dc.contributor.author | Sakin, Abdullah | |
dc.contributor.author | Özçelik, Mahsun | |
dc.contributor.author | Şahin, Süleyman | |
dc.contributor.author | Aydemir, Ozan | |
dc.contributor.author | Aldemir, Mehmet Naci | |
dc.contributor.author | İliklerden, Ümit Haluk | |
dc.contributor.author | Kotan, Mehmet Çetin | |
dc.date.accessioned | 2022-08-05T06:21:05Z | |
dc.date.available | 2022-08-05T06:21:05Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Sakin, A., Özçelik, M., Şahin, S., Aydemir, O., Aldemir, M. N., İliklerden, Ü. H. ... Kotan, M. Ç. (2022). The prognostic effect of pretreatment 18F-FDG PET/CT metabolic parameters in locally advanced esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Surgical Oncology-Oxford, 43. https://doi.org/10.1016/j.suronc.2022.101809 | en_US |
dc.identifier.issn | 0960-7404 | |
dc.identifier.issn | 1879-3320 | |
dc.identifier.uri | https://doi.org/10.1016/j.suronc.2022.101809 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9626 | |
dc.description.abstract | Introduction: In this study, we aimed to examine the relation between pre-treatment 18F-FDG PET/CT metabolic parameters [(including the maximum standard uptake value (SUVmax), metabolic tumor volume (MTV), and tumor lesion glycolysis (TLG)] and treatment response and survival in locally-advanced Esophageal Squamous Cell Cancer (ESCC) treated with definitive chemoradiotherapy (dCRT). Methods: A total 76 patients with locally-advanced ESCC who received dCRT between June 2015 and December 2019 were included in this retrospective study. Patients were divided into two groups as complete response (CR) or non-complete response (Non-CR) according to response to treatment. AUC was obtained as 0.749 (p < 0.001) in the ROC curve drawn by MTV for the CR. The MTV value was <= 12 cm(3), with 72.1% sensitivity and 73.0% specificity. Results: Of the 76 patients, 38 (50%) were male and 38 (50%) were female. The median age was 62 (39-84) years. The treatment response in 35 (46%) patients was CR. MTV value was > 12cm3 in 41(54%) patients. Median follow-up time was 14.5 months. In patients with MTV > 12cm3, median progression-free survival(mPFS) and median overall survival(mOS) were 9 months and 11 months, respectively, whereas mPFS and OS could not be reached in those with MTV & LE;12 cm3 (p < 0.001 and p < 0.001, respectively). In patients with non-CR, mPFS and mOS were 8 months and 9 months, respectively, whereas mPFS and OS could not be reached in patients with CR (p < 0.001 and p < 0.001, respectively). In multivariate analysis, age (odds ratio [OR], 1.07), ECOG PS (OR, 11.1), and MTV (OR, 4.73) were found to be the factors affecting treatment response. Conclusion: In our study, treatment response and MTV were found to be the factors associated with survival in patients treated with dCRT, showing the pre-treatment MTV value as a predictor of treatment response. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Ltd | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Metabolic Tumor Volume | en_US |
dc.subject | Tumor Lesion Glycolysis | en_US |
dc.subject | Esophageal Cancer | en_US |
dc.subject | Chemoradiotherapy | en_US |
dc.subject | Squamous Cell Carcinoma | en_US |
dc.title | The prognostic effect of pretreatment 18F-FDG PET/CT metabolic parameters in locally advanced esophageal squamous cell carcinoma treated with definitive chemoradiotherapy | en_US |
dc.title.alternative | The prognostic effect of pretreatment 18F-FDG PET/CT metabolic parameters in locally advanced Esophageal Squamous Cell Carcinoma treated with definitive chemoradiotherapy: 18F-FDG PET/CT Metabolic Parameters in Esophageal Cancer | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Surgical Oncology-Oxford | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-2538-8569 | en_US |
dc.identifier.volume | 43 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.suronc.2022.101809 | en_US |
dc.institutionauthor | Sakin, Abdullah | |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.wos | 000828401900003 | en_US |
dc.identifier.scopus | 2-s2.0-85134893767 | en_US |
dc.identifier.pmid | 35809492 | en_US |
dc.identifier.scopusquality | Q2 | en_US |