Yazar "Api, Murat" seçeneğine göre listele
Listeleniyor 1 - 20 / 20
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Association between FVL G1691A, FII G20210A, and MTHFR C677T and A1298C polymorphisms and Turkish women with recurrent pregnancy loss(Medical Association of Zenica-Doboj Canton, 2020) Yengel, İrem; Yorulmaz, Tülay; Api, MuratAim Recurrent pregnancy loss (RPL) poses a challenge in reproductive medicine because the etiology is often unknown. Here we investigated the frequency of mutations in the Factor V Leiden (FVL), prothrombin (FII), and methylene tetrahydrofolate reductase (MTHFR) genes in women with RPL and healthy women. Methods Blood samples were obtained from patients with ?2 consecutive pregnancy losses and no identifiable etiology before 12 weeks of pregnancy (n=145). The control group comprised 105 age-matched women with ?2 live births. Results The frequency of homozygotes for FVL 1691AA was 15 (10.3%) in patients and three (2.86%) in controls (p=0.073), while for FII 20210AA it was eight (5.5%) and one (0.9%), respectively (p=0.055). For two polymorphisms in MTHFR, genotype frequencies of 89 (61.4%) were found in patients and 55 (52.4%) in controls for 677TT (p=0.322), and 89 (61.4%) and 62 (59%) for 1298CC, respectively (p=0.810). Conclusion Despite a trend towards significance for FII G20210A, no significant differences in genotype frequencies of these polymorphisms between patients and controls was found. No evidence of the role of FVL G1691A, MTHFR C677T, and MTHFR A1298C in RPL in our Turkish cohort was found; however, further investigation of FII as a culprit gene in RPL is warranted.Öğe Comparison of the effectiveness of topical silicone gel and corticosteroid cream on the pfannenstiel scar prevention - a randomized controlled trial(Via Medica, 2017) Meşeci, Elif; Kayataş, Semra; Api, Murat; Boza, Ayşen; Çıkman, Muzaffer SeyhanObjectives:To compare the effects of topical silicone gel and corticosteroid cream for preventing hypertrophic scar and keloid formation following Pfannenstiel incisions. Material and methods: Fifty patients operated for benign gynecological diseases through primary Pfannenstiel incision were included. The wounds were randomly allocated to the treatment and control arms. In the treatment arm, the wounds were divided into two halves; one was treated with silicone gel and the other with methylprednisolone cream. No treatment was administered to the control group. Scars using the modified Vancouver Scar Scale (MVSS), patient satisfaction, and side effects were evaluated before and after (3rd month when treatment discontinued and 6th month) the treatment. Results:Thirty-nine patients (21 patients in the treatment group and 18 patients in the control group) completed the study. Intragroup comparisons of the 3rd month and 6th month scores of the MVSS revealed that the scores of all parameters (height, pigmentation, vascularity, pliability, and total MVSS score) significantly decreased at the 6th month evaluation as compared with the 3rd month evaluation in all groups (control, silicone, and methylprednisolone groups). Multiple group comparisons at the 6th month revealed that the most prominent improvements occurred in the methylprednisolone group in all MVSS parameters as compared with the control group and in the height, vascularity, and pigmentation parameters as compared with the silicone group. No side effects were experienced by the patients with either treatment and patient satisfaction was higher in the methylprednisolone group. Conclusion: The use of topical methylprednisolone cream in fresh wounds at the postoperative early period appears to be promising.Öğe Correlation between the level of education and the adequacy of cervical excisional procedures in patients with cervical preinvasive lesions(BMJ Publishing Group, 2019) Ceylan, Yasemin; Api, Murat; Kabaca Kocakuşak, Canan; Keleş, Erhan; Akış, Serkan; Purut, Yunus Emre; Giray, Burcu; Güray Uzun, Mine[Abstract Not Available]Öğe Could the female-to-male transgender population be donor candidates for uterus transplantation?(Galenos Yayıncılık, 2017) Api, Murat; Boza, Ayşen; Ceyhan, MehmetObjective: To evaluate the eligibility of female-to-male (FtM) transgender people as donor candidates with regard to histologic, surgical, and social aspects. Materials and Methods: In this prospective cohort study, 31 FtM transgender people underwent standard hysterectomy and bilateral salpingo-oophorectomy for gender reassignment upon their request. The pelvic viscera of the transgender people was intraoperatively observed and the histology of the removed uteri were evaluated for fertility capacity and procurement surgery. A questionnaire was administered to explore their attitude towards uterus donation. Results: The mean +/- standard deviation age was 28.5 +/- 5 years. The median duration of testosterone supplementation was 2.4 years; therefore, they all had irregular menstrual periods during this therapy. None had any previous abdominal surgery or additional morbidity. The mean uterine volume was 138 +/- 48 cm(3). No adenomyosis, endometriosis, polyps, adhesions or uterine anomalies were either observed or reported. Endometrial histology was reported as proliferative (58%), atrophic (29%), and secretory (13%) pattern. Of the 31 transgender people, 30 (96.7%) had a positive attitude; only one had no opinion at the beginning. After detailed information about the procedure was given, 26 (84%) still wanted to volunteer for donation, but 4 (12%) changed their opinion to negative (p=0.12, McNemar test). Conclusion: The proposal of the FtM transgender population as uterus donor is a hypothetical model that has not been experienced before. Nevertheless, our experience revealed that the FtM transgender population would be good candidates socially, legally, and biologically.Öğe Does HPV type affect the rate of positive surgical margin after cervical cone excision?(BMJ Publishing Group, 2019) Purut, Yunus Emre; Akış, Serkan; Keleş, Erhan; Api, Murat; Kabaca Kocakuşak, Canan; Ceylan, Yasemin; Giray, Burcu; Uzun, Mine[Abstract Not Available]Öğe Effect of human papillomavirus subtype on the rate of positive surgical margin after cervical conization(SAGE Publications Inc., 2023) Purut, Yunus Emre; Giray, Burak; Akış, Serkan; Keleş Peker, Esra; Babayeva, Gülçin; Kabaca, Canan; Api, MuratObjective. Human papillomavirus (HPV) infection is a risk factor for cervical carcinoma. Over 100 types of HPV have been identified. The excisional procedures are recommended for women with high-grade cervical intraepithelial neoplasia. Surgical margin status is an important predictor of the risk of relapse. The aim of the current study was to evaluate whether HPV genotype is a predictive factor of positive surgical margin after cervical cone excision. Materials and Methods. The records of 448 HPV-infected patients who underwent loop electrosurgical excision or cold knife conization at a tertiary gynecological cancer center were retrospectively reviewed. The patients were divided into 6 groups according to HPV positivity: HPV 16 only, HPV 18 only, HPV 16/18, other high-risk HPV (hrHPV), HPV 16/hrHPV, and HPV 18/hrHPV. Results. There was no significant difference between the HPV groups in terms of age, parity, menopausal status, endocervical canal involvement, conization method, and the rates of positive margin (P = .15, P = .49, P = .07, P = .20, P = .24, P = .39, respectively). Conclusion. The results show that HPV subtypes might not be associated with endocervical canal involvement and the rates of positive margin. In addition, margin status was not related to the conization method and the number of excised cervical tissue.Öğe Gonadotropinlerle ovulasyon indüksiyonu ve intrauterin inseminasyon yapılan açıklanmayan infertil çiftlerde hcg günü endometrial kalınlık ve paterninin tedavi başarısına etkisi(Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, 2018) Erol Türkyılmaz, Şebnem; Türkyılmaz, Gürcan; Api, MuratAmaç: Kontrollü ovulasyon indüksiyonu ve intrauterin inseminasyon (OI-IUI) tüm dünyada infertil çiftlerde ilk basamak tedavi olarak kullanılmaktadır. Bu çalışmada OI-IUI yapılan nedeni belirlenemeyen infertilite olgularında HCG günü değerlendirilen endometrial kalınlık ve paternin tedavi başarısına etkisini inceledik. Gereçler ve Yöntem: Bu çalışmada Şubat 2013-Eylül 2013 tarihleri arasında nedeni belirlenemeyen infertilite tanısı alan 101 çift ve132 IUI siklusu prospektif olarak incelendi. Bulgular: 132 siklusta 22 gebelik elde edildi ve siklus başına gebelik oranı %16.6 hasta başına gebelik oranı %21.7 olarak hesaplandı. Gebelik pozitif ve negatif olan grupta kullanılan FSH dozu, stimülasyon süresi, bazal FSH, bazal E2, TPMSS, IUI siklus sayısı, folikül çapı arasında anlamlı farklılık saptanmadı. Gebelik pozitif olan grupta infertilite süresi 2.1±1.4 yıl gebelik negatif olan grupta 4.1±2.3 yıldı ve bu fark anlamlı olarak daha kısaydı (p < 0,05). Gebelik pozitif olan grupta antral folikül sayısı ve HCG günü folikül sayısı gebelik negatif olan gruptan anlamlı (p < 0.05) olarak daha yüksekti. HCG günü yapılan endometrial değerlendirmede gebelik elde edilen grupta 9.8±1.1 mm, gebelik elde edilemeyen grupta ise 9.6±3.5 mm ölçüldü ve endometrial kalınlığın veya endometrium paterninin her iki grup arasında anlamlı farklılık göstermediği görüldü. Sonuç: İnfertilite tedavisinde OI-IUI uygulanan hastalarda HCG günü ölçülen endometrial kalınlık ve endometrial paternin gebelik oranlarını etkilemediği görüldü.Öğe Interobserver variability of Eastern Cooperative Oncology Group (ECOG) performance status in gynecologic oncology patient(BMJ Publishing Group, 2019) Api, Murat; Keleş, Erhan; Akış, Serkan; Purut, Yunus Emre; Ceylan, Yasemin[Abstract Not Available]Öğe Is the depth of cone related to the endocervical glandular involvement in patients who underwent loop electrosurgical excision procedure or cold knife conization?(BMJ Publishing Group, 2019) Akış, Serkan; Purut, Yunus Emre; Keleş, Erhan; Api, Murat; Kabaca Kocakuşak, Canan; Giray, Burcu; Ceylan, Yasemin; Güray Uzun, Mine[Abstract Not Available]Öğe Laparoscopic management of primary vaginal clear cell carcinoma in a woman without diethylstilbestrol exposure(BMJ Publishing Group, 2018) Aykanat, Yeliz; Api, Murat[Abstract Not Available]Öğe Laparoscopic management of uterine tumors resembling ovarian sex cord tumors - Pregnancy, recurrence after fertility sparing surgery and literature review(Bmj Publishing Group, 2018) Api, Murat; Ceylan, Yasemin[Abstract Not Available]Öğe Laparoscopic repair of ureter damaged during laparoscopic hysterectomy: Presentation of two cases(Galenos Yayıncılık, 2017) Api, Murat; Boza, Ayşen; Kayataş, Semra; Boza, BarışUreter injuries are uncommon but dreaded complications in gynecologic surgery and a frequent cause of conversion to laparotomy. Recently, a few papers reported the repair of gynecologic ureteral injuries using laparoscopy with encouraging results. In these case reports, we aimed to present two laparoscopically repaired ureter injuries during total laparoscopic hysterectomies (TLH). In the first case, the ureter was transected during the dissection of the cardinal ligament, approximately 7 to 8 cm distal to the ureterovesical junction (UVJ), and in the second case, it was damaged approximately 10 cm distal to the UVJ. Both transections were identified during surgery. The injured ureter was repaired without converting to laparotomy or additional trocar insertion. Ureteroureterostomy was performed in both cases uneventfully. Although ureteric injury is a rare complication during TLH, it can be managed by the same surgeon laparoscopically during the same procedure.Öğe Management of ovulation induction and intrauterine insemination in infertile patients with hypogonadotropic hypogonadism(Elsevier, 2019) Kıyak, Hüseyin; Bulut, Berk; Karacan, Tolga; Özyürek, Eser; Gedikbaşı, Ali; Api, MuratAim: To investigate the effectiveness of ovulation induction and intrauterine insemination (OI + IUI) in female patients with hypogonadotropic hypogonadism (HH), and to compare the outcomes of different stimulation protocols and cycle characteristics. Material and methods: The outcomes of OI + IUI treatments in patients with HH diagnosed between 2010 and 2018 were retrospectively evaluated. Cycles using recombinant (rec) luteinizing hormone (LH) or human menopausal gonadotropin (hMG) as LH sources were compared with each other. The cycle characteristics and pregnancy rates of the first cycles were compared with those of the second cycles in patients who underwent 2 or more cycles. Results: Of 104 patients diagnosed with World Health Organization type 1 anovulation, 99 were treated with hMG or rec LH + rec follicle-stimulating hormone (FSH) in a total of 220 cycles. The mean age of the study patients was 27.8 +/- 4.6 years (range, 19-39 years). Rec FSH + rec LH was given in 37 cycles, and hMG was used in 183 cycles. The hormone values were as follows: FSH, 1.4 +/- 1.6 mIU/mL; LH, 0.7 +/- 1.2 mIU/mL; oestradiol, 13 (15.8 +/- 12.0) pg/mL; and anti-Mullerian hormone, 2.1 (2.6 +/- 1.2) ng/mL. A dominant follicle was observed in 85.7% of the first cycles and in 86.2% of the second cycles. The treatment lasted 17.2 +/- 5.0 and 15.5 +/- 3.8 days until the human chorionic gonadotropin (hCG) administration day in the first and second cycles, respectively, and the difference was statistically significant (p < 0.05). The cycle cancellation rate was 8.1% (n = 3) in cycles done using rec gonadotropins and 29% (n = 53) in patients stimulated with hMG, and the difference was statistically significant (p < 0.05). The pregnancy rates were 12.7% and 28.3% per cycle and per patient, respectively. The pregnancy rate in hCG-triggered patients (successful stimulation) was 17.1% per cycle in all patients. Conclusion: OI with gonadotropins and IUI is a safe, efficient, and relatively cost-effective treatment option in patients with HH, yielding reasonable pregnancy rates per cycle and per patient. The use of rec FSH + rec LH facilitates cycle management but does not positively contribute to pregnancy rates and is more expensive than some other feasible options. (C) 2019 Elsevier Masson SAS. All rights reserved.Öğe Predictors of gas passage time interval at postoperative period in gynecologic oncologic surgery: Is drainage necessary?(BMJ Publishing Group, 2019) Api, Murat; Akış, Serkan; Purut, Yunus Emre; Keleş, Erhan; Ceylan, Yasemin; Kabaca Kocakuşak, Canan; Güray Uzun, Mine; Giray, Burcu[Abstract Not Available]Öğe Recurrent endometrioma in infertile patients has worse outcome than primary endometrioma in response to controlled ovarian hyperstimulation and intrauterine insemination(Science Printers and Publishers Inc., 2019) Kıyak, Hüseyin; Karacan, Tolga; Bulut, Berk; Özyürek, Eser; Gedikbaşı, Ali; Api, MuratObjective: To investigate the difference in the effectiveness of controlled ovarian hyperstimulation and intrauterine insemination (COH + IUI) on pregnancy rates in patients with primary and recurrent endometriomas. Study Design: Multicenter, retrospective cohort study done in 3 tertiary referral centers. Included in the study were (1) primary infertility patients with endometriomas who had no other probable cause for infertility, (2) those who underwent 2 cycles of COH + IUI, provid- ed the sperm test was nor- mal, (3) those who had at least 1 patent fallopian tube, and (4) those whose ovarian reserve was normal with ovulatory cycles. Therapy for COH was hMG (menotropin) or recombinant follicle-stimulating hormone (follitropin alfa, beta) at 75 IU/d starting from day 3. Trigger was done by 5,000-10,000 human chorionic gonadotropin or choriogonadotropin alfa 250 mu g/0.5 mL when the dominant follicle size reached 18 mm. Results: The ongoing pregnancy rates in patients with primary endometrioma were 14.4% per patient and 8.06% per cycle. In patients with recurrent endometrioma, the ongoing pregnancy rates were 6.06% per patient and 3.4% per cycle. Ongoing pregnancy rates were significantly higher in patients with primary endometrioma than in recurrent endometrioma patients. CONCLUSION: COH + IUI may be recommended even before surgery for couples with primary endometriomas when there is no other infertility factor. COH + IUI treatment is not recommended for recurrent endometrioma patients.Öğe Significance of CA-125 levels in uterine papillary serous cancer(BMJ Publishing Group, 2019) Keleş, Erhan; Akış, Serkan; Purut, Yunus Emre; Api, Murat; Kabaca Kocakuşak, Canan; Ceylan, Yasemin; Giray, Burcu; Güray Uzun, Mine[Abstract Not Available]Öğe The efficacy of laparoscopic presacral neurectomy in dysmenorrhea: Is it related to the amount of excised neural tissue?(2017) Api, Murat; Boza, Ayşen; Ceyhan, Mehmet; Kaygusuz, Ecmel; Yavuz, Hülya; Api, OluşObjective: To assess the correlation between the number of excised neural fibers and degree of pain relief following laparoscopic presacral neurectomy (LPSN).Materials and Methods: In this before and after study, 20 patients with severe midline dysmenorrhea [Visual Analogue Scale (VAS) >80 mm] unresponsive to medical therapy were consecutively enrolled. All patients underwent LPSN. The superior hypogastric plexus was excised and sent for histologic confirmation. Two pathologists counted the number of neural fibers in the surgically removed tissue. VAS was used for pain assessment before and 2nd, 3rd, 6th, and 12th months after the operations.Results: Out of the initial 20 patients undergoing LPSN, eight were excluded from the final analysis due to intraoperative diagnosis of endometriosis; therefore, the remaining 12 patients were evaluated. The pain scores significantly decreased at each follow-up visit compared with the preoperative period (p=0.002). The pathologists, who were blinded, reported the median (minimum-maximum) neural fiber count as 46 and 47 . No significant correlation was demonstrated between the number of excised neural fibers and the amount of pain relief following LPSN. Conclusion: LPSN is an effective surgical procedure to control primary dysmenorrhea. Our preliminary results revealed that the degree of pain relief in cases of severe midline dysmenorrhea was not related to the amount of excised neural tissue in LPSN.Öğe The rate of HPV and smear positivity in the follow-up period of patients that underwent cervical excisional procedures(BMJ Publishing Group, 2019) Purut, Yunus Emre; Keleş, Erhan; Akış, Serkan; Api, Murat; Kabaca Kocakuşak, Canan; Ceylan, Yasemin; Giray, Burcu; Güray Uzun, Mine[Abstract Not Available]Öğe The role of multiple high-risk human papillomavirus infections for cervical biopsies and findings in colposcopic procedures(Galenos Publishing House, 2023) Akış, Serkan; Öztürk, Uğur Kemal; Keleş, Esra; Alınca, Cihat Murat; Kabaca, Canan; Api, MuratObjective: The clinical outcome of high-risk HPV (hr-HPV) infection varies according to genotype(s). Patients may harbor either one single hr-HPV (s-HPV) or multiple HPV (m-HPV) genotypes. Recently, the relationship between m-HPV infections and high-grade dysplasia has been investigated, and controversial results have been obtained. Therefore, the clinical significance of m-HPV is not clear. This study aimed to evaluate which group is associated with higher grade dysplasia by analyzing colposcopic punch biopsies. Material and Methods: A total of 690 patients who were scheduled for a diagnostic excisional procedure between April 2016 and January 2019 due to the detection of high-grade cervical intraepithelial neoplasia (CIN 2/3) in colposcopy were included. Patients who were not scheduled for colposcopic examination or cervical punch biopsy, or who were scheduled for an excisional procedure due to smear-biopsy incompatibility or persistent low-grade dysplasia were excluded. Patients with a negative HPV test and an unknown HPV genotype were also excluded. Results: Among the patients scheduled for excision (n=404), 74.5% had a s-HPV and 25.5% had a m-HPV infection. The proportion of CIN 1, 2 and 3 per patient in the m-HPV group was significantly higher than the s-HPV group (p=0.017). When this analysis was made for the number of CIN 2+3 per patient in the s-HPV and m-HPV groups, it was 1.29 (389/301) and 1.36 (140/103), respectively, and no difference was found (p=0.491). Conclusion: Patients in the m-HPV group, who underwent more colposcopic cervical biopsies, had higher numbers of CIN lesions, regardless of age and cytology results.Öğe Validation of Turkish version of Eastern Cooperative Oncology Group Performance Status (ECOG-PS) for gynecologic oncology patients(BMJ Publishing Group, 2019) Api, Murat; Purut, Yunus Emre; Akış, Serkan; Keleş, Erhan; Ceylan, Yasemin; Kabaca Kocakuşak, Canan; Giray, Burcu; Güray Uzun, Mine[Abstract Not Available]
