dc.contributor.author | Bülbül, Muhammet Volkan | |
dc.contributor.author | Özbek, Hanefi | |
dc.contributor.author | Bahadır Acıkara, Özlem | |
dc.contributor.author | Özbilgin, Serkan | |
dc.contributor.author | Ergene Öz, Burçin | |
dc.contributor.author | Kurtul, Ekin | |
dc.contributor.author | Keskin, İlknur | |
dc.date.accessioned | 2022-03-02T06:04:17Z | |
dc.date.available | 2022-03-02T06:04:17Z | |
dc.date.issued | 2018 | en_US |
dc.identifier.citation | Bülbül, M. V., Özbek, H., Bahadır Acıkara, Ö., Özbilgin, S., Ergene Öz, B., Kurtul, E. ... Keskin, İ. (2018). Antiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells. Journal of Experimental and Clinical Medicine (Turkey), 35(4), 101-109. https://doi.org/10.5835/jecm.omu.35.04.003 | en_US |
dc.identifier.issn | 1309-4483 | |
dc.identifier.uri | https://doi.org/10.5835/jecm.omu.35.04.003 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9051 | |
dc.description.abstract | In this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis galegifolia Boiss. and Onobrychis tournefortii (Willd.) Desv. species to HCT-116 cells were investigated. With cytotoxicity analysis that with these species inhibitor concentrations (IC50) which resulted in a 50% reduction in the proliferation of HCT-116 cells were identified. In continuation of the study; the antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells were evaluated by Caspase 3, Annexin V / PI Apoptosis / Necrosis analysis, Apopxin Green and 7-AAD Apoptosis / Necrosis analysis. The antiproliferative, apoptotic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Ondokuz Mayıs University | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Flow Cytometry | en_US |
dc.subject | HCT-116 | en_US |
dc.subject | HEK-293 | en_US |
dc.subject | Necrosis | en_US |
dc.title | Antiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Experimental and Clinical Medicine (Turkey) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-8084-7855 | en_US |
dc.authorid | 0000-0002-7059-1884 | en_US |
dc.identifier.volume | 35 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 101 | en_US |
dc.identifier.endpage | 109 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.5835/jecm.omu.35.04.003 | en_US |
dc.institutionauthor | Bülbül, Muhammet Volkan | |
dc.institutionauthor | Özbek, Hanefi | |
dc.institutionauthor | Keskin, İlknur | |
dc.identifier.scopus | 2-s2.0-85105280785 | en_US |
dc.identifier.scopusquality | Q4 | en_US |