Adult case series of extramedullary relapsing acute myeloid leukemia (AML) after allogeneic stem cell transplantation in whom a rapid response and a reasonably long remission could be achieved with gemtuzumab ozogamycin (GO)

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Erişim
info:eu-repo/semantics/openAccessTarih
2019Yazar
Sevindik, Ömür GökmenGemici, Aliihsan
Usta, Furkan Selim
Çakır, Aslı
Sadri, Sevil
Bekoz, Hüseyin
Sargın, Fatma Deniz
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Sevindik, Ö. G., Gemici, A., Usta, F. S., Çakır, A., Sadri, S., Bekoz, H. ... Sargın, F. D. (2019). Adult case series of extramedullary relapsing acute myeloid leukemia (AML) after allogeneic stem cell transplantation in whom a rapid response and a reasonably long remission could be achieved with gemtuzumab ozogamycin (GO). 61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH). Orlando Florida, December 7-10, 2019. https://dx.doi.org/10.1182/blood-2019-126195Özet
Gemtuzumab Ozogamycin (GO) is a drug conjugated monoclonal antibody which targets CD33 an antigen highly expressed on the surface of AML blasts. GO is approved for the treatment of both newly-diagnosed and relapsed AML. Despite growing evidence regarding its efficacy and safety among AML patients there is limited data about the use of GO in isolated extra-medullary relapsed AML. Extramedullary AML remains as an unmet clinical need regarding the poor prognosis and lack of a standard therapeutic approach. Our cases demonstrated a rapid and long lasting response with a favorable toxicity profile, in patients who were treated with GO as a single agent after an isolated extramedullary relapsing disease.
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61st Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)Cilt
134Sayı
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