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  • Küçük Resim
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    Anticonvulsant activity of resveratrol-loaded liposomes in vivo
    (Pergamon-Elsevier Science Ltd, 2017) Ethemoğlu, Muhsine Sinem; Şeker, Fatma Burcu; Akkaya, Hatice; Kılıç, Ertuğrul; Aslan, İsmail; Erdoğan, Cihan Süleyman; Yılmaz, Bayram
    Resveratrol (3,5,4'-stilbenetriol), a natural polyphenol produced by various plants, has attracted attention over the past decade because of its multiple beneficial properties, including anti-inflammatory, anti-oxidant and chemopreventive, yet, there is limited information about its antiepileptic effects. Moreover, its poor solubility in water and low bioavailability are the challenging issues. In the present study, we aimed to investigate effects of free resveratrol and resveratrol delivered in amphipathic liposomal delivery system, which has a high blood-brain barrier crossing potential, on penicillin-induced epileptic seizure model. For this purpose, adult male Sprague-Dawley rats were divided into four groups as saline (Control), liposome (LIP), free resveratrol (RES) and resveratrol + liposome (RES + LIP). Penicillin-induced epileptic activity was recorded for 120 min by electrocorticography. Glutathione S-transferase (GST), Glutathione (GSH), Superoxide dismutase (SOD) and Malondialdehyde (MDA) assays were performed in brain tissues collected. Our results showed that RES + LIP was the most effective anticonvulsant treatment on penicillin-induced epileptic seizures when compared to control, as RES + LIP immediately decreased the number of spikes per minute. GST and SOD activity, as well as the GSH levels, were significantly increased in the RES + LIP group as compared with the control group. Also, the MDA levels were significantly higher in the RES + LIP compared to RES and control groups. In conclusion, RES + LIP treatment was more effective on the decrease in spike frequency and spike amplitudes than other treatments. Our results suggest that the RES + LIP is more effective than RES on penicillin-induced epileptiform activity.
  • Küçük Resim Yok
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    Chronic manipulation of arcuate kisspeptin neurons in a(1-42) induced mouse model of alzheimer's disease
    (Karger, 2018) Aguş, Sami; Eyüboğlu, Siğnem; Solak, Hatice; Bilgin, Volkan Adem; Yavuz, Yavuz; Akkaya, Hatice; Özge, Başer; Kutlu, Selim; Aykut Bingöl, Canan; Atasoy, Deniz; Yılmaz, Bayram
    [Abstract Not Available]
  • Küçük Resim Yok
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    Effects of chronic modulation of kiss1 neurons on catecholamine levels in experimental alzheimer disease's model
    (Wiley, 2018) Aguş, Sami; Eyüboğlu, Siğnem; Solak, Hatice; Bilgin, Volkan Adem; Yavuz, Yavuz; Akkaya, Hatice; Başer, Özge; Kutlu, Selim; Bingöl, Canan Aykut; Atasoy, Deniz; Yılmaz, Bayram
    [Abstract Not Available]
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    Energy drink induced lipid peroxidation and oxidative damage in rat liver and brain when used alone or combined with alcohol
    (Wiley, 2017) Reis, Rengin; Charehsaz, Mohammad; Sipahi, Hande; Doğan Ekici, Asiye Işın; Macit, Çağlar; Akkaya, Hatice; Aydın, Ahmet
    Energy drinks (ED) are containing large doses of metabolic stimulants and its use with ethanol has increased dramatically among young adults. In this study, we examined the effects of ED exposure either alone or in combination with ethanol on oxidative stress parameters including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and lipid peroxidation parameter malondialdehyde (MDA) in rat. Some histopathological findings were also evaluated. ED exposure led to a dose-dependent increase in liver MDA compared to the control indicating oxidative damage. Histopathological findings also revealed that ED alone may generate liver damage. Ethanol exposure increased MDA level and SOD, CAT, and GSH-Px activity in both the brain and the liver. The combination of ethanol and ED produced greater damage which is considered by further increases in SOD and GSH-Px activity in the brain. Similar results for MDA were observed in both the liver and brain as well. Our findings suggest that ED consumption alone or combination with ethanol may represent a significant public health concern.
  • Küçük Resim
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    Postacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats
    (Wiley-Blackwell, 2014) Akkaya, Hatice; Kılıç, Ertuğrul; Eyüboğlu Dinç, Siğnem; Yılmaz, Bayram
    Apart from its effect on the regulation of reproductive function, recent studies indicate that kisspeptin may play roles in the antioxidant defense system. The antioxidant defense system and oxidative stress contribute to the etiology and pathogenesis of neuronal cell death after brain injury. We have investigated the postacute effect of kisspeptin-10 on brain injury induced by L-methionine. DNA fragmentation, malondialdehyde (MDA), reduced glutathione levels, and superoxide dismutase (SOD) activities were analyzed. Our results showed that methionine treatment increases apoptotic cell death. Kisspeptin alone showed no side effect on apoptotic cell death. However, kisspeptin treatment reversed the proapoptotic effect of methionine associated with reduced MDA and increased glutathione levels. Furthermore, SOD activity was completely depleted in methionine-treated animals. In conclusion, our results revealed that delayed kisspeptin-10 treatment reduces neuronal cell death by activation of SOD activity.