Basit öğe kaydını göster

dc.contributor.authorErdoğan, Fırat
dc.contributor.authorŞenkal, Evrim
dc.contributor.authorÖzer, Ömer Faruk
dc.contributor.authorİpek, İlke Özahi
dc.contributor.authorAltuntaş, Şükriye Leyla
dc.contributor.authorÖzde, Şükriye
dc.date.accessioned2022-06-17T07:52:12Z
dc.date.available2022-06-17T07:52:12Z
dc.date.issued2022en_US
dc.identifier.citationErdoğan, F., Şenkal, E., Özer, Ö. F., İpek, İ. Ö., Altuntaş, Ş. L. ve Özde, Ş. (2022). Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: A prospective study. Sao Paulo Medical Journal, 140(3), 390-397. http://doi.org/10.1590/1516-3180.2021.0209.R1.25082021en_US
dc.identifier.issn1516-3180
dc.identifier.urihttp://doi.org/10.1590/1516-3180.2021.0209.R1.25082021
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9530
dc.description.abstractBACKGROUND: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. OBJECTIVE: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). DESIGN AND SETTING: Prospective study at a university hospital in Turkey. METHODS: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as con-trols. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. RESULTS: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r =-0.386; P < 0.001) and between TOS and disulfide (r =-0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. CONCLUSION: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation.en_US
dc.language.isoengen_US
dc.publisherAssociacao Paulista Medicinaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectAntioxidantsen_US
dc.subjectDiabetes mellitusen_US
dc.subjectGestationalen_US
dc.subjectGestational Diabetes Mellitusen_US
dc.subjectOxidative Stress Indexen_US
dc.subjectStressen_US
dc.subjectOxidativeen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectTotal Oxidant Statusen_US
dc.titleOxidative stress in maternal milk and cord blood in gestational diabetes mellitus: A prospective studyen_US
dc.typearticleen_US
dc.relation.ispartofSao Paulo Medical Journalen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.authorid0000-0002-3075-2348en_US
dc.authorid0000-0002-9120-7642en_US
dc.authorid0000-0003-1985-552Xen_US
dc.identifier.volume140en_US
dc.identifier.issue3en_US
dc.identifier.startpage390en_US
dc.identifier.endpage397en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1590/1516-3180.2021.0209.R1.25082021en_US
dc.institutionauthorŞenkal, Evrim
dc.institutionauthorİpek, İlke Özahi
dc.institutionauthorAltuntaş, Şükriye Leyla
dc.identifier.wosqualityQ4en_US
dc.identifier.wos000806210800011en_US
dc.identifier.scopus2-s2.0-85131699864en_US
dc.identifier.pmid35508001en_US
dc.identifier.scopusqualityQ3en_US


Bu öğenin dosyaları:

Thumbnail

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster

info:eu-repo/semantics/openAccess
Aksi belirtilmediği sürece bu öğenin lisansı: info:eu-repo/semantics/openAccess