dc.contributor.author | Kazcı, Yusuf Enes | |
dc.contributor.author | Şahoğlu Göktaş, Sevilay | |
dc.contributor.author | Aydın, Mehmet Şerif | |
dc.contributor.author | Karadoğan, Behnaz | |
dc.contributor.author | Nebol, Aylin | |
dc.contributor.author | Turhan, Mehmet Uğurcan | |
dc.contributor.author | Öztürk, Gürkan | |
dc.contributor.author | Çağavi, Esra | |
dc.date.accessioned | 2022-08-08T06:30:18Z | |
dc.date.available | 2022-08-08T06:30:18Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Kazcı, Y. E., Şahoğlu Göktaş, S., Aydın, M. Ş., Karadoğan, B., Nebol, A., Turhan, M. U. ... Çağavi, E. (2022). Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach. Autonomic Neuroscience: Basic and Clinical, 242. https://doi.org/10.1016/j.autneu.2022.103019 | en_US |
dc.identifier.issn | 1566-0702 | |
dc.identifier.uri | https://doi.org/10.1016/j.autneu.2022.103019 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9635 | |
dc.description.abstract | Heart is an extensively innervated organ and its function is strictly coordinated by autonomic neural circuits. After pathological events such as myocardial infarction (MI), cardiac nerves undergo a structural and functional remodeling contributing to cardiac dysfunction. Although the efferent component of the cardiac nerves has been well described, sensory innervation of the heart has not been defined in detail. Considering its importance, comprehensive description of vagal afferent innervation on the whole heart would enable a better description of autonomic imbalances manifesting as sympathoexcitation and vagal withdrawal in post-ischemic states. To address this issue, we globally mapped the vagal nodose afferent fibers innervating the whole murine heart with unprecedented resolution. By using the Phox2b-Cre::tdTomato transgenic mouse line, we described the detailed distribution and distinct vagal sensory ending morphologies at both the dorsal and ventral sides of the mouse heart. By neural tracing analysis, we quantitated the distribution and prevalence of vagal afferent nerve fibers with varying diameters across dorsal and ventral surfaces of the heart. Moreover, we demonstrated that vagal afferents formed flower spray and end-net-like endings within the atria and ventricles. As distinct from the atria, vagal afferents formed intramuscular array-like endings within the ventricles. Furthermore, we showed that vagal afferents undergo structural remodeling by forming axonal sprouts around the infarct area in post-MI hearts. These findings improve our understanding of the potential effect of vagal afferent remodeling on autonomic imbalance and generation of cardiac arrhythmias and could prospectively contribute to the development of more effective neuromodulatory therapies. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Heart | en_US |
dc.subject | Myocardial Infarct | en_US |
dc.subject | Neural Remodeling | en_US |
dc.subject | Nodose Ganglia | en_US |
dc.subject | Vagal Afferents | en_US |
dc.subject | Whole Organ Imaging | en_US |
dc.title | Anatomical characterization of vagal nodose afferent innervation and ending morphologies at the murine heart using a transgenic approach | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Autonomic Neuroscience: Basic and Clinical | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü | en_US |
dc.department | İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Sinirbilim Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Tıbbi Biyoloji ve Genetik Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-6393-1465 | en_US |
dc.authorid | 0000-0003-0352-1947 | en_US |
dc.authorid | 0000-0002-7199-583X | en_US |
dc.identifier.volume | 242 | en_US |
dc.relation.tubitak | info:eu-repo/grantAgreement/TUBITAK/SOBAG/219S332 | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.autneu.2022.103019 | en_US |
dc.institutionauthor | Kazcı, Yusuf Enes | |
dc.institutionauthor | Şahoğlu Göktaş, Sevilay | |
dc.institutionauthor | Aydın, Mehmet Şerif | |
dc.institutionauthor | Karadoğan, Behnaz | |
dc.institutionauthor | Nebol, Aylin | |
dc.institutionauthor | Öztürk, Gürkan | |
dc.institutionauthor | Çağavi, Esra | |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.wos | 000883012500003 | en_US |
dc.identifier.scopus | 2-s2.0-85134827591 | en_US |
dc.identifier.pmid | 35905544 | en_US |
dc.identifier.scopusquality | Q2 | en_US |