nevra; Tosun, Zekeriya; Avunduk, Mustafa Cihat; Savacı, Nedim
    Malignant peripheral nerve sheath tumors (MPNST) arise fromSchwann cells or within existing neurofibromas and, as agroup, account for approximately 5–10% of all soft tissuesarcomas [1]. Although MPNST may consist of tissues such asglandular epithelium, squamous cell, cartilage, or bones, thosewhich possess only skeletal muscle differentiation are referredto as malignant triton tumor (MTT). The tumor consists of twocell lines, rabdomyoblasts and Schwann cells.
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    The effect of human amniotic fluid on mandibular distraction osteogenesis
    (Churchill Livingstone, 2015) Gökçe, Sıla Mermut; Karaçaylı, Ümit; Nalçaci, Ruhi; Avunduk, Mustafa Cihat; Özgöçmen, Meltem; Karaşahin, Kazım Emre; Gökçe, Hasan Suat
    The aim of this study was to evaluate the effects of local administration of human amniotic fluid (HAF) on newly formed bone obtained by mandibular distraction osteogenesis (DO) with histomorphometry. A unilateral mandibular osteotomy at the left corpus was performed in 32 adult male rabbits. After a 5-day latency period, the left mandibles were lengthened by mandibular DO over 5 days, at a rate of 1 mm/day, via a custom-made distractor. After the distraction, the rabbits were divided randomly into four groups: 0.3 ml HAF was injected into the distraction gap followed by 21 (group 1) or 45 (group 2) days of consolidation; or 0.3 ml normal saline (NS) was administered followed by 21 (group 3) or 45 (group 4) days of consolidation. Mandibles were removed at the end of the consolidation period and investigated histomorphometrically. The newly formed bone area (NFBA) and number of fibroblasts increased significantly in the HAF groups compared to the NS groups (NFBA: group 1 vs. group 3, P < 0.05; group 2 vs. group 4, P < 0.01; fibroblasts: group 1 vs. group 3, and group 2 vs. group 4, P < 0.05), and also in both 45-day consolidation groups compared to the 21-day consolidation groups (NFBA: group 1 vs. group 2, and group 3 vs. group 4, P < 0.001; fibroblasts: group 1 vs. group 2, and group 3 vs. group 4, P < 0.01). Additionally, the numbers of osteoblasts and capillaries were increased significantly at 45 days of consolidation compared to 21 days in both the HAF and NS groups (osteoblasts: group 1 vs. group 2, P < 0.01; group 3 vs. group 4, P < 0.05; capillaries: group 1 vs. group 2, and group 3 vs. group 4, P < 0.01). Histomorphometric analysis demonstrated that local HAF administration effectively accelerated bone formation. Thus, a HAF injection procedure could improve new bone formation around the bone in maxillofacial operations such as DO.