Yazar "Alper, Fatih" seçeneğine göre listele
Listeleniyor 1 - 9 / 9
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A novel approach to contrast-induced nephrotoxicity: The melatonergic agent agomelatine(British Inst Radiology, 2016) Karaman, Adem; Diyarbakır, Büşra; Durur Subaşı, Irmak; Köse, Duygu; Özbek Bilgin, Aslı; Topçu, Atilla; Gündoğdu, Cemal; Durur Karakaya, Afak; Bayraktutan, Zafer; Alper, FatihObjective: To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). The drug's action on the antioxidant system and proinflammatory cytokines, superoxide dismutase (SOD) activity, levels of glutathione (GSH) and malondialdehyde (MDA) and the gene expression of interleukin-6 (IL-6), tumour necrosis factor (TNF)-alpha and nuclear factor kappa B (NF-kappa B) was measured. Tubular necrosis and hyaline and haemorrhagic casts were also histopathologically evaluated. Methods: The institutional ethics and local animal care committees approved the study. Eight groups of six rats were put on the following drug regimens: Group 1: healthy controls, Group 2: GLY (glycerol), Group 3: CM (contrast media-iohexol 10 ml kg(-1)), Group 4: GLY+CM, Group 5: CM+AGO20 (agomelatine 20 mg kg(-1)), Group 6: GLY+CM1AGO20, Group 7: CM1AGO40 (agomelatine 40 mg kg(-1)) and Group 8: GLY+CM+AGO40. The groups were evaluated by one-way analysis of variance and Duncan's multiple comparison test. Results: Agomelatine administration significantly improved the serum levels of blood urea nitrogen (BUN) and creatinine, SOD activity, GSH and MDA. The use of agomelatine had substantial downregulatory consequences on TNF-alpha, NF-kappa B and IL-6 messenger RNA levels. Mild-to-severe hyaline and haemorrhagic casts and tubular necrosis were observed in all groups, except in the healthy group. The histopathological scores were better in the agomelatine treatment groups. Conclusion: Agomelatine has nephroprotective effects against CIN in rats. This effect can be attributed to its properties of reducing oxidative stress and inhibiting the secretion of proinflammatory cytokines (NF-kappa B, TNF-alpha and IL-6). Advances in knowledge: CIN is one of the most important adverse effects of radiological procedures. Renal failure, diabetes, malignancy, old age and nonsteroidal anti-inflammatory drug use pose the risk of CIN in patients. Several clinical studies have investigated ways to avoid CIN. Theophylline/aminophylline, statins, ascorbic acid and iloprost have been suggested for this purpose. Agomelatine is one of the melatonin ligands and is used for affective disorders and has antioxidant features. In this study, we hypothesized that agomelatine could have nephroprotective, antioxidant and anti-inflammatory effects against CIN in rats.Öğe Added value of DCE-MRI in the management of cystic-cavitary lung lesions(Wiley, 2016) Karaman, Adem; Araz, Ömer; Durur Subaşı, Irmak; Alper, Fatih; Subaşı, Mahmut; Karakaya, Afak; Akgün, MetinBackground and objectiveWe evaluated the added value of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to CT in the evaluation of cystic-cavitary lung lesions. We aimed to compare morphological parameters, including wall thickness and inner wall irregularity, and to determine whether DCE-MRI with morphological and dynamic parameters was useful in indeterminate lesions. We also aimed to investigate the added value of DCE-MRI in terms of whether to biopsy, and if so the site of biopsy. MethodsThis prospective study included 39 consecutive patients with cystic and/or cavitary lung lesions detected by CT who then underwent additional DCE-MRI. After initial evaluation, the lesions were classified as benign, indeterminate or malignant and the findings of CT and DCE-MRI compared with each other by considering the final diagnosis that was determined by histopathological findings and clinical evaluation and follow up. ResultsThe mean values for wall thickness obtained by DCE-MRI were lower and the range of wall thickness for indeterminate lesions was narrower than those obtained by CT (5.50-11.50mm and 5.75-13.50mm for DCE-MRI and CT), and inner wall irregularity on DCE-MRI was more sensitive in malignant lesions. Also, DCE-MRI obviated biopsy in three benign patients and changed the biopsy site in two patients. ConclusionOur study suggests that DCE-MRI is helpful in indeterminate cystic-cavitary lung lesions, with morphological and dynamic features. It narrowed the range of wall thickness used for indeterminate lesions, was more sensitive than CT in determining malignant inner wall irregularity, and was also useful in determining the need for and appropriate site of biopsy. DCE-MRI is helpful in the assessment of the morphological and dynamic features of cystic-cavitary lung lesions. It is more sensitive than CT in the evaluation of wall thickness and irregularity. Lesion characteristics on DCE-MRI help identify the solid component and also determine the appropriate site for biopsy.Öğe Does the cardiovascular drug levosimendan prevent iodinated contrast medium nephrotoxicity with glycerol aggravation in rats?(Springer Nature, 2021) Durur Subaşı, Irmak; Köse, Duygu; Yayla, Muhammed; Şirin, Büşra; Karaman, Adem; Çalık, İlknur; Alper, FatihBackground We investigated whether levosimendan prevents contrast medium nephrotoxicity with glycerol aggravation in rats. Methods Forty-eight Wistar albino rats were assigned to eight groups (n = 6 x 8). No medication was administered to group I (controls); glycerol (intramuscular injection of 25% glycerol, 10 mL/kg) group II; intravenous iohexol 10 mL/kg to group III; glycerol and iohexol to group IV; iohexol and intraperitoneal levosimendan 0.25 mg/kg to group V; glycerol, iohexol, and levosimendan 0.25 mg/kg to group VI; iohexol and levosimendan 0.5 mg/kg to group VII; and glycerol, iohexol, and levosimendan 0.5 mg/kg to group VIII. One-day water withdrawal and glycerol injection prompted renal damage; iohexol encouraged nephrotoxicity; levosimendan was administered 30 min after glycerol injection and continued on days 2, 3, and 4. The experiment was completed on day 5. Serum blood urea nitrogen (BUN) and creatinine levels, superoxide dismutase (SOD) activity, glutathione (GSH), malondialdehyde (MDA) levels, tumour necrosis factor-alpha (TNF-alpha), nuclear factor kappa ss (NFK-ss), interleukin 6 (IL-6), and histopathological marks were assessed. One-way analysis of variance and Duncan's multiple comparison tests were used. Results Levosimendan changed serum BUN (p = 0.012) and creatinine (p = 0.018), SOD (p = 0.026), GSH (p = 0.012), and MDA (p = 0.011). Levosimendan significantly downregulated TNF-alpha (p = 0.022), NFK-ss (p = 0.008), and IL-6 (p = 0.033). Histopathological marks of hyaline and haemorrhagic cast were improved in levosimendan-injected groups. Conclusion Levosimendan showed nephroprotective properties due to its vasodilator, oxidative distress decreasing and inflammatory cytokine preventing belongings.Öğe Is it better to include necrosis in apparent diffusion coefficient (ADC) measurements? The necrosis/wall ADC ratio to differentiate malignant and benign lecrotic lung lesions: Preliminary results(Wiley, 2017) Karaman, Adem; Durur Subaşı, Irmak; Alper, Fatih; Durur Karakaya, Afak; Subaşı, Mahmut; Akgün, MetinPurpose: To determine whether the use of necrosis/wall apparent diffusion coefficient (ADC) ratios in the differentiation of necrotic lung lesions is more reliable than measuring the wall alone. Materials and Methods: In this retrospective study, a total of 76 patients (54 males and 22 females, 71% vs. 29%, with a mean age of 53 +/- 18 years, range, 18-84) were enrolled, 33 of whom had lung carcinoma and 43 had a benign necrotic lung lesion. A 3T scanner was used. The calculation of the necrosis/wall ADC ratio was based on ADC values measured from necrosis and the wall of the lesions by diffusion-weighted imaging (DWI). Statistical analyses were performed with the independent samples t-test and receiver operating characteristic analysis. Intraobserver and interobserver reliability were calculated for ADC values of wall and necrosis. Results: The mean necrosis/wall ADC ratio was 1.67 +/- 0.23 for malignant lesions and 0.75 +/- 0.19 for benign lung lesions (P < 0.001). To estimate malignancy the area under the curve (AUC) values for necrosis ADC, wall ADC, and the necrosis/wall ADC ratio were 0.720, 0.073, and 0.997, respectively. A wall/necrosis ADC ratio cutoff value of 1.12 demonstrated a 100% sensitivity and 98% specificity in the estimation of malignancy. Positive predictive value was 100%, and negative predictive value 98% and diagnostic accuracy 99%. There was a good intraobserver and interobserver reliability for wall and necrosis. Conclusion: The necrosis/wall ADC ratio appears to be a reliable and promising tool for discriminating lung carcinoma from benign necrotic lung lesions than measuring the wall alone.Öğe Is the necrosis/wall ADC ratio useful for the differentiation of benign and malignant breast lesions?(British Institute of Radiology, 2017) Durur Subaşı, Irmak; Durur Karakaya, Afak; Karaman, Adem; Şeker, Mehmet; Demirci, Elif; Alper, FatihObjective: To determine whether the necrosis/wall apparent diffusion coefficient (ADC) ratio is useful for the malignant-benign differentiation of necrotic breast lesions. Methods: Breast MRI was performed using a 3-T system. In this retrospective study, calculation of the necrosis/wall ADC ratio was based on ADC values measured from the necrosis and from the wall of malignant and benign breast lesions by diffusion-weighted imaging (DWI). By synchronizing post-contrast T1 weighted images, the separate parts of wall and necrosis were maintained. All the diagnoses were pathologically confirmed. Statistical analyses were conducted using an independent sample t-test and receiver operating characteristic analysis. The intraclass and interclass correlations were evaluated. Results: A total of 66 female patients were enrolled, 38 of whom had necrotic breast carcinomas and 28 of whom had breast abscesses. The ADC values were obtained from both the wall and necrosis. The mean necrosis/wall ADC ratio (6 standard deviation) was 1.6160.51 in carcinomas, and it was 0.6560.33 in abscesses. The area under the curve values for necrosis ADC, wall ADC and the necrosis/wall ADC ratio were 0.680, 0.068 and 0.942, respectively. A wall/necrosis ADC ratio cut-off value of 1.18 demonstrated a sensitivity of 97%, specificity of 93%, a positive-predictive value of 95%, a negative-predictive value of 96% and an accuracy of 95% in determining the malignant nature of necrotic breast lesions. There was a good intra- and interclass reliability for the ADC values of both necrosis and wall. Conclusion: The necrosis/wall ADC ratio appears to be a reliable and promising tool for discriminating breast carcinomas from abscesses using DWI. Advances in knowledge: ADC values of the necrosis obtained by DWI are valuable for malignant-benign differentiation in necrotic breast lesions. The necrosis/wall ADC ratio appears to be a reliable and promising tool in the breast imaging field.Öğe Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)(BMC, 2022) Yuan, Qian-Qian; Xiao, Shu-Xuan; Farouk, Omar; Du, Yu-Tang; Sheybani, Fereshte; Tan, Qing Ting; Akbulut, Sami; Çetin, Kenan; Alikhassi, Afsaneh; Yaghan, Rami Jalal; Durur Subaşı, Irmak; Altıntoprak, Fatih; Eom, Tae Ik; Alper, Fatih; Hasbahçeci, Mustafa; Martinez-Ramos, David; Öztekin, Pelin Seher; Kwong, Ava; Pluguez-Turull, Cedric W.; Brownson, Kirstyn E.; Chandanwale, Shirish; Habibi, Mehran; Lan, Liu-Yi; Zhou, Rui; Zeng, Xian-Tao; Bai, Jiao; Bai, Jun-Wen; Chen, Qiong-Rong; Chen, Xing; Zha, Xiao-Ming; Dai, Wen-Jie; Dai, Zhi-Jun; Feng, Qin-Yu; Gao, Qing-Jun; Gao, Run-Fang; Han, Bao-San; Hou, Jin-Xuan; Hou, Wei; Liao, Hai-Ying; Luo, Hong; Liu, Zheng-Ren; Lu, Jing-Hua; Luo, Bin; Ma, Xiao-Peng; Qian, Jun; Qin, Jian-Yong; Wei, Wei; Wei, Gang; Xu, Li-Ying; Xue, Hui-Chao; Yang, Hua-Wei; Yang, Wei-Ge; Zhang, Chao-Jie; Zhang, Fan; Zhang, Guan-Xin; Zhang, Shao-Kun; Zhang, Shu-Qun; Zhang, Ye-Qiang; Zhang, Yue-Peng; Zhang, Sheng-Chu; Zhao, Dai-Wei; Zheng, Xiang-Min; Zheng, Le-Wei; Xu, Gao-Ran; Zhou, Wen-Bo; Wu, Gao-SongGranulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence. Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions, etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology. The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidence-based consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.Öğe Management of granulomatous lobular mastitis: An international multidisciplinary consensus (2021 edition) (vol 9, 20, 2022)(BMC, 2022) Yuan, Qian-Qian; Xiao, Shu-Yuan; Farouk, Omar; Du, Yu-Tang; Sheybani, Fereshte; Tan, Qing Ting; Akbulut, Sami; Çetin, Kenan; Alikhassi, Afsaneh; Yaghan, Rami Jalal; Durur Subaşı, Irmak; Altıntoprak, Fatih; Eom, Tae Ik; Alper, Fatih; Hasbahçeci, Mustafa; Martinez-Ramos, David; Öztekin, Pelin Seher; Kwong, Ava; Pluguez-Turull, Cedric W.; Brownson, Kirstyn E.; Chandanwale, Shirish; Habibi, Mehran; Lan, Liu-Yi; Zhou, Rui; Zeng, Xian-Tao; Bai, Jiao; Bai, Jun-Wen; Chen, Qiong-Rong; Chen, Xing; Zha, Xiao-Ming; Dai, Wen-Jie; Dai, Zhi-Jun; Feng, Qin-Yu; Gao, Qing-Jun; Gao, Run-Fang; Han, Bao-San; Hou, Jin-Xuan; Hou, Wei; Liao, Hai-Ying; Luo, Hong; Liu, Zheng-Ren; Lu, Jing-Hua; Luo, Bin; Ma, Xiao-Peng; Qian, Jun; Qin, Jian-Yong; Wei, Wei; Wei, Gang; Xu, Li-Ying; Xue, Hui-Chao; Yang, Hua-Wei; Yang, Wei-Ge; Zhang, Chao-Jie; Zhang, Fan; Zhang, Guan-Xin; Zhang, Shao-Kun; Zhang, Shu-Qun; Zhang, Ye-Qiang; Zhang, Yue-Peng; Zhang, Sheng-Chu; Zhao, Dai-Wei; Zheng, Xiang-Min; Zheng, Le-Wei; Xu, Gao-Ran; Zhou, Wen-Bo; Wu, Gao-Song[Abstract Not Available]Öğe Multisystem imaging findings of a case with relapsing polichondritis(2016) Karakaya, Afak Durur; Karaman, Adem; Alper, FatihRelapsing polychondritis is a rare immune-mediated systemic inflammatory disease. It is associated with inflammation in cartilaginous tissue and primarily affects cartilaginous structures of the ears, nose and tracheobronchial tree but also the joints, the inner ear, the eyes, and the cardiovascular system (1). With this report we share the multisystem imaging findings of a case with relapsing polychondritis.Öğe The use of breast magnetic resonance imaging parameters to identify possible signaling pathways of a serum biomarker, HE4(Lippincott Williams & Wilkins, 2016) Durur Karakaya, Afak; Durur Subaşı, Irmak; Karaman, Adem; Akçay, Mufide Nuran; Palabıyık, Şaziye Sezin; Erdemci, Burak; Alper, Fatih; Acemoğlu, HamitObjectives: This study aimed to investigate the relationship between breast magnetic resonance imaging (MRI) parameters; clinical features such as age, tumor diameter, N, T, and TNM stages; and serum human epididymis protein 4 (HE4) levels in patients with breast carcinoma and use this as a means of estimating possible signaling pathways of the biomarker, HE4. Methods: Thirty-seven patients with breast cancer were evaluated by breast MRI and serum HE4 levels before therapy. Correlations between parameters including age, tumor diameter T and N, dynamic curve type, enhancement ratio (ER), slope wash in (S-WI), time to peak (TTP), slope washout (S-WO), and the serum level of HE4 were investigated statistically. Human epididymis protein 4 levels of early and advanced stage of disease were also compared statistically. Results: Breast MRI parameters showed correlation to serum HE4 levels and correlations were statistically significant. Of these MRI parameters, S-WI had higher correlation coefficient than the others. Human epididymis protein 4 levels were not statistically different in early and advanced stage of disease. Conclusions: High correlation with MRI parameters related to neo-angiogenesis may indicate signaling pathway of HE4.
