Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database
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2017Author
Yılmaz, ÜnsalAnlar, Banu
Gücüyener, Kıvılcım
Yaramış, Ahmet
Cansu, Ali
Ünalp, Ayçan
Aksoy, Ayşe
Kaçar Bayram, Ayşe
Kartal, Ayşe
Tosun, Ayşe Fahriye
Serdaroğlu, Ayşe
Konuşkan, Bahadır
Sarıoğlu, Berrak
Yüzbaşı Kıpçak, Beste
Kılıç Aydın, Betül
Taşkın Dilge, Birce
Bulut, Cahide
Yılmaz, Cahide
Yarar, Coşkun
Okuyaz, Çetin
Gençsel, Çiğdem
Yüksel, Deniz
Arslan Bengi, Elif
Gürkaş, Esra
Faruk, İncecik
Serdaroğlu, Gül
Deda, Gülhis
Gürbüz, Gürkan
Gümüş, Hakan
Acer, Hamit
Tekgül, Hasan
Çaksen, Hüseyin
Per, Hüseyin
Erol, İlknur
Çarman Kürşat, Bora
Canpolat, Mehmet
Özkan, Mehpare
Direk Çobanoğulları, Meltem
Kutluk Gültekin, Muhammed
Arslan, Mutluay
Sönmez, Fatma Müjgan
Dündar, Olgaç Nihal
Koçak, Ozan
Aydın, Ömer Faruk
Toptaş, Özge
Duman, Özgür
Hergüner, Mihriban Özlem
Bozkurt, Öznur
Arıcan, Pınar
Yılmaz Keskin, Sanem
Gökben, Sarenur
Işıkay, Şedat
Kumandaş, Sefer
Edizer, Selvinaz
Kurul Hız, Semra
Saygı, Semra
Teber Tiraş, Serap
Güngör, Serdal
Altunbaşak, Şakir
Haspolat, Şenay
Sezer, Taner
Yılmaz Sevim, Tuba
Yiş, Ulaç
Öztoprak, Ülkühan
Aydoğmuş, Ümmü
Topçu, Yasemin
Öztürk, Zeynep
Karalök, Zeynep Selen
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Yılmaz, Ü., Anlar, B., Gücüyener, K., Yaramış, A., Cansu, A., Ünalp, A. ... Karalök, Z. S. (2017). Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database. European Journal of Paediatric Neurology, 21(6), 872-864. https://dx.doi.org/10.1016/j.ejpn.2017.06.004Abstract
Objective To document the clinical and paraclinical features of pediatric multiple sclerosis (MS) in Turkey. Methods Data of MS patients with onset before age 18 years (n = 193) were collected from 27 pediatric neurology centers throughout Turkey. Earlier-onset (<12 years) and later-onset (?12 years) groups were compared. Results There were 123 (63.7%) girls and 70 (36.3%) boys aged 4–17 years, median 14 years at disease onset. Family history of MS was 6.5%. The first presentation was polysymptomatic in 55.4% of patients, with brainstem syndromes (50.3%), sensory disturbances (44%), motor symptoms (33.2%), and optic neuritis (26.4%) as common initial manifestations. Nineteen children had facial paralysis and 10 had epileptic seizures at first attack; 21 (11%) were initially diagnosed with acute disseminated encephalomyelitis (ADEM). Oligoclonal bands were identified in 68% of patients. Magnetic resonance imaging revealed periventricular (96%), cortical/juxtacortical (64.2%), brainstem (63%), cerebellum (51.4%), and spinal cord (67%) involvement. Visual evoked potentials (VEP) were abnormal in 52%; serum 25-hydroxyvitamin D levels were low in 68.5% of patients. The earlier-onset group had a higher rate of infection/vaccination preceding initial attack, initial diagnosis of ADEM, longer interval between first 2 attacks, and more disability accumulating in the first 3 years of the disease. Conclusion Brainstem and cerebellum are common sites of clinical and radiological involvement in pediatric-onset MS. VEP abnormalities are frequent even in patients without history of optic neuropathy. Vitamin D status does not appear to affect the course in early disease. MS beginning before 12 years of age has certain characteristics in history and course.
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European Journal of Paediatric NeurologyVolume
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