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    Relationship between serum DHEAS and oxidative stress levels of body mass index in healthy postmenopausal women
    (Taylor & Francis Ltd, 2016) Göy, Burhan; Atmaca, Murat; Aslan, Mehmet; Üçler, Rıfkı; Alay, Murat; Seven, İsmet; Demir, Halit; Öztürk, Mustafa
    Objectives: Menopause is a natural step in the process of aging. Postmenopausal women have decreased levels of antioxidants and increased oxidative stress, the latter of which plays an important role in atherogenesis. The aim of the present study was to evaluate the relationship of the body mass index (BMI) with serum catalase activity, malondialdehyde (MDA), and dehydroepiandrosterone sulfate (DHEAS) levels in healthy postmenopausal women and estimate whether the MDA/DHEAS ratio is a possible marker of oxidative stress for determining cardiovascular risk in these women. Methods: We investigated serum catalase activity, MDA, and DHEAS levels, parity history, age, and BMI in 96 healthy postmenopausal women aged 50-82 years. The serum MDA levels and catalase activity were measured spectrophotometrically. The serum DHEAS levels were measured using an enzyme-linked immunosorbent assay. The ratio percentage of the serum DHEAS levels to serum MDA levels was designated as a biomarker for oxidative stress. Results: The mean BMI of the patients was 31.72 +/- 6.16 kg/m(2) (range = 20.5-47.94). The MDA/DHEAS ratio was significantly decreased in patients with a BMI over 30 compared to that of patients with a BMI between 25 and 30 (P = 0.025). Moreover, BMI was positively correlated with serum DHEAS levels (r = 0.285, P < 0.01) and negatively correlated with the MDA/DHEAS ratio (r = -0.241, P < 0.05) in postmenopausal women. Furthermore, BMI was observed to be a potential predictor of the MDA/DHEAS ratio based on covariance analysis (P = 0.039). Conclusions: Our results indicate that healthy, obese, postmenopausal women have a decreased MDA/DHEAS ratio. Additionally, BMI was observed to be a potential predictor of the MDA/DHEAS ratio.
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    Severe hyoglycemic attacks and remission of type 2 diabetes and psoriasis due to acitretin
    (Modestum Ltd, 2016) Shukurov, Samir; Erkoç, Reha; İlhan, Mahmut Muzaffer; Özdemir, Mustafa; Alay, Murat; Taşan, Ertuğrul
    An 59 year old women with type two diabetes and psoriasis admitted with severe hypoglycemic attacks. Acitretin use was identified as the cause of this attacks. Two years after cessation of acitretin, she is still in remission of diabetes and psoriasis. This condition was attributed to extraordinary prolonged use of acitretin.
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    The effects of taxifolin on neuropathy related with hyperglycemia and neuropathic pain in rats: A biochemical and histopathological evaluation
    (Wroclaw University of Medicine, 2022) Alay, Murat; Sönmez, Miyase Gülçin; Sakin, Ayşegül; Atmaca, Murat; Süleyman, Halis; Yazıcı, Gülce Naz; Çoban, Abdulkadir; Süleyman, Bahadır; Bulut, Seval; Altuner, Durdu
    Background. Hyperglycemia can be considered a determining factor in the development of diabetic neuropathy as well as neuropathic pain. There is a relationship between the excessive production of reactive oxygen species (ROS) and the pathogenesis of diabetic neuropathic pain. Taxifolin, on the other hand, is a flavonoid that has been documented to inhibit ROS production. Objectives. To investigate the effects of taxifolin, which has antioxidant and neuroprotective effects, on alloxan-induced hyperglycemia-induced neuropathy and neuropathic pain, biochemically and histopathologically. Materials and methods. The albino Wistar male rats were divided into 3 groups: Healthy group (HG), only alloxan group (AXG) and alloxan+taxifolin group (ATG). Hyperglycemia in animals was caused through intraperitoneal injection of alloxan at a dose of 120 mg/kg. Paw pain thresholds of animals were measured using Basile algesimeter. Sciatic nerve tissues were examined biochemically and histopathologically in order to evaluate neuropathy. Results. Our experimental results revealed that taxifolin significantly prevented the increase of plasma glucose concentration level with alloxan administration, the decrease of the paw pain threshold related to hyperglycemia, the change of oxidant-antioxidant balance in the sciatic nerve tissue in favor of oxidants, and the deterioration of tissue morphology in animals. Conclusions. Our experimental results indicate that taxifolin alleviates alloxan-induced hyperglycemia-related neuropathy and neuropathic pain.