dc.contributor.author | Dişel, Umut | |
dc.contributor.author | Köse, Fatih | |
dc.contributor.author | Bilici, Ahmet | |
dc.contributor.author | Özgüroğlu, Mustafa | |
dc.contributor.author | Sağlam, Sezer | |
dc.contributor.author | Şeker, Mesut | |
dc.contributor.author | Aksoy, Sercan | |
dc.contributor.author | Tek, İbrahim | |
dc.contributor.author | Mandel, Nil Molinas | |
dc.contributor.author | Demir, Gökhan | |
dc.contributor.author | Arslan, Çağatay | |
dc.contributor.author | Demiray, Mutlu | |
dc.contributor.author | Öztürk, Mehmet Akif | |
dc.contributor.author | Salepçi, Taflan | |
dc.contributor.author | Eralp, Yeşim | |
dc.contributor.author | Selçukbiricik, Fatih | |
dc.contributor.author | Temizaş, Gökçe | |
dc.contributor.author | Fidan, Ebru Gül | |
dc.date.accessioned | 2022-09-15T12:16:01Z | |
dc.date.available | 2022-09-15T12:16:01Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Dişel, U., Köse, F., Bilici, A., Özgüroğlu, M., Sağlam, S., Şeker, M. ... Fidan, E. G. (2022). The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors. Journal of Oncological Science, 8(2), 87-93. https://doi.org/10.37047/jos.2022-89310 | en_US |
dc.identifier.issn | 2651-4532 | |
dc.identifier.issn | 2452-3364 | |
dc.identifier.uri | https://doi.org/10.37047/jos.2022-89310 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9715 | |
dc.description.abstract | Objective: The development of bioinformatics and comprehensive genomic profiling (CGP) has provided insights into the ap-plicability and functionality of the genomic alterations (GA). In this study, we evaluated the impact of CGP on the treatment plan and outcomes in a significant number of patients. Material and Methods: We carried out a retrospective case-control study on 164 adult patients with advanced solid tumors from 15 oncology centers in Türkiye. Results: In all cases, CGP was performed within 23.8 [standard deviation (SD)±32.1] months of initial diagnosis. Non-small cell lung carcinoma, breast cancer, unknown primary carcinoma, colorectal carcinoma, and sarcoma were among the most common tumor types, accounting for 61.5% of all cases. CGP was performed immediately after the diagnosis of advanced cancer in 13 patients (7.9%). In 158 patients (96.4%), at least one GA was found as per the CGP report. Also, in the reports, the average tumor mutational burden (TMB) and GAs were 7.3 (SD±8.7) mut/Mb and 3.5 (SD±2.0), respectively. According to CGP reports, 58 patients had 79 evidence-based drug suggestions for their particular tumor type, whereas 97 patients had 153 evidence-based drug suggestions for another tumor type. After the primary oncologist interpreted the CGP reports, significant changes were made to the treatment of 35 (21.3%) patients. Conclusion: We strongly believe that in the future, high-TMB or other tumor-agnostic biomarkers will become much more afford-able, and CGP will serve as one of the major decision-making tools for the treatment of patients along with pathological, radiological or lab-oratory tests. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Turkiye Klinikleri | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Comprehensive Genomic Hybridization | en_US |
dc.subject | Genomics | en_US |
dc.subject | Neoplasms | en_US |
dc.subject | Retrospective Studies | en_US |
dc.title | The impact of hybrid capture-based comprehensive genomic profiling on treatment strategies in patients with solid tumors | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Oncological Science | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0443-6966 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 87 | en_US |
dc.identifier.endpage | 93 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.37047/jos.2022-89310 | en_US |
dc.institutionauthor | Bilici, Ahmet | |
dc.identifier.scopus | 2-s2.0-85136777670 | en_US |
dc.identifier.scopusquality | Q4 | en_US |