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dc.contributor.authorBakavicius, A.
dc.contributor.authorMarra, G.
dc.contributor.authorMacek, P.
dc.contributor.authorRobertson, C.
dc.contributor.authorAbreu, A. L.
dc.contributor.authorGeorge, A. K.
dc.contributor.authorMalavaud, B.
dc.contributor.authorColoby, P.
dc.contributor.authorRischmann, P.
dc.contributor.authorMoschini, M.
dc.contributor.authorRastinehad, A. R.
dc.contributor.authorSidana, A.
dc.contributor.authorStabile, A.
dc.contributor.authorTourinho-Barbosa, R.
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authorAhmed, H.
dc.contributor.authorPolascik, T.
dc.contributor.authorCathelineau, X.
dc.contributor.authorSanchez-Salas, R.
dc.identifier.citationBakavicius, A., Marra, G., Macek, P., Robertson, C., Abreu, A. L., George, A. K. ... Sanchez-Salas, R. (2022). Available evidence on HIFU for focal treatment of prostate cancer: A systematic review. International Braz j Urol : Official journal of the Brazilian Society of Urology, 48(2), 263-274.
dc.description.abstractPURPOSE: Prostate cancer (PCa) is the second most common oncologic disease among men. Radical treatment with curative intent provides good oncological results for PCa survivors, although definitive therapy is associated with significant number of serious side-effects. In modern-era of medicine tissue-sparing techniques, such as focal HIFU, have been proposed for PCa patients in order to provide cancer control equivalent to the standard-of-care procedures while reducing morbidities and complications. The aim of this systematic review was to summarise the available evidence about focal HIFU therapy as a primary treatment for localized PCa. MATERIAL AND METHODS: We conducted a comprehensive literature review of focal HIFU therapy in the MEDLINE database (PROSPERO: CRD42021235581). Articles published in the English language between 2010 and 2020 with more than 50 patients were included. RESULTS: Clinically significant in-field recurrence and out-of-field progression were detected to 22% and 29% PCa patients, respectively. Higher ISUP grade group, more positive cores at biopsy and bilateral disease were identified as the main risk factors for disease recurrence. The most common strategy for recurrence management was definitive therapy. Six months after focal HIFU therapy 98% of patients were totally continent and 80% of patients retained sufficient erections for sexual intercourse. The majority of complications presented in the early postoperative period and were classified as low-grade. CONCLUSIONS: This review highlights that focal HIFU therapy appears to be a safe procedure, while short-term cancer control rate is encouraging. Though, second-line treatment or active surveillance seems to be necessary in a significant number of patients.en_US
dc.publisherNLM (Medline)en_US
dc.subjectHigh-Intensity Focused Ultrasound Ablationen_US
dc.subjectProstate Canceren_US
dc.subjectFamilial [Supplementary Concept]en_US
dc.subjectComplications [Subheading]en_US
dc.titleAvailable evidence on HIFU for focal treatment of prostate cancer: A systematic reviewen_US
dc.relation.ispartofInternational Braz j Urol : Official journal of the Brazilian Society of Urologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalıen_US
dc.institutionauthorde la Rosette, Jean J. M. C. H.

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