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dc.contributor.authorDandin, Esra
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorÜnal, İsmail
dc.contributor.authorAteş Kalkan, Perihan Seda
dc.contributor.authorCansız, Derya
dc.contributor.authorBeler, Merih
dc.contributor.authorAk, Esin
dc.contributor.authorAlturfan, A. Ata
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned2022-03-10T07:58:38Z
dc.date.available2022-03-10T07:58:38Z
dc.date.issued2022en_US
dc.identifier.citationDandin, E., Üstündağ, Ü. V., Ünal, İ., Ateş Kalkan, P. S., Cansız, D. ve Beler, M. (2022). Stevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulation. Obesity Research & Clinical Practice, 16(1), 23-29. https://doi.org/10.1016/j.orcp.2022.01.002en_US
dc.identifier.issn1871-403X
dc.identifier.issn1878-0318
dc.identifier.urihttps://doi.org/10.1016/j.orcp.2022.01.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9110
dc.description.abstractObesity is an independent risk factor for type 2 diabetes and epigenetic regulatory mechanisms affect obesityrelated mechanisms. Due to weight gain concern in society, artificial sweeteners with no nutritional value have been increasingly consumed. Stevia is a sweet natural glycoside and a calorie-free sweetner extracted from the leaves of Stevia rebaudiana Bertoni and used as a substitute for artificial sweetners. This study evaluates the effects of stevioside on glucose tolerance, epigenetic and metabolic regulators of insulin resistance, oxidant-antioxidant status and tissue histology in a diet-induced obese (DIO) zebrafish model. After 15 days of overfeeding body weight, and fasting blood glucose, lipid peroxidation and nitric oxide levels and the expressions of fbf21, lepa, ll21, tnf alpha were elevated, where as there was impaired glucose tolerance and lower superoxide dismutase and glutathione S-transferase activities, dnmt3a expression which is an epigenetic tool of insulin resistance. Beneficial effects of stevioside were observed on glucose tolerance, oxidative stress and inflammatory mediators linking obesity to insulin resistance and its epigenetic regulation, in DIO model.en_US
dc.description.sponsorshipMarmara Universityen_US
dc.language.isoengen_US
dc.publisherElsevier Ltden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectDiet-Induced Obesityen_US
dc.subjectGlucose Intoleranceen_US
dc.subjectOxidative Stressen_US
dc.subjectSteviosideen_US
dc.subjectZebrafishen_US
dc.titleStevioside ameliorates hyperglycemia and glucose intolerance, in a diet-induced obese zebrafish model, through epigenetic, oxidative stress and inflammatory regulationen_US
dc.typearticleen_US
dc.relation.ispartofObesity Research & Clinical Practiceen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0003-0804-1475en_US
dc.identifier.volume16en_US
dc.identifier.issue1en_US
dc.identifier.startpage23en_US
dc.identifier.endpage29en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.orcp.2022.01.002en_US
dc.institutionauthorÜstündağ, Ünsal Veli
dc.institutionauthorCansız, Derya
dc.identifier.wosqualityQ4en_US
dc.identifier.wos000755773400004en_US
dc.identifier.scopus2-s2.0-85122614318en_US
dc.identifier.pmid35031270en_US
dc.identifier.scopusqualityQ2en_US


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