Antisperm antibody testing: A comprehensive review of its role in the management of immunological male infertility and results of a global survey of clinical practices
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info:eu-repo/semantics/openAccessAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/Date
2022Author
Gupta, SajalSharma, Rakesh
Agarwal, Ashok
Boitrelle, Florence
Finelli, Renata
Farkouh, Ala’a
Saleh, Ramadan
Abdel Meguid, Taha Abo Almagd
Gül, Murat
Zilaitiene, Birute
Ko, Edmund
Rambhatla, Amarnath
Zini, Armand
Leisegang, Kristian
Kuroda, Shinnosuke
Henkel, Ralf
Cannarella, Rossella
Palani, Ayad
Cho, Chak Lam
Ho, Christopher C.K.
Zylbersztejn, Daniel Suslik
Pescatori, Edoardo
Chung, Eric
Dimitriadis, Fotios
Pinggera, Germar Michael
Busetto, Gian Maria
Balercia, Giancarlo
Salvio, Gianmaria
Colpi, Giovanni M.
Çeker, Gökhan
Taniguchi, Hisanori
Kandil, Hussein
Park, Hyun Jun
Rosas, Israel Maldonado
Rosette, Jean de la
Greco Cardoso, Joao Paulo
Ramsay, Jonathan
Alvarez, Juan
Corral Molina, Juan Manuel
Khalafalla, Kareim
Bowa, Kasonde
Tremellen, Kelton
Evgeni, Evangelini
Rocco, Lucia
Rodriguez Peña, Marcelo Gabriel
Sabbaghian, Marjan
Martinez, Marlon
Arafa, Mohamed
Al-Marhoon, Mohamed S.
Tadros, Nicholas
Garrido, Nicolas
Rajmil, Osvaldo
Sengupta, Pallav
Vogiatzi, Paraskevi
Kavoussi, Parviz
Birowo, Ponco
Kosgi, Raghavender
Bani Hani, Saleem
Micic, Sava
Parekattil, Sijo
Jindal, Sunil
Le, Tan V.
Mostafa, Taymour
Toprak, Tuncay
Morimoto, Yoshiharu
Malhotra, Vineet
Aghamajidi, Azin
Durairajanayagam, Damayanthi
Shah, Rupin
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Gupta, S., Sharma, R., Agarwal, A., Boitrelle, F., Finelli, R., Farkouh, A. ... Shah, R. (2022). Antisperm antibody testing: A comprehensive review of its role in the management of immunological male infertility and results of a global survey of clinical practices. World Journal of Men's Health, 40. https://doi.org/10.5534/wjmh.210164Abstract
Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are due to an abnormal exposure of mature germ cells to the immune system. ASA testing (with mixed anti-globulin reaction, and immunobead binding test) was described in the WHO manual 5th edition and is most recently listed among the extended semen tests in the WHO manual 6th edition. The relationship between ASA and infertility is somewhat complex. The presence of sperm agglutination, while insufficient to diagnose immunological infertility, may indicate the presence of ASA. However, ASA can also be present in the absence of any sperm agglutination. The andrological management of ASA depends on the etiology and individual practices of clinicians. In this article, we provide a comprehensive review of the causes of ASA production, its role in immunological male infertility, clinical indications of ASA testing, and the available therapeutic options. We also provide the details of laboratory procedures for assessment of ASA together with important measures for quality control. Additionally, laboratory and clinical scenarios are presented to guide the reader in the management of ASA and immunological male infertility. Furthermore, we report the results of a recent worldwide survey, conducted to gather information about clinical practices in the management of immunological male infertility.