dc.contributor.author | Yılmaz, Ünsal | |
dc.contributor.author | Anlar, Banu | |
dc.contributor.author | Gücüyener, Kıvılcım | |
dc.contributor.author | Yaramış, Ahmet | |
dc.contributor.author | Cansu, Ali | |
dc.contributor.author | Ünalp, Ayçan | |
dc.contributor.author | Aksoy, Ayşe | |
dc.contributor.author | Kaçar Bayram, Ayşe | |
dc.contributor.author | Kartal, Ayşe | |
dc.contributor.author | Tosun, Ayşe Fahriye | |
dc.contributor.author | Serdaroğlu, Ayşe | |
dc.contributor.author | Konuşkan, Bahadır | |
dc.contributor.author | Sarıoğlu, Berrak | |
dc.contributor.author | Yüzbaşı Kıpçak, Beste | |
dc.contributor.author | Kılıç Aydın, Betül | |
dc.contributor.author | Taşkın Dilge, Birce | |
dc.contributor.author | Bulut, Cahide | |
dc.contributor.author | Yılmaz, Cahide | |
dc.contributor.author | Yarar, Coşkun | |
dc.contributor.author | Okuyaz, Çetin | |
dc.contributor.author | Gençsel, Çiğdem | |
dc.contributor.author | Yüksel, Deniz | |
dc.contributor.author | Arslan Bengi, Elif | |
dc.contributor.author | Gürkaş, Esra | |
dc.contributor.author | Faruk, İncecik | |
dc.contributor.author | Serdaroğlu, Gül | |
dc.contributor.author | Deda, Gülhis | |
dc.contributor.author | Gürbüz, Gürkan | |
dc.contributor.author | Gümüş, Hakan | |
dc.contributor.author | Acer, Hamit | |
dc.contributor.author | Tekgül, Hasan | |
dc.contributor.author | Çaksen, Hüseyin | |
dc.contributor.author | Per, Hüseyin | |
dc.contributor.author | Erol, İlknur | |
dc.contributor.author | Çarman Kürşat, Bora | |
dc.contributor.author | Canpolat, Mehmet | |
dc.contributor.author | Özkan, Mehpare | |
dc.contributor.author | Direk Çobanoğulları, Meltem | |
dc.contributor.author | Kutluk Gültekin, Muhammed | |
dc.contributor.author | Arslan, Mutluay | |
dc.contributor.author | Sönmez, Fatma Müjgan | |
dc.contributor.author | Dündar, Olgaç Nihal | |
dc.contributor.author | Koçak, Ozan | |
dc.contributor.author | Aydın, Ömer Faruk | |
dc.contributor.author | Toptaş, Özge | |
dc.contributor.author | Duman, Özgür | |
dc.contributor.author | Hergüner, Mihriban Özlem | |
dc.contributor.author | Bozkurt, Öznur | |
dc.contributor.author | Arıcan, Pınar | |
dc.contributor.author | Yılmaz Keskin, Sanem | |
dc.contributor.author | Gökben, Sarenur | |
dc.contributor.author | Işıkay, Şedat | |
dc.contributor.author | Kumandaş, Sefer | |
dc.contributor.author | Edizer, Selvinaz | |
dc.contributor.author | Kurul Hız, Semra | |
dc.contributor.author | Saygı, Semra | |
dc.contributor.author | Teber Tiraş, Serap | |
dc.contributor.author | Güngör, Serdal | |
dc.contributor.author | Altunbaşak, Şakir | |
dc.contributor.author | Haspolat, Şenay | |
dc.contributor.author | Sezer, Taner | |
dc.contributor.author | Yılmaz Sevim, Tuba | |
dc.contributor.author | Yiş, Ulaç | |
dc.contributor.author | Öztoprak, Ülkühan | |
dc.contributor.author | Aydoğmuş, Ümmü | |
dc.contributor.author | Topçu, Yasemin | |
dc.contributor.author | Öztürk, Zeynep | |
dc.contributor.author | Karalök, Zeynep Selen | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:35:48Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:35:48Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Yılmaz, Ü., Anlar, B., Gücüyener, K., Yaramış, A., Cansu, A., Ünalp, A. ... Karalök, Z. S. (2017). Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database. European Journal of Paediatric Neurology, 21(6), 872-864. https://dx.doi.org/10.1016/j.ejpn.2017.06.004 | en_US |
dc.identifier.issn | 1090-3798 | |
dc.identifier.issn | 1532-2130 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/948 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.ejpn.2017.06.004 | |
dc.description.abstract | Objective To document the clinical and paraclinical features of pediatric multiple sclerosis (MS) in Turkey. Methods Data of MS patients with onset before age 18 years (n = 193) were collected from 27 pediatric neurology centers throughout Turkey. Earlier-onset (<12 years) and later-onset (?12 years) groups were compared. Results There were 123 (63.7%) girls and 70 (36.3%) boys aged 4–17 years, median 14 years at disease onset. Family history of MS was 6.5%. The first presentation was polysymptomatic in 55.4% of patients, with brainstem syndromes (50.3%), sensory disturbances (44%), motor symptoms (33.2%), and optic neuritis (26.4%) as common initial manifestations. Nineteen children had facial paralysis and 10 had epileptic seizures at first attack; 21 (11%) were initially diagnosed with acute disseminated encephalomyelitis (ADEM). Oligoclonal bands were identified in 68% of patients. Magnetic resonance imaging revealed periventricular (96%), cortical/juxtacortical (64.2%), brainstem (63%), cerebellum (51.4%), and spinal cord (67%) involvement. Visual evoked potentials (VEP) were abnormal in 52%; serum 25-hydroxyvitamin D levels were low in 68.5% of patients. The earlier-onset group had a higher rate of infection/vaccination preceding initial attack, initial diagnosis of ADEM, longer interval between first 2 attacks, and more disability accumulating in the first 3 years of the disease. Conclusion Brainstem and cerebellum are common sites of clinical and radiological involvement in pediatric-onset MS. VEP abnormalities are frequent even in patients without history of optic neuropathy. Vitamin D status does not appear to affect the course in early disease. MS beginning before 12 years of age has certain characteristics in history and course. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | W.B. Saunders Ltd | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Imaging | en_US |
dc.subject | Magnetic Resonance | en_US |
dc.subject | Multiple Sclerosis | en_US |
dc.subject | Pediatric | en_US |
dc.subject | Relapse | en_US |
dc.subject | Visual Evoked Potentials | en_US |
dc.subject | Vitamin D | en_US |
dc.title | Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database | en_US |
dc.type | article | en_US |
dc.relation.ispartof | European Journal of Paediatric Neurology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 864 | en_US |
dc.identifier.endpage | 872 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.ejpn.2017.06.004 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |