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dc.contributor.authorYener, Görsev
dc.contributor.authorHünerli Gündüz, Duygu
dc.contributor.authorYıldırım, Ebru
dc.contributor.authorAktürk, Tuba
dc.contributor.authorBaşar Eroğlu, Canan
dc.contributor.authorBonanni, Laura
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorFarina, Francesca
dc.contributor.authorFerri, Raffaele
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHajós, Mihály
dc.contributor.authorIbáñez, Agustín
dc.contributor.authorJiang, Yang
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopez, Susanna
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorParra, Mario A.
dc.contributor.authorRandall, Fiona
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorBabiloni, Claudio
dc.date.accessioned2022-06-17T06:47:22Z
dc.date.available2022-06-17T06:47:22Z
dc.date.issued2022en_US
dc.identifier.citationYener, G., Hünerli Gündüz, D., Yıldırım, E., Aktürk, T., Başar Eroğlu, C., Bonanni, L. ... Babiloni, C. (2022). Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease. International Journal of Psychophysiology, 177, 179-201. http://doi.org/10.1016/j.ijpsycho.2022.05.008en_US
dc.identifier.issn0167-8760
dc.identifier.issn1872-7697
dc.identifier.urihttp://doi.org/10.1016/j.ijpsycho.2022.05.008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9528
dc.description.abstractAlzheimer's disease dementia (ADD) is the most diffuse neurodegenerative disorder belonging to mild cognitive impairment (MCI) and dementia in old persons. This disease is provoked by an abnormal accumulation of amyloid-beta and tauopathy proteins in the brain. Very recently, the first disease-modifying drug has been licensed with reserve (i.e., Aducanumab). Therefore, there is a need to identify and use biomarkers probing the neurophysiological underpinnings of human cognitive functions to test the clinical efficacy of that drug. In this regard, event-related electroencephalographic potentials (ERPs) and oscillations (EROs) are promising candidates. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer's Association and Global Brain Consortium reviewed the field literature on the effects of the most used symptomatic drug against ADD (i.e., Acetylcholinesterase inhibitors) on ERPs and EROs in ADD patients with MCI and dementia at the group level. The most convincing results were found in ADD patients. In those patients, Acetylcholinesterase inhibitors partially normalized ERP P300 peak latency and amplitude in oddball paradigms using visual stimuli. In these same paradigms, those drugs partially normalize ERO phase-locking at the theta band (4–7 Hz) and spectral coherence between electrode pairs at the gamma (around 40 Hz) band. These results are of great interest and may motivate multicentric, double-blind, randomized, and placebo-controlled clinical trials in MCI and ADD patients for final cross-validation.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USAen_US
dc.language.isoengen_US
dc.publisherElsevier B.V.en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAlzheimeren_US
dc.subjectBiomarkeren_US
dc.subjectDementiaen_US
dc.subjectEEGen_US
dc.subjectEROsen_US
dc.subjectERPsen_US
dc.subjectEvent-relateden_US
dc.subjectMild Cognitive Impairmenten_US
dc.subjectMonitoringen_US
dc.subjectOscillationsen_US
dc.subjectP300en_US
dc.subjectTreatmenten_US
dc.titleTreatment effects on event-related EEG potentials and oscillations in Alzheimer's diseaseen_US
dc.typearticleen_US
dc.relation.ispartofInternational Journal of Psychophysiologyen_US
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Sinirbilim Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.authorid0000-0002-7715-3035en_US
dc.authorid0000-0002-7555-3801en_US
dc.authorid0000-0002-0860-0524en_US
dc.identifier.volume177en_US
dc.identifier.startpage179en_US
dc.identifier.endpage201en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.ijpsycho.2022.05.008en_US
dc.institutionauthorYıldırım, Ebru
dc.institutionauthorAktürk, Tuba
dc.institutionauthorGüntekin, Bahar
dc.identifier.wosqualityQ2en_US
dc.identifier.wos000808370700005en_US
dc.identifier.scopus2-s2.0-85131441990en_US
dc.identifier.pmid35588964en_US
dc.identifier.scopusqualityQ2en_US


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