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    Effect of proton pump inhibitor use on Helicobacter pylori positivity and atrial fibrillation
    (Dove Medical Press, 2015) Atay, Kadri; Kaya, Ömer
    We read with interest the report by Wang et al regarding the association between Helicobacter pylori infection and atrial fibrillation.1 One of our concerns about this well designed study is the lack of reporting of proton pump inhibitor (PPI) use in the patients and controls. It is well known that use of PPIs influences the results of some tests for H. pylori, including the urea breath test, which the authors used in their study. Notably, the frequency of H. pylori antibody positivity was similar between all three groups while H. pylori infection seems to be significantly more common in subjects with long-standing atrial fibrillation. More frequent use of PPIs may potentially explain the lower frequency of H. pylori positivity in the control group and short-term atrial fibrillation group. Further, there are some recent reports indicating a protective effect of PPIs on the risk of atrial fibrillation, especially in people with gastroesophageal reflux disease.2 In conclusion, use of PPIs may have influenced some of the test results in this study, including the risk of atrial fibrillation.
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    The effect of Helicobacter pylori eradication on arterial stiffness and qt dispersion
    (Scientific Publishers of India, 2017) Kaya, Ömer; Tufan, Fatih; Başar, Rafet; Akpınar, Timur Selçuk; Atay, Kadri; Alpay, Nadir; Nas, Kamil; Illyes, Miklos; Ecder, Süleyman Tevfik
    The association of Helicobacter pylori (HP) with cardiovascular disease remain inconclusive. Studies regarding arterial-stiffness (AS) in patients with HP infection are limited. We aimed to evaluate AS and QTc dispersion in patients with HP infection and the effect of eradication treatment on these outcomes. We enrolled patients with HP infection and healthy subjects. We measured AS and QTc dispersion in the baseline visit and after eradication treatment. We compared baseline measurements between the patients and controls. We compared baseline and follow-up variables to observe the effect of eradication treatment on AS and QTc dispersion. Baseline characteristics were similar between the groups. There was no significant difference in AS measures between the groups. QTc dispersion was significantly higher in the HP group compared with controls. After eradication, QTc dispersion tended to normalize. There was also a statistically significant improvement in augmentation index and a tendency towards improvement in pulse wave velocity. The findings of this study indicate possible influence of HP infection on ventricular repolarization and a potential benefit of eradication on ventricular repolarization and measures of arterial stiffness.