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Öğe Auditory pathway features determined by DTI in subjects with unilateral acoustic neuroma(Springer Heidelberg, 2016) Kurtcan, Serpil; Alkan, Alpay; Kılıçarslan, Rukiye; Bakan, Ayşe Ahsen; Toprak, Hüseyin; Aralaşmak, Ayşe; Aksoy, Fadlullah; Koçer, AbdülkadirIn the studies concerning the pathology of the auditory pathway in the vestibulocochlear system, few use advanced neuroimaging applications of magnetic resonance imaging (MRI) such as diffusion tensor imaging (DTI). Those who did use reported DTI changes only at the lateral lemniscus and inferior colliculus level. The aim of our study was to determine diffusion changes in the bilateral auditory pathways of subjects with unilateral acoustic neuroma (AN) and compare them with healthy controls. A total of 15 subjects with unilateral AN along with 11 controls underwent routine MRI and DTI. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values obtained from the lateral lemniscus, inferior colliculus, corpus geniculatum mediale, and Heschl's gyrus of the auditory pathway were then compared. The subjects' ADC values measured from the contralateral side were significantly higher at the lateral lemniscus, inferior colliculus, and corpus geniculatum mediale compared with those of the controls. Also, decreased FA values were noted at the inferior colliculus for both the contralateral and ipsilateral sides. The highest ADC values were detected in the inferior colliculus of the auditory pathway. In the auditory pathway of subjects with AN, the contralateral side is more affected than the ipsilateral side, the most affected region being the inferior colliculus. DTI is an advanced neuroimaging technique that can be used to determine the presence of microstructural damage to the auditory pathway in subjects with AN, whereas conventional MRI is not sensitive enough to detect damage.Öğe Effects of a thermosensitive in situ gel containing mometasone furoate on a rat allergic rhinitis model(Sage Publications Inc, 2018) Altuntaş, Ebru; Yener, Gülgün; Doğan, Remzi; Aksoy, Fadlullah; Aydın, Mehmet Şerif; Karataş, ErsinBackground: Mometasone furoate, one of the second generation intranasal corticosteroids, is currently used in suspension form due to its poor solubility. However, this is not favorable for nasal application because of the rapid elimination of the instilled drug from the nasal cavity by mucociliary clearance and delayed onset of action due to the slow dissolution of drug in suspension. Objective: The aim of this study was to determine the antiallergic effects of mucoadhesive thermosensitive in situ gel containing mometasone furoate that we developed previously to prolong the contact between the drug and nasal mucosa and to prevent drainage of the formulation in an ovalbumin-induced rat model of allergic rhinitis. Methods: An experimental allergic rhinitis model was developed in female Wistar albino rats by intraperitoneal injection of ovalbumin every 2 days for 14 days followed by its repeated intranasal instillation for 7 consecutive days. Intranasal instillation of ovalbumin was continued every other day for 14 days. Mometasone furoate in situ gel (5 mu g/10 mu l), mometasone furoate suspension (5 mu g/10 mu l), and physiological saline (10 ml) were administered into the bilateral nasal cavities from day 22 to day 35. Antiallergic effects were evaluated through histopathological evaluation, analysis of ovalbumin-specific serum immunoglobulin E, and a symptom score. Results: Mometasone furoate in situ gel significantly decreased the nasal symptoms and ovalbumin-specific serum immunoglobulin E level as compared with mometasone furoate suspension and physiological saline. Additionally, inflammatory histological symptoms such as mucosal edema, vascular dilatation, eosinophil infiltration, and loss of cilia within the nasal mucosa of allergic rhinitis model rats were remarkably improved with the treatment of mometasone furoate in situ gel. Conclusion: These results suggest that mometasone furoate in situ gel has a better therapeutic potential for the treatment of allergic rhinitis compared to mometasone furoate suspension.Öğe Histopathological evaluation of Ankaferd blood stopper use in the rabbit septoplasty model(Elsevier Ireland, 2015) Orhan, İsrafil; Do?an, Remzi; Soylu, Erkan; Aksoy, Fadlullah; Veyseller, Bayram; Özturan, Orhan; Eşrefo?lu, Mukaddes; Aydın, Mehmet ŞerifObjective: The purpose of this study was to assess the use of Ankaferd blood stopper (ABS), an organic hemostatic agent of plant origin, in septoplasty operations, and to determine its effect on nasal septal tissues in the rabbit model. Method: The study was performed on 30 New Zealand adult male rabbits each weighing 2500-3500 g (average: 3000 g). The rabbits were randomly divided into 4 groups, namely, the control group (without septoplasty), the septoplasty + tampon group, the septoplasty + ABS group, and the septoplasty + tampon + ABS group. All animals were sacrificed after two weeks, and the nasal septums were total removed using the lateral rhinotomy technique. The specimens were obtained from similar sites of cartilaginous nasal septum. The sections were stained with hematoxylin-eosin and Mason trichrome stains and studied under the light microscope by the same pathologist who evaluated the mucosal ulcerations, the severity of inflammatory cell infiltration, the mucosal thickness, and the cartilage thickness. The data obtained were statistically analyzed using the Kruskal-Wallis variance analysis and the Mann-Whitney U test. Results: No mucosal ulceration or inflammatory cell infiltration was detected in any of the rabbit groups. There was a statistically significant difference between the groups in terms of mucosal thickness and cartilage thickness (p < 0.05). The values of mucosal thickness in the groups mentioned above were 147.7 +/- 17.6 mu m, 205.7 +/- 36.7 mu m, 139.6 +/- 14.8 mu m, and 190.2 +/- 17.5 mu m, respectively. The values of cartilage thickness were 398.2 +/- 28.9 mu m, 546.2 +/- 35.3 mu m, 363.7 +/- 24.7 mu m, and 447.8 +/- 28.2 mu m, respectively. There was no significant difference between the control group and the septoplasty + ABS group in terms of mucosal thickness and cartilage thickness (p > 0.05). However, there was a significant increase in nasal mucosal and cartilage thickness in tampon-using groups when compared with the other groups (p < 0.05). Conclusion: Although nasal tampons provide the contact of mucoperichondrium with the cartilage, they are generally accepted as a discomfort for patients. Ankaferd blood stopper can be used instead of nasal tampons to increase patient comfort.Öğe Investigation of the role of major respiratory viruses in the aetiology of nasal polyps using polymerase chain reaction technique(Cambridge University Press, 2014) Aksoy, Fadlullah; Yenigün, Alper; Doğan, Remzi; Yılmaz, Fahrettin; Özturan, Orhan; Yenigün, Vildan BetülObjective: We aimed to identify the role of major respiratory viruses in the aetiology of human nasal polyps using polymerase chain reaction technique. Methods: Thirty patients with nasal polyps and a group of 20 healthy patients (control group) were included in this study. Mucosa was obtained from the polyps of patients with nasal polyposis and from the middle turbinate of the control group patients by means of biopsy. The samples were stored at -80 degrees C until molecular analysis by polymerase chain reaction was carried out. Results: In the control group, the human coronavirus and human rhinovirus were diagnosed in one of the patients and the human respiratory syncytial virus in another. In the group with nasal polyposis, the influenza B virus was identified in one of the patients and the human coronavirus in another. Conclusion: The results did not demonstrate a statistically significant relationship between nasal polyposis and respiratory viruses.Öğe Medical ozone therapy for the inner ear acoustic trauma(Elsevier Ireland Ltd, 2013) Yenigün, Alper; Aksoy, Fadlullah; Doğan, Remzi; Yılmaz, Fahrettin; Veyseller, Bayram; Özturan, Orhan; Öztürk, BurakObjectives: The goal of the study was to look at the potential protective effect of ozone therapy by studying its antioxidant and vasodilatation effects against hearing loss caused by acoustic trauma. Methods: Thirty-two male Wistar Albino rats were divided into four groups of eight. The 1st group was exposed to acoustic trauma, the 2nd group was treated with ozone initially, and was exposed to acoustic trauma 24 h later, the 3rd group received ozone without trauma, while the 4th group was the control group. The 1st and 2nd groups were exposed to acoustic trauma with 105 dB SPL white band noise for 4 h. DPOAE and ABR tests were conducted in all groups on the 1st, 5th, and 10th days after trauma. Results: In the 1st group, the effects of acoustic trauma continued on days 1, 5 and 10. The 2nd group's DPOAE and ABR results on days 5 and 10 showed significant improvement at all frequencies compared to deterioration on day 1, and the readings were comparable to baseline measurements. Conclusion: Acoustic trauma is a pathology that is experienced frequently and leads to many problems in terms of health and cost. Ozone was demonstrated to be a reparative substance against acoustic trauma and, in addition, it can be supplied and applied easily.
