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dc.contributor.authorÇelik, Çağrı
dc.contributor.authorBayrak, Bertan Boran
dc.contributor.authorHacıhasanoğlu Çakmak, Neziha
dc.contributor.authorYanardağ, Refiye
dc.date.accessioned2022-01-10T07:13:47Z
dc.date.available2022-01-10T07:13:47Z
dc.date.issued2022en_US
dc.identifier.citationÇelik, Ç., Bayrak, B. B., Hacıhasanoğlu Çakmak, N. ve Yanardağ, R. (2022). Protective effect of edaravone on rat testis after valproic acid treatment. Journal of Research in Pharmacy, 26(1), 52-62. https://doi.org/10.29228/jrp.103en_US
dc.identifier.issn2630-6344
dc.identifier.urihttps://doi.org/10.29228/jrp.103
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8789
dc.description.abstractValproic acid n-dipropyl-acetic acid, VPA) is a medication used as anticonvulsant in the treatment of bipolar disorder, and for migraine prophylaxis. Long-term use of VPA is known to trigger reproductive impairment, which is mediated by elevation of testicular oxidative stress. Edaravone is used in the treatment of cerebrovascular diseases. It can diffuse into many disease-affected organs, thus shows protective effects in numerous tissues including the heart, lung, and testis. The main goal of the present study was to determine the possible protective role of edaravone against VPA-induced oxidative testicular injury. Male Sprague Dawley rats were assigned into four groups. Control rats; rats given only edaravone (30 mg/kg/day); rats given only VPA (500 mg/kg/day); rats given VPA+edaravone for seven days. Edaravone and VPA were applied intraperitoneally. After eight days, testicular tissues were taken from rats. There was a statistically significant increase in the levels of reduced glutathione, lipid peroxidation, reactive oxygen species, total oxidant status, oxidative stress index, and DNA contents as well as catalase, superoxide dismutase, glutathione-related enzymes, gamma-glutamyl transferase, acid and alkaline phosphatases, lactate dehydrogenase, myeloperoxidase and sorbitol dehydrogenase activities in VPA group. More so, advanced oxidized protein products, protein carbonyl, and nitric oxide levels were also significantly increased in VPA group. Activities of glucose-6-phosphate dehydrogenase and sodium/potassium ATPase and total antioxidant status levels remarkably decreased in VPA given group. Treatment with edaravone to VPA group significantly reverted these alterations. These findings demonstrate that administration of edaravone has a beneficial effect against testicular injury in VPA-induced oxidative stress.en_US
dc.description.sponsorshipIstanbul University-Cerrahpasa Scientific Research Projects Uniten_US
dc.language.isoengen_US
dc.publisherMarmara Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEdaravoneen_US
dc.subjectTestis Injuryen_US
dc.subjectValproic Aciden_US
dc.subjectOxidative Stress Parametersen_US
dc.subjectAntioxidant Enzymesen_US
dc.titleProtective effect of edaravone on rat testis after valproic acid treatmenten_US
dc.typearticleen_US
dc.relation.ispartofJournal of Research in Pharmacyen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Ana Bilim Dalıen_US
dc.authorid0000-0002-6183-5015en_US
dc.identifier.volume26en_US
dc.identifier.issue1en_US
dc.identifier.startpage52en_US
dc.identifier.endpage62en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.29228/jrp.103en_US
dc.identifier.scopusqualityQ3en_US


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