ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury
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info:eu-repo/semantics/openAccessAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/Date
2022Author
Rohlfing, Anne-KatrinKolb, Kyra
Sigle, Manuel
Ziegler, Melanie
Bild, Alexander
Münzer, Patrick
Sudmann, Jessica
Dicenta, Valerie
Harm, Tobias
Manke, Mailin-Christin
Geue, Sascha
Kremser, Marcel
Chatterjee, Madhumita
Liang, Chunguang
Eysmondt, Hendrik von
Dandekar, Thomas
Heinzmann, David
Günter, Manina
Ungern-Sternberg, Saskia von
Büttcher, Manuela
Castor, Tatsiana
Mencl, Stine
Langhauser, Friederike
Sies, Katharina
Ashour, Diyaa
Beker, Mustafa Çağlar
Lämmerhofer, Michael
Autenrieth, Stella E.
Schäffer, Tilman E.
Laufer, Stefan
Szklanna, Paulina
Maguire, Patricia
Heikenwalder, Matthias
Müller, Karin Anne Lydia
Hermann, Dirk M.
Kılıç, Ertuğrul
Stumm, Ralf
Ramos, Gustavo
Kleinschnitz, Christoph
Borst, Oliver
Langer, Harald F.
Rath, Dominik
Gawaz, Meinrad
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Rohlfing, A.-K., Kolb, K., Sigle, M., Ziegler, M., Bild, A., Münzer, P. ... Gawaz, M. (2022). ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-29341-1Abstract
Platelet activation plays a critical role in thrombosis. Inhibition of platelet activation is a cornerstone in treatment of acute organ ischemia. Platelet ACKR3 surface expression is independently associated with all-cause mortality in CAD patients. In a novel genetic mouse strain, we show that megakaryocyte/platelet-specific deletion of ACKR3 results in enhanced platelet activation and thrombosis in vitro and in vivo. Further, we performed ischemia/reperfusion experiments (transient LAD-ligation and tMCAO) in mice to assess the impact of genetic ACKR3 deficiency in platelets on tissue injury in ischemic myocardium and brain. Loss of platelet ACKR3 enhances tissue injury in ischemic myocardium and brain and aggravates tissue inflammation. Activation of platelet-ACKR3 via specific ACKR3 agonists inhibits platelet activation and thrombus formation and attenuates tissue injury in ischemic myocardium and brain. Here we demonstrate that ACKR3 is a critical regulator of platelet activation, thrombus formation and organ injury following ischemia/reperfusion.
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