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  • Küçük Resim
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    Comparison of the histologic changes in conchae induced by radiofrequency thermal ablation and submucosal diathermy
    (Springer, 2013) Kaplama, Mehmet Erkan; Kaygusuz, İrfan; Akpolat, Nusret; Karlıdağ, Turgut; Keleş, Erol; Alpay, Hayrettin Cengiz; Yalçın, Şinasi; Orhan, İsrafil
    Objective of study was to determine the histological change induced in the conchae by submucosal diathermy and radiofrequency thermal ablation, two techniques used in the treatment of lower conchal hypertrophy, and to compare the two methods to each other. The study was performed on 15 rabbits. Radiofrequency was applied to the study animals in Group I (n = 5) and submucosal diathermy to Group II (n = 5), while Group III (n = 5) was the untreated control. The animals were decapitated 21 days after treatment and their conchae nasales ventrales excised on both sides. Histology slides were prepared and evaluated by light microscopy for ciliary loss, increase in submucosal vascularity, loss of goblet cells, inflammatory cellular infiltration, fibrosis and epithelial damage. The differences between Groups I and III were not significant regarding ciliary loss, increase in submucosal vascularity, loss of goblet cells and epithelial damage (p > 0.05), while the inflammatory cellular infiltration and fibrosis were significantly different between these groups (p < 0.05). As for the differences between Groups II and III, they were significant for each of the compared parameters (p < 0.05), while among Groups I and II they were significant for ciliary loss (p < 0.05), increase in submucosal vascularity, loss of goblet cells, inflammatory cellular infiltration and epithelial damage but not fibrosis (p > 0.05). Based on these findings, we can state that the use of radiofrequency thermal ablation causes less change in the normal conchal histology than submucosal diathermy application.
  • Küçük Resim
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    Internal acousticchannel diameter in sudden hearing loss sensorineural
    (Fırat Üniversitesi Tıp Fakültesi, 2013) Alpay, Hayrettin Cengiz; Yıldırım, Hanifi; Kaygusuz, İrfan; Karlıdağ, Turgut; Keleş, Erol; Orhan, İsrafil; Yalçın, Şinasi
    Objective: The purpose of our study was to determine the corelation between internal acoustic channel diameter and idiopathic sensorineural hearing loss. Material and Method: We defined sudden sensorineural hearing loss according to the criteria of Wilson as a 30-dB sensorineural hearing loss occurring in at least three contiguous frequencies in less than 3 days. The internal acoustic channel diameter all of the patients was measured from three dimensional temporal CT scan. Results: Of the 15 patients, 7 were male and 8 were female, ranging in age from 17 to 59 and the mean age was 39.6 years. The right ear was involved in 6 patients, and the left ear in 9. There was no statistically significant difference between the patients’ affected and intact ears (p>0.05). However, the mean diameter of affected side of the patients was narrower than those of healthy controls (p<0.05). Conclusion: When we compare our results with control group, we have shown that the diameter of the channel can be significantly related to sudden deafness. According to our data, a narrow channel can be a risk factor.
  • Küçük Resim
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    The effect of BMP-2, BMP-4 and BMP-6 on bone destruction of cholesteatoma presence
    (2013) Öger, Muzaffer; Alpay, Hayrettin Cengiz; Orhan, İsrafil; Önalan Ethem, Ebru; Yanılmaz, Muhammed; Sapmaz, Emrah
    The aim of our study was to investigate the relationship between the destruction of temporal bone structures, ossicular chain destruction, dissemination of cholesteatoma and the expressions of bone morphogenetic proteins (BMPs), BMP-2, BMP-4 and BMP-6 in patients with acquired cholesteatoma. Material and Methods: This study was performed in a total of 80 patients with cholesteatoma and without cholesteatoma who had undergone surgery due to chronic otitis media. The patients were grouped as the study and the control groups. The study group comprised patients with primary acquired cholesteatoma, and the control group consisted of chronic otitis media patients without cholesteatoma. The samples were obtained from cholesteatoma tissue and the external acoustic meatus skin in study group patients and they were obtained from the external acoustic meatus skin only in control group patients. The Reverse Transcriptase Polymerase Chain Reaction method was used for the measurements of BMPs, BMP-2, BMP-4 and BMP-6 expressions. Polymerase Chain Reaction was studied by isolation of Ribonucleic Acid from the tissue samples. Results: When the expressions of BMP in the external acoustic meatus skin were compared between the study and the control groups, the BMPs, BMP-2 and BMP-6 were determined to have a statistically significant relation in the study group (p < 0.05), but BMP-4 was not significant (p > 0.05). When the expression of BMP in cholesteatoma tissue was investigated in the study group patients, the BMPs, BMP-2 and BMP-6 were determined with statistically significant positivity (p < 0.05), but there was no significant positivity for BMP-4 (p > 0.05). In the study group, there was no statistical significance between the expressions of BMPs, BMP-2, BMP-4 and BMP-6 in cholesteatoma tissue, in the external acoustic meatus skin, and temporal and ossicular chain destruction, and dissemination of cholesteatoma (p > 0.05). A statistically significant positivity for BMPs expression in cholesteatoma tissue was determined in patients with destruction of the incus + malleus + stapes (p < 0.05). Conclusion: The expressions of BMPs, BMP-2 and BMP-6, were elevated in cholesteatoma tissue. Furthermore, the positivity of BMPs expression was statistically significant in patients with destruction of all the ossicles, and we think that this marker can be used for evaluation of the aggressiveness of cholesteatoma.