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dc.contributor.authorDaşdelen, Muhammed Furkan
dc.contributor.authorEr, Sezgin
dc.contributor.authorKaplan, Berkan
dc.contributor.authorÇelik, Süleyman
dc.contributor.authorBeker, Mustafa Çağlar
dc.contributor.authorOrhan, Cemal
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorMamedova, Havakhanum
dc.contributor.authorSylla, Sarah
dc.contributor.authorKomorowski, James
dc.contributor.authorOjalvo, Sara Perez
dc.date.accessioned2022-05-06T08:23:39Z
dc.date.available2022-05-06T08:23:39Z
dc.date.issued2022en_US
dc.identifier.citationDaşdelen, M. F., Er, S., Kaplan, B., Çelik, S., Beker, M. Ç., Orhan, C. ... Ojalvo, S. P. (2022). A novel theanine complex, Mg-L-Theanine improves sleep quality via regulating brain electrochemical activity. Frontiers in Nutrition, 9. https://doi.org/110.3389/fnut.2022.874254en_US
dc.identifier.issn2296-861X
dc.identifier.urihttps://doi.org/110.3389/fnut.2022.874254
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9408
dc.description.abstractL-Theanine is commonly used to improve sleep quality through inhibitory neurotransmitters. On the other hand, Mg2+, a natural NMDA antagonist and GABA agonist, has a critical role in sleep regulation. Using the caffeine-induced brain electrical activity model, here we investigated the potency of L-theanine and two novel Mg-L-theanine compounds with different magnesium concentrations on electrocorticography (ECoG) patterns, GABAergic and serotonergic receptor expressions, dopamine, serotonin, and melatonin levels. Furthermore, we evaluated the sleep latency and duration in the pentobarbital induced sleep model. We herein showed that L-theanine, particularly its various complexes with magnesium increases the expression of GABAergic, serotonergic, and glutamatergic receptors, which were associated with decreased ECoG frequency, increased amplitude, and enhanced delta wave powers. Besides increased dopamine, serotonin, and melatonin; decreased MDA and increased antioxidant enzyme levels were also observed particularly with Mg-complexes. Protein expression analyses also showed that Mg-L-theanine complexes decrease inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) levels significantly. In accordance with these results, Mg complexes improved the sleep latency and duration even after caffeine administration. As a result, our data indicate that Mg-L-theanine compounds potentiate the effect of L-theanine on sleep by boosting slow-brain waves, regulating brain electrical activity, and increasing neurotransmitter and GABA receptor levels.en_US
dc.language.isoengen_US
dc.publisherFrontiers Media S.A.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectGABA Receptorsen_US
dc.subjectL-Theanineen_US
dc.subjectMagnesiumen_US
dc.subjectNeurotransmittersen_US
dc.subjectSleepen_US
dc.titleA novel theanine complex, Mg-L-Theanine improves sleep quality via regulating brain electrochemical activityen_US
dc.typearticleen_US
dc.relation.ispartofFrontiers in Nutritionen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesien_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-2251-2093en_US
dc.authorid0000-0001-7266-9844en_US
dc.authorid0000-0003-4514-2902en_US
dc.authorid0000-0002-9476-8488en_US
dc.identifier.volume9en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3389/fnut.2022.874254en_US
dc.institutionauthorDaşdelen, Muhammed Furkan
dc.institutionauthorEr, Sezgin
dc.institutionauthorKaplan, Berkan
dc.institutionauthorÇelik, Süleyman
dc.institutionauthorBeker, Mustafa Çağlar
dc.institutionauthorMamedova, Havakhanum
dc.identifier.wosqualityQ1en_US
dc.identifier.wos000790336000001en_US
dc.identifier.scopus2-s2.0-85128691143en_US
dc.identifier.pmid35449538en_US
dc.identifier.scopusqualityQ1en_US


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