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    Amifostine enhances the antioxidant and hepatoprotective effects of UW and HTK preservation solutions
    (Baishideng Publishing Group Inc, 2014) Akbulut, Sami; Sevmiş, Şinasi; Karakayalı, Hamdi; Bayraktar, Nilüfer; Unlukaplan, Müge; Öksüz, Ergün; Dağdeviren, Atilla
    AIM: To investigate whether amifostine contributes to the antioxidant and cytoprotective effects of histidine-tryptophan-ketoglutarate (HTK) and University of Wisconsin (UW) preservation solutions. METHODS: Forty-eight Sprague Dawley male rats were equally divided into six groups: (1) ringer Lactate (RL) group; (2) RL + amifostine (RL + A) group; (3) HTK group; (4) HTK + A group; (5) UW group; and (6) UW + A group. Rats in the RL + A, HTK + A and UW + A groups were administered amifostine intraperitoneally at a dose of 200 mg/kg prior to laparotomy. The RL group was perfused with RL into the portal vein. The RL + A group were perfused with RL into the portal vein after amifostine administration. The HTK group received an HTK perfusion while the HTK + A group received an HTK perfusion after administration of amifostine. The UW group received a perfusion of UW, while the UW + A group received a UW perfusion after amifostine administration. Liver biopsy was performed to investigate histopathological, immunochemical [transferase mediated dUTP nick end labeling (TUNEL), inducible nitric oxide syntetase (iNOS)] and ultrastructural alterations. Biochemical alterations were determined by examining levels of alanine aminotransferase, alkaline phosphatase and nitric oxide in the perfusion fluid. RESULTS: Pathological sinusoidal dilatation and centrilobular hydropic alteration were significantly lower in the groups that received amifostine prior to preservation solution perfusion. Although the best results were obtained in the UW + A group, we did not observe a statistically significant difference between the UW + A and HTK + A groups. iNOS grades were significantly lower in the amifostine groups 12 h after treatment. When the amifostine groups were compared against each other, the iNOS grades obtained from the UW + A and HTK + A groups were similar while the RL + A group had a much poorer score. TUNEL assays demonstrated a lower apoptosis ratio in the amifostine groups than in the non-amifostine groups 12 h after treatment. No statistically significant difference was observed between the UW + A and HTK + A groups for apoptosis. Cellular ultrastructure was best preserved in the UW + A and HTK + A groups. CONCLUSION: Here, we show that preoperative administration of a single dose of amifostine is sufficient to minimize the preservation damage in hepatic cells.
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    Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
    (BMC, 2022) Yuan, Qian-Qian; Xiao, Shu-Xuan; Farouk, Omar; Du, Yu-Tang; Sheybani, Fereshte; Tan, Qing Ting; Akbulut, Sami; Çetin, Kenan; Alikhassi, Afsaneh; Yaghan, Rami Jalal; Durur Subaşı, Irmak; Altıntoprak, Fatih; Eom, Tae Ik; Alper, Fatih; Hasbahçeci, Mustafa; Martinez-Ramos, David; Öztekin, Pelin Seher; Kwong, Ava; Pluguez-Turull, Cedric W.; Brownson, Kirstyn E.; Chandanwale, Shirish; Habibi, Mehran; Lan, Liu-Yi; Zhou, Rui; Zeng, Xian-Tao; Bai, Jiao; Bai, Jun-Wen; Chen, Qiong-Rong; Chen, Xing; Zha, Xiao-Ming; Dai, Wen-Jie; Dai, Zhi-Jun; Feng, Qin-Yu; Gao, Qing-Jun; Gao, Run-Fang; Han, Bao-San; Hou, Jin-Xuan; Hou, Wei; Liao, Hai-Ying; Luo, Hong; Liu, Zheng-Ren; Lu, Jing-Hua; Luo, Bin; Ma, Xiao-Peng; Qian, Jun; Qin, Jian-Yong; Wei, Wei; Wei, Gang; Xu, Li-Ying; Xue, Hui-Chao; Yang, Hua-Wei; Yang, Wei-Ge; Zhang, Chao-Jie; Zhang, Fan; Zhang, Guan-Xin; Zhang, Shao-Kun; Zhang, Shu-Qun; Zhang, Ye-Qiang; Zhang, Yue-Peng; Zhang, Sheng-Chu; Zhao, Dai-Wei; Zheng, Xiang-Min; Zheng, Le-Wei; Xu, Gao-Ran; Zhou, Wen-Bo; Wu, Gao-Song
    Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence. Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions, etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology. The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidence-based consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.
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    Management of granulomatous lobular mastitis: An international multidisciplinary consensus (2021 edition) (vol 9, 20, 2022)
    (BMC, 2022) Yuan, Qian-Qian; Xiao, Shu-Yuan; Farouk, Omar; Du, Yu-Tang; Sheybani, Fereshte; Tan, Qing Ting; Akbulut, Sami; Çetin, Kenan; Alikhassi, Afsaneh; Yaghan, Rami Jalal; Durur Subaşı, Irmak; Altıntoprak, Fatih; Eom, Tae Ik; Alper, Fatih; Hasbahçeci, Mustafa; Martinez-Ramos, David; Öztekin, Pelin Seher; Kwong, Ava; Pluguez-Turull, Cedric W.; Brownson, Kirstyn E.; Chandanwale, Shirish; Habibi, Mehran; Lan, Liu-Yi; Zhou, Rui; Zeng, Xian-Tao; Bai, Jiao; Bai, Jun-Wen; Chen, Qiong-Rong; Chen, Xing; Zha, Xiao-Ming; Dai, Wen-Jie; Dai, Zhi-Jun; Feng, Qin-Yu; Gao, Qing-Jun; Gao, Run-Fang; Han, Bao-San; Hou, Jin-Xuan; Hou, Wei; Liao, Hai-Ying; Luo, Hong; Liu, Zheng-Ren; Lu, Jing-Hua; Luo, Bin; Ma, Xiao-Peng; Qian, Jun; Qin, Jian-Yong; Wei, Wei; Wei, Gang; Xu, Li-Ying; Xue, Hui-Chao; Yang, Hua-Wei; Yang, Wei-Ge; Zhang, Chao-Jie; Zhang, Fan; Zhang, Guan-Xin; Zhang, Shao-Kun; Zhang, Shu-Qun; Zhang, Ye-Qiang; Zhang, Yue-Peng; Zhang, Sheng-Chu; Zhao, Dai-Wei; Zheng, Xiang-Min; Zheng, Le-Wei; Xu, Gao-Ran; Zhou, Wen-Bo; Wu, Gao-Song
    [Abstract Not Available]
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    Role of endoscopic retrograde cholangiopancreatography in the management of hepatic hydatid disease
    (Baishideng Publishing Group Inc, 2014) Dolay, Kemal; Akbulut, Sami
    Most cases of hepatic hydatid disease exhibit uncomplicated clinical course and management. However, the diagnosis and management of complicated hepatic hydatid disease is a special issue. One of the most common and serious complications of hepatic hydatid disease is the rupture of the cyst into intrahepatic bile ducts. The clinical appearance of intrabiliary rupture can range from asymptomatic to jaundice, cholecystitis, cholangitis, liver abscess, pancreatitis and septicemia. Current treatments for major ruptures can result in high morbidity and mortality rates. Furthermore, ruptures that cannot be diagnosed preoperatively can induce complications such as biliary fistulae, biloma, cavitary infection and obstructive jaundice. In the past, these complications were diagnosed and treated by surgical methods. Currently, complications in both the pre- and postoperative periods are diagnosed and treated by non-invasive or minimally invasive methods. In clinical practice, endoscopic retrograde cholangiopancreatography (ERCP) is indicated for patients with preoperative frank intrabiliary rupture in which hydatid elements are clearly seen in the bile ducts, or for biliary adverse events after surgery, including persistent biliary fistulae and jaundice. However, controversy concerning routine preoperative ERCP and prophylactic endoscopic sphincterotomy in patients suspected of having minor cystobiliary communications still remains. In this article, the role of ERCP in the diagnosis and management of hepatic hydatid disease during the pre- and postoperative periods is reviewed.